Co-expression Network Analysis

Interactive visualization of gene co-expression networks, expression and funtional enrichment analysis.

📊 Global Network of XP_031574449.1
Network Legend
Yellow: Query proteins
Green: Interaction proteins
Pink line: Own interaction + positive co-expression
Blue line: Own interaction + negative co-expression
Node size reflects how many connections the gene has (hubs are drawn larger). Hover any node to see the annotation of the gene it stands for (PANTHER / InterPro / GO description, or NR when the others are absent) and a link to its gene page.
📋 View Detailed Network Information
Co-expressed Genes of XP_031574449.1
Gene ID Description PCC Relationship
XP_031574449.1PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL HOMOLOG1positive
XP_031573152.1NG370.95positive
XP_031548861.1ENDOGLIN/TGF-BETA RECEPTOR TYPE III0.95positive
XP_031553555.1PITUITARY HOMEOBOX HOMOLOG PTX10.94positive
XP_031552698.1CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE0.94positive
XP_031553072.1PHOSPHOTYROSINE INTERACTION DOMAIN-CONTAINING FAMILY MEMBER0.94positive
XP_031552696.1NETRIN/LAMININ-RELATED0.93positive
XP_031564321.1INTEGRAL MEMBRANE PROTEIN GPR1770.93positive
XP_031565007.1FRIZZLED0.93positive
XP_031564940.1NUCLEOBINDIN0.92positive
XP_031555275.1TYROSINE-PROTEIN KINASE RECEPTOR0.92positive
XP_031558033.1LD33804P0.91positive
XP_031572917.1--0.91positive
XP_031548904.1FCH AND DOUBLE SH3 DOMAINS PROTEIN0.91positive
XP_031574412.1HELICASE SRCAP-RELATED0.91positive
XP_031568268.1--0.90positive
XP_031572892.1ADHESION G-PROTEIN COUPLED RECEPTOR0.87positive
XP_031549703.1MULTICOPPER OXIDASE-RELATED0.87positive
XP_031565129.1OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR0.84positive
Further Analysis for Network Members
Next Step: Dynamic Expression View

What this does. Everything above treats every gene the same way. Dynamic Expression View redraws this same network but colours each node by how much that gene changes between two conditions, so you can see which part of the network responds. It needs one input the network itself does not carry: a per-gene expression ratio.

Where the ratio comes from. CnidoSite holds an RNA-seq expression matrix for this species, so the ratio can be built here rather than elsewhere: pick the samples for each side of your comparison and every gene gets log2((mean of group A + 1) / (mean of group B + 1)). This network has 51 gene pairs and one run of Dynamic Expression View draws at most 10, so the button below carries the 10 with the strongest |PCC|.

Gene pairs carried over (10)
Opens the ratio builder with these pairs already loaded. It computes the ratios, then hands both the pairs and the ratios to the network view in one step.
Or take the pairs by hand
Click to select all, then paste into step 2 of Dynamic Expression View as GeneA GeneB, one pair per line. Its step 3 still needs the expression ratios.
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