Co-expression Network Analysis

Interactive visualization of gene co-expression networks, expression and funtional enrichment analysis.

📊 Global Network of g23171.t1
Network Legend
Yellow: Query proteins
Green: Interaction proteins
Pink line: Own interaction + positive co-expression
Blue line: Own interaction + negative co-expression
Node size reflects how many connections the gene has (hubs are drawn larger). Hover any node to see the annotation of the gene it stands for (PANTHER / InterPro / GO description, or NR when the others are absent) and a link to its gene page.
📋 View Detailed Network Information
Co-expressed Genes of g23171.t1
Gene ID Description PCC Relationship
g23171.t1--1positive
g2461.t1-0.96positive
g23590.t1TYROSINE-PROTEIN KINASE RECEPTOR0.96positive
g2952.t1CENTROSOMAL PROTEIN 20.96positive
g13139.t1MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED0.96positive
g2719.t1GLR0591 PROTEIN0.96positive
g2936.t1CENTROSOMAL PROTEIN 20.96positive
g16657.t1RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE0.96positive
g601.t1TETRATRICOPEPTIDE REPEAT PROTEIN 130.95positive
g16535.t1SI:CH211-108C17.2-RELATED-RELATED0.93positive
g6669.t1XK-RELATED PROTEIN0.93positive
g33863.t1ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN0.91positive
g17263.t1--0.90positive
Further Analysis for Network Members
Next Step: Dynamic Expression View

What this does. Everything above treats every gene the same way. Dynamic Expression View redraws this same network but colours each node by how much that gene changes between two conditions, so you can see which part of the network responds. It needs one input the network itself does not carry: a per-gene expression ratio.

Where the ratio comes from. CnidoSite holds an RNA-seq expression matrix for this species, so the ratio can be built here rather than elsewhere: pick the samples for each side of your comparison and every gene gets log2((mean of group A + 1) / (mean of group B + 1)). This network has 26 gene pairs and one run of Dynamic Expression View draws at most 10, so the button below carries the 10 with the strongest |PCC|.

Gene pairs carried over (10)
Opens the ratio builder with these pairs already loaded. It computes the ratios, then hands both the pairs and the ratios to the network view in one step.
Or take the pairs by hand
Click to select all, then paste into step 2 of Dynamic Expression View as GeneA GeneB, one pair per line. Its step 3 still needs the expression ratios.
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