Genomic Location: :...
NR annotation: 5AQF_A, Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues [Homo sapiens]
| CDS | |||||
| Transcript |
| Protein |
| Uniprot term | Description |
|---|---|
| A2Q0Z1 | Heat shock cognate 71 kDa protein OS=Equus caballus OX=9796 GN=HSPA8 PE=2 SV=1 |
| P11142 | Heat shock cognate 71 kDa protein OS=Homo sapiens OX=9606 GN=HSPA8 PE=1 SV=1 |
| P63017 | Heat shock cognate 71 kDa protein OS=Mus musculus OX=10090 GN=Hspa8 PE=1 SV=1 |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF00078 | RVT_1 | Reverse transcriptase (RNA-dependent DNA polymerase) | Domain | Interproscan |
| PF03184 | DDE_1 | DDE superfamily endonuclease | Family | Interproscan |
| PF00067 | p450 | Cytochrome P450 | Domain | Interproscan |
| PF00665 | rve | Integrase core domain | Domain | Interproscan |
| PF17921 | Integrase_H2C2 | Integrase zinc binding domain | Domain | Interproscan |
| PF03372 | Exo_endo_phos | Endonuclease/Exonuclease/phosphatase family | Domain | Interproscan |
| PF00175 | NAD_binding_1 | Oxidoreductase NAD-binding domain | Domain | Interproscan |
| PF00258 | Flavodoxin_1 | Flavodoxin | Domain | Interproscan |
| PF00667 | FAD_binding_1 | FAD binding domain | Domain | Interproscan |
| PF00012 | HSP70 | Hsp70 protein | Family | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR053134 | Family | RNA-directed DNA polymerase homolog | Interproscan |
| IPR043502 | Homologous_superfamily | DNA/RNA polymerase superfamily | Interproscan |
| IPR000477 | Domain | Reverse transcriptase domain | Interproscan |
| IPR050863 | Family | Centromere and Transposable Element-Derived Protein | Interproscan |
| IPR004875 | Domain | DDE superfamily endonuclease domain | Interproscan |
| IPR017972 | Conserved_site | Cytochrome P450, conserved site | Interproscan |
| IPR001128 | Family | Cytochrome P450 | Interproscan |
| IPR002401 | Family | Cytochrome P450, E-class, group I | Interproscan |
| IPR036396 | Homologous_superfamily | Cytochrome P450 superfamily | Interproscan |
| IPR050182 | Family | Cytochrome P450 family 2 | Interproscan |
| IPR036397 | Homologous_superfamily | Ribonuclease H superfamily | Interproscan |
| IPR012337 | Homologous_superfamily | Ribonuclease H-like superfamily | Interproscan |
| IPR001584 | Domain | Integrase, catalytic core | Interproscan |
| IPR052160 | Family | Gypsy Retrotransposon Integrase-like | Interproscan |
| IPR041588 | Domain | Integrase zinc-binding domain | Interproscan |
| IPR036691 | Homologous_superfamily | Endonuclease/exonuclease/phosphatase superfamily | Interproscan |
| IPR005135 | Domain | Endonuclease/exonuclease/phosphatase | Interproscan |
| IPR001094 | Domain | Flavodoxin-like | Interproscan |
| IPR017938 | Homologous_superfamily | Riboflavin synthase-like beta-barrel | Interproscan |
| IPR039261 | Homologous_superfamily | Ferredoxin-NADP reductase (FNR), nucleotide-binding domain | Interproscan |
| IPR001433 | Domain | Oxidoreductase FAD/NAD(P)-binding | Interproscan |
| IPR001709 | Domain | Flavoprotein pyridine nucleotide cytochrome reductase | Interproscan |
| IPR023173 | Homologous_superfamily | NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily | Interproscan |
| IPR017927 | Domain | FAD-binding domain, ferredoxin reductase-type | Interproscan |
| IPR008254 | Domain | Flavodoxin/nitric oxide synthase | Interproscan |
| IPR003097 | Domain | Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding | Interproscan |
| IPR029039 | Homologous_superfamily | Flavoprotein-like superfamily | Interproscan |
| IPR043129 | Homologous_superfamily | ATPase, nucleotide binding domain | Interproscan |
| IPR018181 | Conserved_site | Heat shock protein 70, conserved site | Interproscan |
| IPR013126 | Family | Heat shock protein 70 family | Interproscan |
| IPR026630 | Family | EPM2A-interacting protein 1/ZBED8-like | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR24559 | TRANSPOSON TY3-I GAG-POL POLYPROTEIN | Interproscan |
| PTHR21301 | REVERSE TRANSCRIPTASE | Interproscan |
| PTHR19303 | TRANSPOSON | Interproscan |
| PTHR24300 | CYTOCHROME P450 508A4-RELATED | Interproscan |
| PTHR47266 | ENDONUCLEASE-RELATED | Interproscan |
| PTHR46670 | ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN | Interproscan |
| PTHR19384 | NITRIC OXIDE SYNTHASE-RELATED | Interproscan |
| PTHR47027 | REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN | Interproscan |
| PTHR19375 | HEAT SHOCK PROTEIN 70KDA | Interproscan |
| PTHR45913 | EPM2A-INTERACTING PROTEIN 1 | Interproscan |
| GO terms | Category | Description | Source |
|---|---|---|---|
| GO:0003677 | Molecular Function | DNA binding | Interproscan |
| GO:0005634 | Cellular Component | nucleus | Interproscan |
| GO:0003676 | Molecular Function | nucleic acid binding | Interproscan |
| GO:0005506 | Molecular Function | iron ion binding | Interproscan |
| GO:0016705 | Molecular Function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | Interproscan |
| GO:0004497 | Molecular Function | monooxygenase activity | Interproscan |
| GO:0020037 | Molecular Function | heme binding | Interproscan |
| GO:0005737 | Cellular Component | cytoplasm | Interproscan |
| GO:0006082 | Biological Process | organic acid metabolic process | Interproscan |
| GO:0006805 | Biological Process | xenobiotic metabolic process | Interproscan |
| GO:0016712 | Molecular Function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | Interproscan |
| GO:0043231 | Cellular Component | intracellular membrane-bounded organelle | Interproscan |
| GO:0015074 | Biological Process | DNA integration | Interproscan |
| GO:0003824 | Molecular Function | catalytic activity | Interproscan |
| GO:0010181 | Molecular Function | FMN binding | Interproscan |
| GO:0003958 | Molecular Function | NADPH-hemoprotein reductase activity | Interproscan |
| GO:0005829 | Cellular Component | cytosol | Interproscan |
| GO:0009725 | Biological Process | response to hormone | Interproscan |
| GO:0016491 | Molecular Function | oxidoreductase activity | Interproscan |
| GO:0050660 | Molecular Function | flavin adenine dinucleotide binding | Interproscan |
| GO:0005524 | Molecular Function | ATP binding | Interproscan |
| GO:0005886 | Cellular Component | plasma membrane | Interproscan |
| GO:0140662 | Molecular Function | ATP-dependent protein folding chaperone | Interproscan |
| KO | Enzyme | Enzyme ID | pathway | mapID | Source |
|---|---|---|---|---|---|
| K00327 | POR; NADPH-ferrihemoprotein reductase | EC:1.6.2.4 | Enzymes with EC numbers | - | deepkoala |