Co-expression Network Analysis

Interactive visualization of gene co-expression networks, expression and funtional enrichment analysis.

📊 Global Network of evm.model.Ap12.1126
Network Legend
Yellow: Query proteins
Green: Interaction proteins
Pink line: Own interaction + positive co-expression
Blue line: Own interaction + negative co-expression
Node size reflects how many connections the gene has (hubs are drawn larger). Hover any node to see the annotation of the gene it stands for (PANTHER / InterPro / GO description, or NR when the others are absent) and a link to its gene page.
📋 View Detailed Network Information
Co-expressed Genes of evm.model.Ap12.1126
Gene ID Description PCC Relationship
evm.model.Ap12.1126HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR1positive
evm.model.Ap9.850L1 TRANSPOSABLE ELEMENT-RELATED0.96positive
Thr_2486--0.95positive
Thr_2863--0.95positive
Thr_3107--0.95positive
Thr_4008--0.95positive
Thr_885--0.95positive
evm.model.Ap1.1131--0.95positive
evm.model.Ap1.1242--0.95positive
evm.model.Ap1.1910BTB DOMAIN-CONTAINING PROTEIN0.95positive
evm.model.Ap1.1970--0.95positive
evm.model.Ap1.2403BTB/POZ DOMAIN-CONTAINING0.95positive
evm.model.Ap1.2431BTB/POZ DOMAIN-CONTAINING0.95positive
evm.model.Ap1.2554--0.95positive
evm.model.Ap1.2933GLYCOPROTEIN HORMONE RECEPTOR0.95positive
evm.model.Ap1.3095APPLE DOMAIN-CONTAINING PROTEIN0.95positive
evm.model.Ap1.3197HISTONE H40.95positive
evm.model.Ap1.3481RAPSYN-RELATED0.95positive
evm.model.Ap10.1080OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR0.95positive
evm.model.Ap11.439OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR0.95positive
evm.model.Ap11.458RETROTRANSPOSON0.95positive
evm.model.Ap11.494BTB/POZ DOMAIN-CONTAINING0.95positive
evm.model.Ap11.948APPLE DOMAIN-CONTAINING PROTEIN0.95positive
evm.model.Ap12.1561NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR0.95positive
evm.model.Ap12.2286--0.95positive
evm.model.Ap13.149OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR0.95positive
evm.model.Ap14.1695T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN0.95positive
evm.model.Ap14.1792NUCLEOREDOXIN-LIKE PROTEIN 20.95positive
evm.model.Ap2.1988PHOSPHATIDYLSERINE DECARBOXYLASE0.95positive
evm.model.Ap2.3376--0.95positive
evm.model.Ap3.1922OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR0.95positive
evm.model.Ap3.2013DNA HELICASE RECQ FAMILY MEMBER0.95positive
evm.model.Ap4.295OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR0.95positive
evm.model.Ap4.3152THAP DOMAIN PROTEIN0.95positive
evm.model.Ap4.3264--0.95positive
evm.model.Ap4.346--0.95positive
evm.model.Ap4.357--0.95positive
evm.model.Ap4.3580RETROTRANSPOSON0.95positive
evm.model.Ap4.4287--0.95positive
evm.model.Ap4.4393AP ENDONUCLEASE0.95positive
evm.model.Ap4.5526--0.95positive
evm.model.Ap4.6418G PROTEIN-COUPLED RECEPTOR0.95positive
evm.model.Ap4.6552REVERSE TRANSCRIPTASE0.95positive
evm.model.Ap5.2404OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR0.95positive
evm.model.Ap5.2856NECTIN-RELATED0.95positive
evm.model.Ap6.2897BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST0.95positive
evm.model.Ap6.2899BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST0.95positive
evm.model.Ap6.401--0.95positive
evm.model.Ap6.684ZINC FINGER PROTEIN0.95positive
evm.model.Ap7.1183--0.95positive
evm.model.Ap7.1227EARLY GAMETOCYTE ENRICHED PHOSPHOPROTEIN EGXP0.95positive
evm.model.Ap7.1708RETROTRANSPOSON0.95positive
evm.model.Ap7.2676--0.95positive
evm.model.Ap8.2156C2H2-TYPE DOMAIN-CONTAINING PROTEIN0.95positive
evm.model.Ap8.476F-BOX DOMAIN CONTAINING PROTEIN, EXPRESSED0.95positive
evm.model.Ap8.953--0.95positive
evm.model.Ap9.1134SYNDECAN0.95positive
evm.model.Ap9.2312--0.95positive
evm.model.Ap8.2255KRUEPPEL-LIKE TRANSCRIPTION FACTOR0.95positive
evm.model.Ap4.3819--0.93positive
evm.model.Ap8.1831--0.88positive
evm.model.Ap4.5236RETROTRANSPOSON0.83positive
evm.model.Ap12.348REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED0.76positive
Further Analysis for Network Members
Next Step: Dynamic Expression View

What this does. Everything above treats every gene the same way. Dynamic Expression View redraws this same network but colours each node by how much that gene changes between two conditions, so you can see which part of the network responds. It needs one input the network itself does not carry: a per-gene expression ratio.

Where the ratio comes from. CnidoSite holds an RNA-seq expression matrix for this species, so the ratio can be built here rather than elsewhere: pick the samples for each side of your comparison and every gene gets log2((mean of group A + 1) / (mean of group B + 1)). This network has 1888 gene pairs and one run of Dynamic Expression View draws at most 10, so the button below carries the 10 with the strongest |PCC|.

Gene pairs carried over (10)
Opens the ratio builder with these pairs already loaded. It computes the ratios, then hands both the pairs and the ratios to the network view in one step.
Or take the pairs by hand
Click to select all, then paste into step 2 of Dynamic Expression View as GeneA GeneB, one pair per line. Its step 3 still needs the expression ratios.
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