Co-expression Network Analysis

Interactive visualization of gene co-expression networks, expression and funtional enrichment analysis.

📊 Global Network of g2220.t1
Network Legend
Yellow: Query proteins
Green: Interaction proteins
Pink line: Own interaction + positive co-expression
Blue line: Own interaction + negative co-expression
Node size reflects how many connections the gene has (hubs are drawn larger). Hover any node to see the annotation of the gene it stands for (PANTHER / InterPro / GO description, or NR when the others are absent) and a link to its gene page.
📋 View Detailed Network Information
Co-expressed Genes of g2220.t1
Gene ID Description PCC Relationship
g2220.t1FOLATE RECEPTOR1positive
g5566.t1LEUCINE-RICH REPEAT SERINE/THREONINE-PROTEIN KINASE 10.95positive
g8218.t1RNA POLYMERASE II-ASSOCIATED PROTEIN 10.93positive
g33674.t1--0.93positive
g1971.t1COILED-COIL DOMAIN-CONTAINING PROTEIN 510.93positive
g11620.t1--0.92positive
g17837.t1WD REPEAT-CONTAINING PROTEIN 610.92positive
g28249.t1BATTENIN0.92positive
g22005.t1ZINC FINGERS AND HOMEOBOXES PROTEIN 1, ISOFORM 20.91positive
g1943.t1CAMK FAMILY PROTEIN KINASE0.91positive
g27715.t1POLY A -SPECIFIC RIBONUCLEASE/TARGET OF EGR1, MEMBER 10.89positive
g3849.t1DC11 ACN9 HOMOLOG0.87positive
g6022.t1MITOCHONDRIAL ATP SYNTHASE COUPLING FACTOR B0.84positive
g2340.t1BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE0.79positive
Further Analysis for Network Members
Next Step: Dynamic Expression View

What this does. Everything above treats every gene the same way. Dynamic Expression View redraws this same network but colours each node by how much that gene changes between two conditions, so you can see which part of the network responds. It needs one input the network itself does not carry: a per-gene expression ratio.

Where the ratio comes from. CnidoSite holds an RNA-seq expression matrix for this species, so the ratio can be built here rather than elsewhere: pick the samples for each side of your comparison and every gene gets log2((mean of group A + 1) / (mean of group B + 1)). This network has 32 gene pairs and one run of Dynamic Expression View draws at most 10, so the button below carries the 10 with the strongest |PCC|.

Gene pairs carried over (10)
Opens the ratio builder with these pairs already loaded. It computes the ratios, then hands both the pairs and the ratios to the network view in one step.
Or take the pairs by hand
Click to select all, then paste into step 2 of Dynamic Expression View as GeneA GeneB, one pair per line. Its step 3 still needs the expression ratios.
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