Co-expression Network Analysis

Interactive visualization of gene co-expression networks, expression and funtional enrichment analysis.

📊 Global Network of g21458.t1
Network Legend
Yellow: Query proteins
Green: Interaction proteins
Pink line: Own interaction + positive co-expression
Blue line: Own interaction + negative co-expression
Node size reflects how many connections the gene has (hubs are drawn larger). Hover any node to see the annotation of the gene it stands for (PANTHER / InterPro / GO description, or NR when the others are absent) and a link to its gene page.
📋 View Detailed Network Information
Co-expressed Genes of g21458.t1
Gene ID Description PCC Relationship
g21458.t1SEC101positive
g34967.t1GTP-BINDING PROTEIN-RELATED0.93positive
g4456.t1ALPHA-MANNOSIDE BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE0.93positive
g2791.t1SH2-SH3 ADAPTOR PROTEIN-RELATED0.92positive
g3269.t1DEHYDROGENASE RELATED0.91positive
g341.t1NOTCH LIGAND FAMILY MEMBER0.91positive
g11027.t1ENOLASE0.91positive
g29924.t1--0.90positive
g17331.t1--0.90positive
g11953.t1C2H2-TYPE DOMAIN-CONTAINING PROTEIN0.90positive
g1039.t1SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA0.90positive
g27964.t1SECRETED MODULAR CALCIUM-BINDING PROTEIN0.89positive
g28293.t1LON PROTEASE0.89positive
g7234.t1UNCHARACTERIZED0.88positive
g29667.t1FRUCTOSAMINE 3 KINASE-RELATED PROTEIN0.80positive
Further Analysis for Network Members
Next Step: Dynamic Expression View

What this does. Everything above treats every gene the same way. Dynamic Expression View redraws this same network but colours each node by how much that gene changes between two conditions, so you can see which part of the network responds. It needs one input the network itself does not carry: a per-gene expression ratio.

Where the ratio comes from. CnidoSite holds an RNA-seq expression matrix for this species, so the ratio can be built here rather than elsewhere: pick the samples for each side of your comparison and every gene gets log2((mean of group A + 1) / (mean of group B + 1)). This network has 52 gene pairs and one run of Dynamic Expression View draws at most 10, so the button below carries the 10 with the strongest |PCC|.

Gene pairs carried over (10)
Opens the ratio builder with these pairs already loaded. It computes the ratios, then hands both the pairs and the ratios to the network view in one step.
Or take the pairs by hand
Click to select all, then paste into step 2 of Dynamic Expression View as GeneA GeneB, one pair per line. Its step 3 still needs the expression ratios.
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