Gene detail

Detailed information of BRAKERKREP00000016253.1 in Hydra viridissima

Genomic Location: not available for this species
NR annotation: XP_012557792.1, C-1-tetrahydrofolate synthase, cytoplasmic isoform X1 [Hydra vulgaris]
Species Hydra viridissima · all data for this species · gene families

Sequence

CDS

Transcript

Protein

UniProt (Swiss-Prot top hit)

UniProt accession	Description
P11586	C-1-tetrahydrofolate synthase, cytoplasmic OS=Homo sapiens OX=9606 GN=MTHFD1 PE=1 SV=4
Q5R8P0	C-1-tetrahydrofolate synthase, cytoplasmic OS=Pongo abelii OX=9601 GN=MTHFD1 PE=2 SV=3
P27653	C-1-tetrahydrofolate synthase, cytoplasmic OS=Rattus norvegicus OX=10116 GN=Mthfd1 PE=1 SV=3

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0001689 (this species only)

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF02882 all species →	THF_DHG_CYH_C	Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain	Domain	Interproscan
PF00763 all species →	THF_DHG_CYH	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain	Domain	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR020867 all species →	Conserved_site	Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site	Interproscan
IPR036291 all species →	Homologous_superfamily	NAD(P)-binding domain superfamily	Interproscan
IPR020631 all species →	Domain	Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain	Interproscan
IPR000672 all species →	Family	Tetrahydrofolate dehydrogenase/cyclohydrolase	Interproscan
IPR046346 all species →	Homologous_superfamily	Aminoacid dehydrogenase-like, N-terminal domain superfamily	Interproscan
IPR020630 all species →	Domain	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR48099 all species →	C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0003824 all species →	Molecular Function	catalytic activity	Interproscan
GO:0004488 all species →	Molecular Function	methylenetetrahydrofolate dehydrogenase (NADP+) activity	Interproscan
GO:0004477 all species →	Molecular Function	methenyltetrahydrofolate cyclohydrolase activity	Interproscan
GO:0005829 all species →	Cellular Component	cytosol	Interproscan
GO:0035999 all species →	Biological Process	tetrahydrofolate interconversion	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

KO	Enzyme	Enzyme ID	Pathway	Map ID	Source
K01491	folD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase	EC:1.5.1.5 EC:3.5.4.9	One carbon pool by folate	ko00670	deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Expression pattern (RNA-seq)

Transcript abundance of BRAKERKREP00000016253.1 across 29 RNA-seq samples of Hydra viridissima. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.

29Samples

18TPM > 0

7Conditions

80.2Max TPM

11.6Mean TPM

By condition

Condition	Samples	TPM > 0	Mean TPM	Max TPM
whole body	18	8	12.15	80.16
Whole	6	6	11.51	15.66
aposymbioic hydra M9 strain · aposymbioic hydra rep1	1	1	19.76	19.76
aposymbioic hydra M9 strain · aposymbioic hydra rep2	1	1	13.80	13.80
symbioic hydra M9 strain · symbioic hydra rep1	1	1	14.21	14.21
symbioic hydra M9 strain · symbioic hydra rep2	1	1	0.51	0.51
unannotated	1	0	0.00	0.00

Per sample · hover a bar for the full sample record · show / hide the sample table

SRA run	Condition	Tissue	Developmental stage	Treatment	Study	TPM
SRR21134052	whole body	whole body	not recorded	not recorded	SRP392977	80.16
SRR21134060	whole body	whole body	not recorded	not recorded	SRP392977	36.96
SRR21134050	whole body	whole body	not recorded	not recorded	SRP392977	32.49
SRR21134061	whole body	whole body	not recorded	not recorded	SRP392977	26.17
SRR21134059	whole body	whole body	not recorded	not recorded	SRP392977	23.06
SRR21134064	whole body	whole body	not recorded	not recorded	SRP392977	18.31
SRR21134051	whole body	whole body	not recorded	not recorded	SRP392977	0.96
SRR21134056	whole body	whole body	not recorded	not recorded	SRP392977	0.51
SRR21134053	whole body	whole body	not recorded	not recorded	SRP392977	0.00
SRR21134054	whole body	whole body	not recorded	not recorded	SRP392977	0.00
SRR21134055	whole body	whole body	not recorded	not recorded	SRP392977	0.00
SRR21134057	whole body	whole body	not recorded	not recorded	SRP392977	0.00
SRR21134058	whole body	whole body	not recorded	not recorded	SRP392977	0.00
SRR21134062	whole body	whole body	not recorded	not recorded	SRP392977	0.00
SRR21134063	whole body	whole body	not recorded	not recorded	SRP392977	0.00
SRR21134065	whole body	whole body	not recorded	not recorded	SRP392977	0.00
SRR21134066	whole body	whole body	not recorded	not recorded	SRP392977	0.00
SRR21134067	whole body	whole body	not recorded	not recorded	SRP392977	0.00
SRR10058803	Whole	Whole	not recorded	not recorded	SRP220397	15.66
SRR10058804	Whole	Whole	not recorded	not recorded	SRP220397	11.85
SRR10058807	Whole	Whole	not recorded	not recorded	SRP220397	11.64
SRR10058802	Whole	Whole	not recorded	not recorded	SRP220397	10.80
SRR10058806	Whole	Whole	not recorded	not recorded	SRP220397	9.81
SRR10058805	Whole	Whole	not recorded	not recorded	SRP220397	9.31
DRR048593	aposymbioic hydra M9 strain · aposymbioic hydra rep1	not recorded	not recorded	aposymbioic hydra rep1	DRP003902	19.76
DRR048594	aposymbioic hydra M9 strain · aposymbioic hydra rep2	not recorded	not recorded	aposymbioic hydra rep2	DRP003902	13.80
DRR048595	symbioic hydra M9 strain · symbioic hydra rep1	not recorded	not recorded	symbioic hydra rep1	DRP003902	14.21
DRR048596	symbioic hydra M9 strain · symbioic hydra rep2	not recorded	not recorded	symbioic hydra rep2	DRP003902	0.51
ERR13389755	unannotated	not recorded	not recorded	not recorded	ERP162636	0.00

Source: CnidoSite RNA-seq expression matrices (HVIRI_TPM, StringTie quantification over 29 runs), joined to SRA sample metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped by the descriptor carried in the expression matrix itself.