Co-expression Network Analysis

Interactive visualization of gene co-expression networks, expression and funtional enrichment analysis.

📊 Global Network of g28890.t1
Network Legend
Yellow: Query proteins
Green: Interaction proteins
Pink line: Own interaction + positive co-expression
Blue line: Own interaction + negative co-expression
Node size reflects how many connections the gene has (hubs are drawn larger). Hover any node to see the annotation of the gene it stands for (PANTHER / InterPro / GO description, or NR when the others are absent) and a link to its gene page.
📋 View Detailed Network Information
Co-expressed Genes of g28890.t1
Gene ID Description PCC Relationship
g28890.t1PROTEIN MIS12 HOMOLOG1positive
g531.t1DNAJ HOMOLOG SUBFAMILY C MEMBER 220.93positive
g13225.t1RING BOX0.92positive
g14986.t1PROTEIN DISULFIDE ISOMERASE0.92positive
g11903.t1HEAT SHOCK PROTEIN 70KDA0.91positive
g28579.t1--0.90positive
g8343.t1SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC110.90positive
g11344.t1THIOREDOXIN PEROXIDASE0.89positive
g25529.t1--0.89positive
g30184.t1PROLYL 4-HYDROXYLASE ALPHA SUBUNIT0.89positive
g17125.t1SOX TRANSCRIPTION FACTOR0.89positive
g28082.t1PERIODIC TRYPTOPHAN PROTEIN 10.89positive
g9860.t1ZINC FINGER PROTEIN 5930.89positive
g16264.t1NUCLEAR MOVEMENT PROTEIN NUDC0.89positive
g1473.t11-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED0.87positive
g25334.t1--0.86positive
g14714.t1KINESIN-LIKE PROTEIN KIF110.83positive
Further Analysis for Network Members
Next Step: Dynamic Expression View

What this does. Everything above treats every gene the same way. Dynamic Expression View redraws this same network but colours each node by how much that gene changes between two conditions, so you can see which part of the network responds. It needs one input the network itself does not carry: a per-gene expression ratio.

Where the ratio comes from. CnidoSite holds an RNA-seq expression matrix for this species, so the ratio can be built here rather than elsewhere: pick the samples for each side of your comparison and every gene gets log2((mean of group A + 1) / (mean of group B + 1)). This network has 60 gene pairs and one run of Dynamic Expression View draws at most 10, so the button below carries the 10 with the strongest |PCC|.

Gene pairs carried over (10)
Opens the ratio builder with these pairs already loaded. It computes the ratios, then hands both the pairs and the ratios to the network view in one step.
Or take the pairs by hand
Click to select all, then paste into step 2 of Dynamic Expression View as GeneA GeneB, one pair per line. Its step 3 still needs the expression ratios.
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