Co-expression Network Analysis

Interactive visualization of gene co-expression networks, expression and funtional enrichment analysis.

📊 Global Network of OS493_024250-T1
Network Legend
Yellow: Query proteins
Green: Interaction proteins
Pink line: Own interaction + positive co-expression
Blue line: Own interaction + negative co-expression
Node size reflects how many connections the gene has (hubs are drawn larger). Hover any node to see the annotation of the gene it stands for (PANTHER / InterPro / GO description, or NR when the others are absent) and a link to its gene page.
📋 View Detailed Network Information
Co-expressed Genes of OS493_024250-T1
Gene ID Description PCC Relationship
OS493_024250-T1NEPHRIN1positive
OS493_011751-T1CYSTEINE-RICH SECRETORY PROTEIN-RELATED0.85positive
OS493_035193-T1--0.85positive
OS493_020693-T1XK-RELATED PROTEIN0.85positive
OS493_037131-T1CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN0.84positive
OS493_037132-T1CONTACTIN 50.84positive
OS493_009517-T1LEUCOKININ RECEPTOR-RELATED0.84positive
OS493_022741-T1MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED0.83positive
OS493_009518-T1LEUCOKININ RECEPTOR-RELATED0.83positive
OS493_006947-T1METABOTROPIC GLUTAMATE RECEPTOR0.83positive
OS493_010479-T1--0.82positive
OS493_015745-T1--0.82positive
OS493_027828-T1THROMBOSPONDIN-TYPE LAMININ G DOMAIN AND EAR REPEAT-CONTAINING0.82positive
OS493_020521-T1SPROUTY0.82positive
OS493_011677-T1--0.81positive
OS493_030377-T1--0.77positive
OS493_027135-T1--0.77positive
OS493_038728-T1--0.75positive
OS493_017743-T1LEUCOKININ RECEPTOR-RELATED0.75positive
OS493_005195-T1--0.73positive
Further Analysis for Network Members
Next Step: Dynamic Expression View

What this does. Everything above treats every gene the same way. Dynamic Expression View redraws this same network but colours each node by how much that gene changes between two conditions, so you can see which part of the network responds. It needs one input the network itself does not carry: a per-gene expression ratio.

Where the ratio comes from. CnidoSite holds an RNA-seq expression matrix for this species, so the ratio can be built here rather than elsewhere: pick the samples for each side of your comparison and every gene gets log2((mean of group A + 1) / (mean of group B + 1)). This network has 64 gene pairs and one run of Dynamic Expression View draws at most 10, so the button below carries the 10 with the strongest |PCC|.

Gene pairs carried over (10)
Opens the ratio builder with these pairs already loaded. It computes the ratios, then hands both the pairs and the ratios to the network view in one step.
Or take the pairs by hand
Click to select all, then paste into step 2 of Dynamic Expression View as GeneA GeneB, one pair per line. Its step 3 still needs the expression ratios.
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