Gene detail

Detailed information of BRAKERXEIP00000029791.1 in Muricea muricata

Genomic Location: chr16:8155604...8174660
NR annotation: XP_028399597.1, epidermal growth factor receptor kinase substrate 8-like isoform X2 [Dendronephthya gigantea]
Species Muricea muricata · all data for this species · gene families

Gene Structure

More details in JBrowse

Sequence

CDS

BRAKERXEIT00000029791

ATGACTGGTGAACCTAGGACAATACCAGCCGGCAATGAACAGCCATCAAATCCTTTCACCTCACCTGTTCGTAGCAACTTCCATATCGAGCATTTAGCTTCTTTTCCTCTCTCTCCCGGAGAAAAAGTAGTTTCTGCTAAGGAACGTCTGCAGAAAGCAAAAGAGTTGATAACAAAGGGTGAACCATGGACGAAAGAAATGGAGCTGTCCGTCACGGACAACGAGCTCGTGCTGCGAGACACGGATACTCAGGAACTCATCGAGAGATATCCTTTATCTCATATCGACTCAGTTCAAGATGTGAATGACGATCCCATGTTAAAAAGCGTCCTGGTCTTCTCAACCATCCAGACGCCTGAGAAATACGCGGCCGTTCATCTTTTCCAGTGTGACAAAGTGCCGGCGAACGTTATTGCTCCTGAAATCAACAAACTAATTTCGAAGCAAAGGGAAAGTCCAAAACTAAACGGTCAAGCACATGGTGTACCTGTTTTACCGCCTCCGCCATCAGAGCCTGCTCCATTACCACCACAGGGCGTCGCAGCGTTTCAGGCTGCCGTTGCAGCTAAGAAAGAACCGGTCGTACCCAGACCCTCACAATCACCGACCAAGATTATGGGTGATCGGTATGGCGATCATTCGTCACCAGACCTCATGGAAGCCTACATCAATCGCGACGTGCATATACTGAATCACTGTATCGACGACATTGAGGAACTCGTGTATCGCGTGAAACAAGTTGCAGAAGCCTGGAAACAACTTGAAACTAAGTACAAAGGAAAGAAAGCCAGAAGTAAAAAACAAGAAGCTGAAGCGATAGAAGCACGTTCACCTTCGCGAGAAGACTTCATTGATGCTTTTCAGAAGTGCAAATATTCCTTCATTCTTTTGGGTAAACTGCGACCTCATATTCAAAATCCCAGCGCACCAGAACTGGTCCACTACCTCATCATGCCGCTCTCGTTGCTCGTCAGATGTACTCGAGGGCCAGAAGAAGCTGGCAAGGTTATCAATCCCCTTATGACATCGGAAAGCATTGAATTACTACGGAGTTCTTTGACAGCTAAAGAAACTGAACTATGGCAGTCACTGGGTCCTGCTTGGACTTTATCAagGAGTAGTCCTCACTGGAACAGCCGTCCTCTAGCAGCATATGAGCCAAAGTTCAGAAGCGGTTGGGTACCACCCGAGATCGTAGGTTCTGGACGAAGTGTGCCTGCAGATGTAGGTGCAGCGGTCGCTGCCAGCGCTGCGGCAAGAGCTGACCACGAGCGAGTCAAGAAGAATTCCAGAGACGAGGCTAGGAGCAACCCAGTTGTCTTGGACGCTgcctcaaaattcaaaaatggcaGCGACTCTGCGAAATCACCTCCTGGCAGTCCAAGCAAGGATTCTGTATTCAAGAGAGTGAAGGCTGAATATTCATTTAATGGAAAGAATCCGAAGGAGCTTTCAGTCCAGCAAGGAGATGAACTTATGATTTTAGATGACAGTCGTCAATGGTGGTGTGTGCGAAATAAAAGTGGCGCTGTGGGTTTTGTTCCTAACACGATCTTTAAAAAATCAGGTTCTGGTTCGTCAAATCAAAGTCAGATATCATCAAGATCAGCACCCACTGCTGGAAGCTCACCTATCCGAGTTCCTAATGGAAATGTTCGTCGTCACGACTCATCATCATCGGAATCCTCTCTTCCCGCCGTATTTTCTACTCATTCCTCATCCTCCCAAGAAGTCCTGATATCTAAACTAAACGCAACGAATGGATCAAGTGCAGGAAACAGTTTCCAGAGTATGATCCAGAACAGAGCGAATACTTTGAAGAAAACTGAAGACACCACCGATGGGAAACCACCCCCAAAACGATTGTCAAGCGCAGACATGCTCAACGATGAACTGAAAAACAAGTTAACTTCGAAAGCTCCTTTAAGTCCAACGACCGTCCGTCCATCAACTCAAGAATCTGCAATCATCTTAAGCAAAGGTTCAACACCGTCTGATGTGCAAACATGGATGGAGGCAAAGAATTTCAGTAGAGAAGCGATGAACGCTGTGAAAAATTACAATGCTGAAGAGCTTGGCGATATGAGTAAAAACGACATCTCACGTTTAGTTGGTGACAAAGAAGGAAAGAAACTATTTTCCCAACTCACAGTTGAGAAATCTGGTGATTGTTGGCACcATATTGTGGTCCATCGTGGTGTGTCCGAACTACAGGCTGTAATGAACCGACGAAAGAACATCAGTGAATCTGATATGGCCGTGAATGGCGAGCAAGGCATCAAGAGTGCTGTGCGCGCTGCACAATCAGACACCCACGACACTTGGATTGAGAAGAAGTTAACCAAACGGCCATCGATGGAAAGTTTTGAAAGCTACAATGAATACGCGGAAGCCCGACGACAAAATCAAGAAGAATTGACCAGACAGACTTCGTTTGATCTTAAGAAGAAAGCCCCCGTTGCAGCACCCACCTCTTCAAAAGCCCCCGTGGCTGTTCCCACGTCGTCAAATAAGCCCAAACCACCTCCCCCCGCCCCAAAGCCTCGCAATTCTAGCCTATATACTCCGGCTCCCCCACCTCCTCCCGAGTATTCTGGCGCACTCCCCGCCCCTGTTGTGAATCCTGGCAGTTCAAGTAATCAAAACGTTGATGATTTACTAAGGGAACATGAACGACAACAACAGTTATTGAAGGATCAACAAAAACAACTGGCGGAACTACGCGCTCAACAACAGCAAAAGGAACAGATGCAACTCTATGAACAAGATCGAATTCGACTTGAACAACAAGTGAAGGATCAAGAAGCCATGTTGAGACTTttacagcaacagcaacagctaCCCCAAGCACAATTACAGTCCCCTCAAATCCCCATGCATCCCGGCCTCGCGGCTGGCATACCGCCACAGGGAGCCTATGTCTCCTACATACCGTATCCAATGCAAGGTGGGATACAGGCCGTTCCCATCCAAGGCGTCCAGGCCAGTCAACCTATTTATACAATCCCCCAGGTGTACGGTGCGATTCCCCCACCGGTTGGATTTCAACCAAAGTGA

Transcript

BRAKERXEIT00000029791

Protein

UniProt (Swiss-Prot top hit)

UniProt accession	Description
Q5R4H4	Epidermal growth factor receptor kinase substrate 8 OS=Pongo abelii OX=9601 GN=EPS8 PE=2 SV=2
Q12929	Epidermal growth factor receptor kinase substrate 8 OS=Homo sapiens OX=9606 GN=EPS8 PE=1 SV=1
Q08509	Epidermal growth factor receptor kinase substrate 8 OS=Mus musculus OX=10090 GN=Eps8 PE=1 SV=2

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0002377 (this species only) · gene tree & orthology
Ubiquitin family	UBD\|Other\|SH3 · all ubiquitin genes in this species

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF08416 all species →	PTB	Phosphotyrosine-binding domain	Domain	Interproscan
PF18016 all species →	SAM_3	SAM domain (Sterile alpha motif)	Domain	Interproscan
PF00018 all species →	SH3_1	SH3 domain	Domain	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR013625 all species →	Domain	Tensin/EPS8 phosphotyrosine-binding domain	Interproscan
IPR001452 all species →	Domain	SH3 domain	Interproscan
IPR036028 all species →	Homologous_superfamily	SH3-like domain superfamily	Interproscan
IPR041418 all species →	Domain	SAM domain	Interproscan
IPR013761 all species →	Homologous_superfamily	Sterile alpha motif/pointed domain superfamily	Interproscan
IPR039801 all species →	Family	Epidermal growth factor receptor kinase substrate 8-like	Interproscan
IPR011993 all species →	Homologous_superfamily	PH-like domain superfamily	Interproscan
IPR006020 all species →	Domain	PTB/PI domain	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR12287 all species →	EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8-RELATED PROTEIN	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0005515 all species →	Molecular Function	protein binding	Interproscan
GO:0003779 all species →	Molecular Function	actin binding	Interproscan
GO:0005886 all species →	Cellular Component	plasma membrane	Interproscan
GO:0007266 all species →	Biological Process	Rho protein signal transduction	Interproscan
GO:0035023 all species →	Biological Process	regulation of Rho protein signal transduction	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

KO	Enzyme	Enzyme ID	Pathway	Map ID	Source
K17277	EPS8; epidermal growth factor receptor kinase substrate 8	-	Exosome	ko04147	deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Co-expression network

Genes whose expression across the transcriptome samples of Muricea muricata tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

No co-expression network has been built for this species, so this gene has no partners to show. Networks are available for the species listed on the Network Analysis page.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Muricea muricata, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

Analysis	What it does	Status
Primer design	Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.	template found	open →
BLAST	Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.	template found	open →
Expression heatmap	Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.	no expression matrix	–
Gene family / orthogroup	Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.		open →
Gene set analysis	Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.		open →