Co-expression Network Analysis

Interactive visualization of gene co-expression networks, expression and funtional enrichment analysis.

📊 Global Network of XP_074627770.1
Network Legend
Yellow: Query proteins
Green: Interaction proteins
Pink line: Own interaction + positive co-expression
Blue line: Own interaction + negative co-expression
Node size reflects how many connections the gene has (hubs are drawn larger). Hover any node to see the annotation of the gene it stands for (PANTHER / InterPro / GO description, or NR when the others are absent) and a link to its gene page.
📋 View Detailed Network Information
Co-expressed Genes of XP_074627770.1
Gene ID Description PCC Relationship
XP_074627770.1RIBONUCLEASE KAPPA1positive
XP_074612598.1MUCOLIPIN0.84positive
XP_074621898.1SI:DKEY-19B23.12-RELATED0.83positive
XP_074611999.1GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD450.83positive
XP_074615726.1BCL-2 RELATED0.82positive
XP_074617248.1ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD0.81positive
XP_074611310.1ANCIENT UBIQUITOUS PROTEIN0.81positive
XP_074631021.1SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B0.80positive
XP_074639873.1MULTICOPPER OXIDASE-RELATED0.80positive
XP_074607333.1--0.80positive
XP_074632542.1LD44762P0.79positive
XP_074620974.1GLYCOSYL TRANSFERASE0.79positive
XP_074633922.1CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE0.79positive
XP_074634169.1BETA-AMYLOID BINDING PROTEIN-RELATED0.78positive
XP_074610942.1GEO07743P10.77positive
XP_074613676.14.1 G PROTEIN0.76positive
XP_074621216.1NACHT DOMAIN-CONTAINING PROTEIN0.75positive
Further Analysis for Network Members
Next Step: Dynamic Expression View

What this does. Everything above treats every gene the same way. Dynamic Expression View redraws this same network but colours each node by how much that gene changes between two conditions, so you can see which part of the network responds. It needs one input the network itself does not carry: a per-gene expression ratio.

Where the ratio comes from. CnidoSite holds an RNA-seq expression matrix for this species, so the ratio can be built here rather than elsewhere: pick the samples for each side of your comparison and every gene gets log2((mean of group A + 1) / (mean of group B + 1)). This network has 44 gene pairs and one run of Dynamic Expression View draws at most 10, so the button below carries the 10 with the strongest |PCC|.

Gene pairs carried over (10)
Opens the ratio builder with these pairs already loaded. It computes the ratios, then hands both the pairs and the ratios to the network view in one step.
Or take the pairs by hand
Click to select all, then paste into step 2 of Dynamic Expression View as GeneA GeneB, one pair per line. Its step 3 still needs the expression ratios.
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