Genomic Location: QPEY01000239.1:104631...113619
NR annotation: XP_047135003.1, phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha-like isoform X2 [Hydra vulgaris]
Species Hydra viridissima · all data for this species · gene families
| CDS |
| BRAKERKRET00000021068 |
| Transcript |
| BRAKERKRET00000021068 |
| Protein |
| BRAKERKREP00000021068.1 |
| UniProt accession | Description |
|---|---|
| O00443 | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha OS=Homo sapiens OX=9606 GN=PIK3C2A PE=1 SV=2 |
| Q5RAY1 | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha OS=Pongo abelii OX=9601 GN=PIK3C2A PE=2 SV=1 |
| Q61194 | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha OS=Mus musculus OX=10090 GN=Pik3c2a PE=1 SV=2 |
| Family type | Membership / link |
|---|---|
| Orthogroup (gene family) | OG0001304 (this species only) · gene tree & orthology |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF00454 all species → | PI3_PI4_kinase | Phosphatidylinositol 3- and 4-kinase | Family | Interproscan |
| PF00787 all species → | PX | PX domain | Domain | Interproscan |
| PF00168 all species → | C2 | C2 domain | Domain | Interproscan |
| PF00792 all species → | PI3K_C2 | Phosphoinositide 3-kinase C2 | Domain | Interproscan |
| PF00613 all species → | PI3Ka | Phosphoinositide 3-kinase family, accessory domain (PIK domain) | Repeat | Interproscan |
| PF00794 all species → | PI3K_rbd | PI3-kinase family, ras-binding domain | Domain | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR035892 all species → | Homologous_superfamily | C2 domain superfamily | Interproscan |
| IPR015433 all species → | Family | Phosphatidylinositol kinase | Interproscan |
| IPR000403 all species → | Domain | Phosphatidylinositol 3-/4-kinase, catalytic domain | Interproscan |
| IPR042236 all species → | Homologous_superfamily | Phosphoinositide 3-kinase, accessory (PIK) domain superfamily | Interproscan |
| IPR002420 all species → | Domain | C2 phosphatidylinositol 3-kinase-type domain | Interproscan |
| IPR001683 all species → | Domain | Phox homology | Interproscan |
| IPR016024 all species → | Homologous_superfamily | Armadillo-type fold | Interproscan |
| IPR036871 all species → | Homologous_superfamily | PX domain superfamily | Interproscan |
| IPR001263 all species → | Domain | Phosphoinositide 3-kinase, accessory (PIK) domain | Interproscan |
| IPR018936 all species → | Conserved_site | Phosphatidylinositol 3/4-kinase, conserved site | Interproscan |
| IPR000008 all species → | Domain | C2 domain | Interproscan |
| IPR029071 all species → | Homologous_superfamily | Ubiquitin-like domain superfamily | Interproscan |
| IPR036940 all species → | Homologous_superfamily | Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily | Interproscan |
| IPR000341 all species → | Domain | Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain | Interproscan |
| IPR011009 all species → | Homologous_superfamily | Protein kinase-like domain superfamily | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR10048 all species → | PHOSPHATIDYLINOSITOL KINASE | Interproscan |
| GO term | Category | Description | Source |
|---|---|---|---|
| GO:0005737 all species → | Cellular Component | cytoplasm | Interproscan |
| GO:0005886 all species → | Cellular Component | plasma membrane | Interproscan |
| GO:0005942 all species → | Cellular Component | phosphatidylinositol 3-kinase complex | Interproscan |
| GO:0014065 all species → | Biological Process | obsolete phosphatidylinositol 3-kinase signaling | Interproscan |
| GO:0016020 all species → | Cellular Component | membrane | Interproscan |
| GO:0016303 all species → | Molecular Function | 1-phosphatidylinositol-3-kinase activity | Interproscan |
| GO:0016477 all species → | Biological Process | cell migration | Interproscan |
| GO:0035005 all species → | Molecular Function | 1-phosphatidylinositol-4-phosphate 3-kinase activity | Interproscan |
| GO:0036092 all species → | Biological Process | phosphatidylinositol-3-phosphate biosynthetic process | Interproscan |
| GO:0046854 all species → | Biological Process | phosphatidylinositol phosphate biosynthetic process | Interproscan |
| GO:0048015 all species → | Biological Process | phosphatidylinositol-mediated signaling | Interproscan |
| GO:0052742 all species → | Molecular Function | phosphatidylinositol kinase activity | Interproscan |
| GO:0035091 all species → | Molecular Function | phosphatidylinositol binding | Interproscan |
| GO:0016301 all species → | Molecular Function | kinase activity | Interproscan |
| KO | Enzyme | Enzyme ID | Pathway | Map ID | Source |
|---|---|---|---|---|---|
| K00923 | PIK3C2; phosphatidylinositol-4-phosphate 3-kinase | EC:2.7.1.154 | Salmonella infection | ko05132 | deepkoala |
Transcript abundance of BRAKERKREP00000021068.1 across 29 RNA-seq samples of Hydra viridissima. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.
| Condition | Samples | TPM > 0 | Mean TPM | Max TPM | Mean, relative to max |
|---|---|---|---|---|---|
| whole body | 18 | 0 | 0.00 | 0.00 | |
| Whole | 6 | 2 | 0.05 | 0.16 | |
| aposymbioic hydra M9 strain · aposymbioic hydra rep1 | 1 | 0 | 0.00 | 0.00 | |
| aposymbioic hydra M9 strain · aposymbioic hydra rep2 | 1 | 1 | 0.16 | 0.16 | |
| symbioic hydra M9 strain · symbioic hydra rep1 | 1 | 1 | 0.15 | 0.15 | |
| symbioic hydra M9 strain · symbioic hydra rep2 | 1 | 0 | 0.00 | 0.00 | |
| unannotated | 1 | 0 | 0.00 | 0.00 |
| SRA run | Condition | Tissue | Developmental stage | Treatment | Study | TPM |
|---|---|---|---|---|---|---|
| SRR21134050 | whole body | whole body | not recorded | not recorded | SRP392977 | 0.00 |
| SRR21134051 | whole body | whole body | not recorded | not recorded | SRP392977 | 0.00 |
| SRR21134052 | whole body | whole body | not recorded | not recorded | SRP392977 | 0.00 |
| SRR21134053 | whole body | whole body | not recorded | not recorded | SRP392977 | 0.00 |
| SRR21134054 | whole body | whole body | not recorded | not recorded | SRP392977 | 0.00 |
| SRR21134055 | whole body | whole body | not recorded | not recorded | SRP392977 | 0.00 |
| SRR21134056 | whole body | whole body | not recorded | not recorded | SRP392977 | 0.00 |
| SRR21134057 | whole body | whole body | not recorded | not recorded | SRP392977 | 0.00 |
| SRR21134058 | whole body | whole body | not recorded | not recorded | SRP392977 | 0.00 |
| SRR21134059 | whole body | whole body | not recorded | not recorded | SRP392977 | 0.00 |
| SRR21134060 | whole body | whole body | not recorded | not recorded | SRP392977 | 0.00 |
| SRR21134061 | whole body | whole body | not recorded | not recorded | SRP392977 | 0.00 |
| SRR21134062 | whole body | whole body | not recorded | not recorded | SRP392977 | 0.00 |
| SRR21134063 | whole body | whole body | not recorded | not recorded | SRP392977 | 0.00 |
| SRR21134064 | whole body | whole body | not recorded | not recorded | SRP392977 | 0.00 |
| SRR21134065 | whole body | whole body | not recorded | not recorded | SRP392977 | 0.00 |
| SRR21134066 | whole body | whole body | not recorded | not recorded | SRP392977 | 0.00 |
| SRR21134067 | whole body | whole body | not recorded | not recorded | SRP392977 | 0.00 |
| SRR10058805 | Whole | Whole | not recorded | not recorded | SRP220397 | 0.16 |
| SRR10058807 | Whole | Whole | not recorded | not recorded | SRP220397 | 0.12 |
| SRR10058802 | Whole | Whole | not recorded | not recorded | SRP220397 | 0.00 |
| SRR10058803 | Whole | Whole | not recorded | not recorded | SRP220397 | 0.00 |
| SRR10058804 | Whole | Whole | not recorded | not recorded | SRP220397 | 0.00 |
| SRR10058806 | Whole | Whole | not recorded | not recorded | SRP220397 | 0.00 |
| DRR048593 | aposymbioic hydra M9 strain · aposymbioic hydra rep1 | not recorded | not recorded | aposymbioic hydra rep1 | DRP003902 | 0.00 |
| DRR048594 | aposymbioic hydra M9 strain · aposymbioic hydra rep2 | not recorded | not recorded | aposymbioic hydra rep2 | DRP003902 | 0.16 |
| DRR048595 | symbioic hydra M9 strain · symbioic hydra rep1 | not recorded | not recorded | symbioic hydra rep1 | DRP003902 | 0.15 |
| DRR048596 | symbioic hydra M9 strain · symbioic hydra rep2 | not recorded | not recorded | symbioic hydra rep2 | DRP003902 | 0.00 |
| ERR13389755 | unannotated | not recorded | not recorded | not recorded | ERP162636 | 0.00 |
Source: CnidoSite RNA-seq expression matrices (HVIRI_TPM,
StringTie quantification over 29 runs), joined to SRA sample
metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped
by the descriptor carried in the expression matrix itself.
Genes whose expression across the transcriptome samples of Hydra viridissima tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.
| Direction | Partners | Most correlated partner | PCC |
|---|---|---|---|
| Positively correlated | 3 | g11639 | 0.918454073655264 |
| Negatively correlated | 3 | g24806 | -0.42123363175479 |
Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.
Whether this gene can be visualised in the single-cell atlases of Hydra viridissima, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.
No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.
Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.
No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.
Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.
| Analysis | What it does | Status | |
|---|---|---|---|
| Primer design | Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed. | template found | open → |
| BLAST | Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start. | template found | open → |
| Expression heatmap | Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it. | ready | open → |
| Gene family / orthogroup | Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue. | open → | |
| Gene set analysis | Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it. | open → |
