Co-expression Network Analysis

Interactive visualization of gene co-expression networks, expression and funtional enrichment analysis.

📊 Global Network of g25459.t1
Network Legend
Yellow: Query proteins
Green: Interaction proteins
Pink line: Own interaction + positive co-expression
Blue line: Own interaction + negative co-expression
Node size reflects how many connections the gene has (hubs are drawn larger). Hover any node to see the annotation of the gene it stands for (PANTHER / InterPro / GO description, or NR when the others are absent) and a link to its gene page.
📋 View Detailed Network Information
Co-expressed Genes of g25459.t1
Gene ID Description PCC Relationship
g25459.t1--1positive
g402.t1--0.93positive
g4160.t1--0.93positive
g16764.t1YY1 ASSOCIATED PROTEIN-RELATED0.93positive
g6346.t1MERLIN/MOESIN/EZRIN/RADIXIN0.93positive
g16112.t1MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE0.93positive
g4161.t1MULTICOPPER OXIDASE-RELATED0.93positive
g13539.t1OCCLUDIN AND RNA POLYMERASE II ELONGATION FACTOR ELL0.93positive
g3928.t1BEN DOMAIN-CONTAINING PROTEIN 30.93positive
Further Analysis for Network Members
Next Step: Dynamic Expression View

What this does. Everything above treats every gene the same way. Dynamic Expression View redraws this same network but colours each node by how much that gene changes between two conditions, so you can see which part of the network responds. It needs one input the network itself does not carry: a per-gene expression ratio.

Where the ratio comes from. CnidoSite holds an RNA-seq expression matrix for this species, so the ratio can be built here rather than elsewhere: pick the samples for each side of your comparison and every gene gets log2((mean of group A + 1) / (mean of group B + 1)). This network has 27 gene pairs and one run of Dynamic Expression View draws at most 10, so the button below carries the 10 with the strongest |PCC|.

Gene pairs carried over (10)
Opens the ratio builder with these pairs already loaded. It computes the ratios, then hands both the pairs and the ratios to the network view in one step.
Or take the pairs by hand
Click to select all, then paste into step 2 of Dynamic Expression View as GeneA GeneB, one pair per line. Its step 3 still needs the expression ratios.
TOP