Co-expression Network Analysis

Interactive visualization of gene co-expression networks, expression and funtional enrichment analysis.

📊 Global Network of evm.model.Ap2.3408
Network Legend
Yellow: Query proteins
Green: Interaction proteins
Pink line: Own interaction + positive co-expression
Blue line: Own interaction + negative co-expression
Node size reflects how many connections the gene has (hubs are drawn larger). Hover any node to see the annotation of the gene it stands for (PANTHER / InterPro / GO description, or NR when the others are absent) and a link to its gene page.
📋 View Detailed Network Information
Co-expressed Genes of evm.model.Ap2.3408
Gene ID Description PCC Relationship
evm.model.Ap2.3408--1positive
Asp_4380--0.95positive
Thr_2900--0.95positive
Thr_4157--0.95positive
Thr_4606--0.95positive
Thr_4635--0.95positive
evm.model.Ap1.867--0.95positive
evm.model.Ap10.1471NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR0.95positive
evm.model.Ap10.677OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR0.95positive
evm.model.Ap12.23OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR0.95positive
evm.model.Ap12.757OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR0.95positive
evm.model.Ap13.375BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14430)-RELATED0.95positive
evm.model.Ap14.2029OPSIN0.95positive
evm.model.Ap14.319--0.95positive
evm.model.Ap2.922BONUS, ISOFORM C-RELATED0.95positive
evm.model.Ap4.2324--0.95positive
evm.model.Ap4.28--0.95positive
evm.model.Ap4.4312--0.95positive
evm.model.Ap7.1286REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED0.95positive
evm.model.Ap8.1183--0.95positive
evm.model.Ap8.1560--0.95positive
evm.model.Ap8.2627LEUCOKININ RECEPTOR-RELATED0.95positive
evm.model.Ap8.814--0.95positive
evm.model.Ap3.1761P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE0.94positive
evm.model.Ap13.1644PEPTIDASE0.94positive
evm.model.Ap4.6887OPSIN0.93positive
evm.model.Ap2.527PROTEIN CBG237640.93positive
evm.model.Ap4.772--0.87positive
Thr_1992--0.82positive
Thr_3214--0.81positive
evm.model.Ap13.639REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN0.81positive
evm.model.Ap10.1068OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR0.81positive
Ala_2936--0.80positive
evm.model.Ap11.1079--0.79positive
evm.model.Ap5.1579NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR0.78positive
evm.model.Ap5.2477--0.73positive
evm.model.Ap6.1017PEPTIDASE0.71positive
Further Analysis for Network Members
Next Step: Dynamic Expression View

What this does. Everything above treats every gene the same way. Dynamic Expression View redraws this same network but colours each node by how much that gene changes between two conditions, so you can see which part of the network responds. It needs one input the network itself does not carry: a per-gene expression ratio.

Where the ratio comes from. CnidoSite holds an RNA-seq expression matrix for this species, so the ratio can be built here rather than elsewhere: pick the samples for each side of your comparison and every gene gets log2((mean of group A + 1) / (mean of group B + 1)). This network has 502 gene pairs and one run of Dynamic Expression View draws at most 10, so the button below carries the 10 with the strongest |PCC|.

Gene pairs carried over (10)
Opens the ratio builder with these pairs already loaded. It computes the ratios, then hands both the pairs and the ratios to the network view in one step.
Or take the pairs by hand
Click to select all, then paste into step 2 of Dynamic Expression View as GeneA GeneB, one pair per line. Its step 3 still needs the expression ratios.
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