Co-expression Network Analysis

Interactive visualization of gene co-expression networks, expression and funtional enrichment analysis.

📊 Global Network of g3052.t1
Network Legend
Yellow: Query proteins
Green: Interaction proteins
Pink line: Own interaction + positive co-expression
Blue line: Own interaction + negative co-expression
Node size reflects how many connections the gene has (hubs are drawn larger). Hover any node to see the annotation of the gene it stands for (PANTHER / InterPro / GO description, or NR when the others are absent) and a link to its gene page.
📋 View Detailed Network Information
Co-expressed Genes of g3052.t1
Gene ID Description PCC Relationship
g3052.t1D-GLUTAMATE CYCLASE, MITOCHONDRIAL1positive
g7306.t1HEAT SHOCK PROTEIN 70KDA0.90positive
g27.t1ARYLSULFATASE0.89positive
g13307.t1ALDEHYDE DEHYDROGENASE0.88positive
g33192.t1HEAT SHOCK PROTEIN 70KDA0.88positive
g34965.t1VALACYCLOVIR HYDROLASE0.88positive
g21233.t1HOMOSERINE O-ACETYLTRANSFERASE0.88positive
g24136.t1MICROTUBULE-ASSOCIATED PROTEIN RP/EB FAMILY MEMBER0.88positive
g21068.t1TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE0.86positive
g19551.t1FUSELESS, ISOFORM A0.86positive
g24413.t1TYROSINE-PROTEIN KINASE RECEPTOR0.75positive
g8773.t1REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN0.72positive
Further Analysis for Network Members
Next Step: Dynamic Expression View

What this does. Everything above treats every gene the same way. Dynamic Expression View redraws this same network but colours each node by how much that gene changes between two conditions, so you can see which part of the network responds. It needs one input the network itself does not carry: a per-gene expression ratio.

Where the ratio comes from. CnidoSite holds an RNA-seq expression matrix for this species, so the ratio can be built here rather than elsewhere: pick the samples for each side of your comparison and every gene gets log2((mean of group A + 1) / (mean of group B + 1)). This network has 29 gene pairs and one run of Dynamic Expression View draws at most 10, so the button below carries the 10 with the strongest |PCC|.

Gene pairs carried over (10)
Opens the ratio builder with these pairs already loaded. It computes the ratios, then hands both the pairs and the ratios to the network view in one step.
Or take the pairs by hand
Click to select all, then paste into step 2 of Dynamic Expression View as GeneA GeneB, one pair per line. Its step 3 still needs the expression ratios.
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