Co-expression Network Analysis

Interactive visualization of gene co-expression networks, expression and funtional enrichment analysis.

📊 Global Network of g7231.t1
Network Legend
Yellow: Query proteins
Green: Interaction proteins
Pink line: Own interaction + positive co-expression
Blue line: Own interaction + negative co-expression
Node size reflects how many connections the gene has (hubs are drawn larger). Hover any node to see the annotation of the gene it stands for (PANTHER / InterPro / GO description, or NR when the others are absent) and a link to its gene page.
📋 View Detailed Network Information
Co-expressed Genes of g7231.t1
Gene ID Description PCC Relationship
g7231.t1VESICULAR, OVEREXPRESSED IN CANCER, PROSURVIVAL PROTEIN 11positive
g28550.t1EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G0.95positive
g5212.t1POLYCOMB GROUP PROTEIN PC0.93positive
g28086.t1DNAJ HOMOLOG SUBFAMILY B MEMBER 20.92positive
g4897.t1CRUMBS FAMILY MEMBER0.92positive
g30678.t1CHROMOSOME 20 ORF85 FAMILY MEMBER0.92positive
g14204.t1MYELIN TRANSCRIPTION FACTOR 1-RELATED0.92positive
g16627.t1EPSIN/ENT-RELATED0.90positive
g8516.t1LD33804P0.89positive
g3983.t1KELCH PROTEIN0.89positive
g19656.t1TRANSCRIPTION FACTOR CP20.88positive
g3237.t1INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED0.87positive
g22995.t1--0.87positive
g17065.t1ATP-BINDING CASSETTE SUB-FAMILY C0.86positive
Further Analysis for Network Members
Next Step: Dynamic Expression View

What this does. Everything above treats every gene the same way. Dynamic Expression View redraws this same network but colours each node by how much that gene changes between two conditions, so you can see which part of the network responds. It needs one input the network itself does not carry: a per-gene expression ratio.

Where the ratio comes from. CnidoSite holds an RNA-seq expression matrix for this species, so the ratio can be built here rather than elsewhere: pick the samples for each side of your comparison and every gene gets log2((mean of group A + 1) / (mean of group B + 1)). This network has 53 gene pairs and one run of Dynamic Expression View draws at most 10, so the button below carries the 10 with the strongest |PCC|.

Gene pairs carried over (10)
Opens the ratio builder with these pairs already loaded. It computes the ratios, then hands both the pairs and the ratios to the network view in one step.
Or take the pairs by hand
Click to select all, then paste into step 2 of Dynamic Expression View as GeneA GeneB, one pair per line. Its step 3 still needs the expression ratios.
TOP