Co-expression Network Analysis

Interactive visualization of gene co-expression networks, expression and funtional enrichment analysis.

📊 Global Network of g8582.t1
Network Legend
Yellow: Query proteins
Green: Interaction proteins
Pink line: Own interaction + positive co-expression
Blue line: Own interaction + negative co-expression
Node size reflects how many connections the gene has (hubs are drawn larger). Hover any node to see the annotation of the gene it stands for (PANTHER / InterPro / GO description, or NR when the others are absent) and a link to its gene page.
📋 View Detailed Network Information
Co-expressed Genes of g8582.t1
Gene ID Description PCC Relationship
g8582.t1PORCUPINE1positive
g27333.t1HISTIDINE TRIAD HIT PROTEIN MEMBER0.90positive
g409.t1DET1 HOMOLOG DE-ETIOLATED-1 HOMOLOG0.90positive
g11118.t1SAND PROTEIN-RELATED0.89positive
g231.t1GTP-BINDING PROTEIN ALPHA SUBUNIT0.89positive
g25287.t1PALMITOYLTRANSFERASE ZDHHC160.89positive
g5164.t1UNCHARACTERIZED0.89positive
g3215.t1CALCIUM-BINDING PROTEIN 39-RELATED0.88positive
g36057.t1F-BOX ONLY PROTEIN 380.88positive
g35165.t1--0.87positive
g3542.t1--0.85positive
g21543.t1UNCHARACTERIZED0.81positive
Further Analysis for Network Members
Next Step: Dynamic Expression View

What this does. Everything above treats every gene the same way. Dynamic Expression View redraws this same network but colours each node by how much that gene changes between two conditions, so you can see which part of the network responds. It needs one input the network itself does not carry: a per-gene expression ratio.

Where the ratio comes from. CnidoSite holds an RNA-seq expression matrix for this species, so the ratio can be built here rather than elsewhere: pick the samples for each side of your comparison and every gene gets log2((mean of group A + 1) / (mean of group B + 1)). This network has 28 gene pairs and one run of Dynamic Expression View draws at most 10, so the button below carries the 10 with the strongest |PCC|.

Gene pairs carried over (10)
Opens the ratio builder with these pairs already loaded. It computes the ratios, then hands both the pairs and the ratios to the network view in one step.
Or take the pairs by hand
Click to select all, then paste into step 2 of Dynamic Expression View as GeneA GeneB, one pair per line. Its step 3 still needs the expression ratios.
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