Co-expression Network Analysis

Interactive visualization of gene co-expression networks, expression and funtional enrichment analysis.

📊 Global Network of g16940.t1
Network Legend
Yellow: Query proteins
Green: Interaction proteins
Pink line: Own interaction + positive co-expression
Blue line: Own interaction + negative co-expression
Node size reflects how many connections the gene has (hubs are drawn larger). Hover any node to see the annotation of the gene it stands for (PANTHER / InterPro / GO description, or NR when the others are absent) and a link to its gene page.
📋 View Detailed Network Information
Co-expressed Genes of g16940.t1
Gene ID Description PCC Relationship
g16940.t1--1positive
g8629.t1DNA HELICASE RECQ FAMILY MEMBER0.91positive
g14767.t1--0.90positive
g33467.t1--0.90positive
g24175.t1TRIHELIX TRANSCRIPTION FACTOR ASIL20.89positive
g29766.t1KELCH PROTEIN0.87positive
g6885.t1TNF RECEPTOR ASSOCIATED FACTOR0.86positive
g6600.t1--0.86positive
g36101.t1PHD-TYPE DOMAIN-CONTAINING PROTEIN0.85positive
g20428.t1--0.84positive
g29182.t1--0.83positive
g10807.t1F5/8 TYPE C DOMAIN-CONTAINING PROTEIN0.82positive
g23221.t1--0.81positive
g36548.t1PROTEIN CBG266940.77positive
g27237.t1HELICASE WITH DEATH DOMAIN-RELATED0.76positive
g18400.t1ACYL-COENZYME A THIOESTERASE-RELATED0.75positive
g12965.t1LOQUACIOUS, ISOFORM B0.74positive
g18991.t1--0.73positive
g35775.t1YNEIN REGULATORY COMPLEX SUBUNIT 50.72positive
g36171.t1--0.72positive
Further Analysis for Network Members
Next Step: Dynamic Expression View

What this does. Everything above treats every gene the same way. Dynamic Expression View redraws this same network but colours each node by how much that gene changes between two conditions, so you can see which part of the network responds. It needs one input the network itself does not carry: a per-gene expression ratio.

Where the ratio comes from. CnidoSite holds an RNA-seq expression matrix for this species, so the ratio can be built here rather than elsewhere: pick the samples for each side of your comparison and every gene gets log2((mean of group A + 1) / (mean of group B + 1)). This network has 139 gene pairs and one run of Dynamic Expression View draws at most 10, so the button below carries the 10 with the strongest |PCC|.

Gene pairs carried over (10)
Opens the ratio builder with these pairs already loaded. It computes the ratios, then hands both the pairs and the ratios to the network view in one step.
Or take the pairs by hand
Click to select all, then paste into step 2 of Dynamic Expression View as GeneA GeneB, one pair per line. Its step 3 still needs the expression ratios.
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