Co-expression Network Analysis

Interactive visualization of gene co-expression networks, expression and funtional enrichment analysis.

📊 Global Network of g4456.t1
Network Legend
Yellow: Query proteins
Green: Interaction proteins
Pink line: Own interaction + positive co-expression
Blue line: Own interaction + negative co-expression
Node size reflects how many connections the gene has (hubs are drawn larger). Hover any node to see the annotation of the gene it stands for (PANTHER / InterPro / GO description, or NR when the others are absent) and a link to its gene page.
📋 View Detailed Network Information
Co-expressed Genes of g4456.t1
Gene ID Description PCC Relationship
g4456.t1ALPHA-MANNOSIDE BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE1positive
g34967.t1GTP-BINDING PROTEIN-RELATED0.95positive
g3269.t1DEHYDROGENASE RELATED0.95positive
g11027.t1ENOLASE0.95positive
g35048.t1ENOYL-COA HYDRATASE-RELATED0.95positive
g14981.t1ANTIGEN MLAA-22-RELATED0.94positive
g12754.t1GLR0591 PROTEIN0.94positive
g27862.t1DEHYDROGENASE/REDUCTASE (SDR FAMILY) MEMBER 40.94positive
g10208.t1CORTACTIN AND DREBRIN0.94positive
g15394.t1PROTEIN CBG204880.94positive
g27128.t1PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR0.94positive
g24767.t1--0.94positive
g27964.t1SECRETED MODULAR CALCIUM-BINDING PROTEIN0.93positive
g4960.t1PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN0.93positive
g341.t1NOTCH LIGAND FAMILY MEMBER0.93positive
g21458.t1SEC100.93positive
g1039.t1SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA0.93positive
g2791.t1SH2-SH3 ADAPTOR PROTEIN-RELATED0.92positive
g4078.t1O-METHYLTRANSFERASE-RELATED0.92positive
g5463.t1S-FORMYLGLUTATHIONE HYDROLASE0.92positive
g21457.t1SEC100.92positive
g3902.t1LEUCINE AMINOPEPTIDASE-RELATED0.92positive
g11956.t1ATP-DEPENDENT RNA HELICASE DBP30.92positive
g20670.t1BRCA1-ASSOCIATED PROTEIN0.91positive
g15751.t1UNCHARACTERIZED0.91positive
g28293.t1LON PROTEASE0.91positive
g17331.t1--0.91positive
g12482.t12-OXOGLUTARATE DEHYDROGENASE0.91positive
g7115.t1ATAXIA TELANGIECTASIA MUTATED ATM -RELATED0.91positive
g29860.t1BETA-ALA-HIS DIPEPTIDASE0.91positive
g4998.t1NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED0.90positive
g14308.t1ATP-DEPENDENT PROTEASE0.90positive
g7234.t1UNCHARACTERIZED0.90positive
g8533.t1PROLINE-RICH TRANSMEMBRANE PROTEIN 4-RELATED0.89positive
g2383.t1NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED0.89positive
g10329.t1BARDET-BIEDL SYNDROME PROTEIN 50.89positive
g11953.t1C2H2-TYPE DOMAIN-CONTAINING PROTEIN0.89positive
g5144.t1SUBGROUP IIII AMINOTRANSFERASE0.89positive
g21691.t1UNCHARACTERIZED0.89positive
g12752.t1--0.87positive
g10546.t1HEPARANASE0.86positive
Further Analysis for Network Members
Next Step: Dynamic Expression View

What this does. Everything above treats every gene the same way. Dynamic Expression View redraws this same network but colours each node by how much that gene changes between two conditions, so you can see which part of the network responds. It needs one input the network itself does not carry: a per-gene expression ratio.

Where the ratio comes from. CnidoSite holds an RNA-seq expression matrix for this species, so the ratio can be built here rather than elsewhere: pick the samples for each side of your comparison and every gene gets log2((mean of group A + 1) / (mean of group B + 1)). This network has 265 gene pairs and one run of Dynamic Expression View draws at most 10, so the button below carries the 10 with the strongest |PCC|.

Gene pairs carried over (10)
Opens the ratio builder with these pairs already loaded. It computes the ratios, then hands both the pairs and the ratios to the network view in one step.
Or take the pairs by hand
Click to select all, then paste into step 2 of Dynamic Expression View as GeneA GeneB, one pair per line. Its step 3 still needs the expression ratios.
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