Gene detail

Detailed information of BRAKERXEIP00000047287.1 in Muricea muricata

Genomic Location: chr5:5636551...5646389
NR annotation: XP_028403121.1, delta-1-pyrroline-5-carboxylate synthase-like isoform X2 [Dendronephthya gigantea]
Species Muricea muricata · all data for this species · gene families

Gene Structure

More details in JBrowse

Sequence

CDS

BRAKERXEIT00000047287

ATGTTTTCGATCAGAAATCAGATTTGTTCAGGCTTTCGTCTCGGCTTGAAAAATCGCTACCGTTTTAGTCAACGTGGCCTTAGTAGCACTACAAATGGCAATGGTTTGACCTCTTTTGACGACCTCTATACTGGTAAAAAGGCTGCGCTGCATCGTGTTGAATTAAAGAATAAGAAAAGAGTCATGGTTAAACTTGGTTCAGCCGTCATTACACGGGAGGATGAGTGTGGGGTAGCGCTAGGAAGATTGGCCTCTATAGTGGAACAGATCTCAGAATTACAACAGTTGGGTCATGAAATGATGTTGGTTACAAGTGGTGCTGTTGCCTTTGGCAAGCAGAGACTGCGACATGAATTACTACTTTCTCGTAGTATGAGACAGTCATTGAGACCCAGTGATCATCCCCAGGGAAAATTAATGCCAGAACTTGAACCTAGAGCTTGTGCTGCAGTTGGTCAGGGTGGATTACTTTCATTGTATGAagcaatgtttagtcagtatGGATTGACTTGTGCTCAGGTTCTCGTAACTACACCAGATTTTAAAGATCCTGAGCTGAGAACTAATTTAAGATCAACCATGGATGCATTGATCAAGATGAACTGTATCCCGATTATTAATACAAACGATGCAGTTGCTCCTCCTCCAGGTGAAGATCATGATCTAAAAGGGGTGATAAGTTTAAAAGACAATGACAGTTTGGCTGCGTTACTTGCTGTTGAGATGCAAACTGATGTCTTGGTTCTACTCTCTGATGTCGATGGCATTTATAACTCCCCTCCTGGTCGCAGTGATTCGCAACTCATCTCAACATTTCATCCGTCTGAATTGGAAAACATCACTTTTGGCGGGAAGTCCAGAGTTGGGTTGGGAGGAATGGAATCGAAGGTCAAGTCTTCCATCTGGGCTCTAGAACGTGGAACATCTGTAGTTATCGCAAATGGCGTTGGTTCTGAGTATCATGCTCTTTCTAAGATCATGTCTGGGTCGAAGATAGGAACCTTTTTCTCCCTTGCTGAACAGACCGGGCCTTCAGTGGAGGAACAAGCTATGGAAGCCAGGGATGCTGGTCGTGCATTGCAAACATTGGAACCGGAAAAGCGCGCTGACATACTCTACCGGCTGGCGGACCTTCTTGAAGAGCGAACAACCGAAATCCTCGATGCAAACGCTCGCGACCTCGAAGCTGCTGGCTCTTCGCAAGCGCTCTCTCCACCCATGTTGTCAAGACTGTCCTTAACCCCgaacaaaataaacaatctAGCTGCAGGAATTAGGCAAATTGCCGAGGGTTCGTATGAAAACATCGGACGAGTCTTGCGAAGAACGAAAGTGGCCAAGGACTTGGAGCTTGTTCAAGAGACTGTCCCTATTGGTGTCTTGATGGTGATATTTGAATCCCGTCCCGATGCCCTACCACAGGTAGCTGCCCTAGGACTGAGCACCGGCAATGGTTTGCTGTTGAAAGGCGGGAAGGAAGCGTATCACAGCAACCGGTGTTTGTTGAAAATAGTGCAAGAAGCCGTGGCTAGATACGCTCCAAGAACGGCTGTACAGCTGGTGAGCACCCGGGAGGCTGTGAGCGATCTTTTGAAACTAGATGGAATAATCGATCTTGTGATTCCTCGTGGCTCTAACGAACTTGTGCAACAAATTCAAGAAAAGAGCAAGGGGATCCCTGTGCTTGGTCATGCAGAGGGAATATGTCACGTGTTTATTGACAGAGATGCAGATCCTTCGATGGCCAATCGCGTTGTAATTGACTCGAAATGCGACTATCCAGCAGCTTGTAATGCCATGGAGACTCTGCTTATTCACAAAGATCTCGTTGGAACTCAGACATTCCAAGATATCTTAAACAACTTAAGAGACAACAAGGTCGTTGTACATCCAGGTTCGCGTTTGGCAGAGGCTTTGCCATTTGGTCCAATGCCTGCTACGTCACTACGGAAGGAATACAGTGCATTGGAATGTACGATGGAGGTTgttgatgatgttgatgatgcTATCAGTCACATCAATAAATATGGCAGTTCACACACTGATTCCATTGTTACAGAAGATGACGAAGCAGCGCAGACTTTCCTAAAGTCTGTGGACAGTGCATGCGTTTTCCACAACTGTAGCACTCGGTTTGCAGACGGTTACCGTTTTGGACTGGGTGCCGAAGTTGGAATCAGCACGGGACGAATTCACGCTCGTGGTCCTGTGGGTGTCGAGGGACTACTTACTACCAAATGGGTTCTTAAGGGAAATGGTCAAACTGTGGCAGACTTTGCCGAAGGTGGCGACTTACATTACCTGCACGAGTCTCTGCCCTTGACAGTAGAGGAAGTTGAGGGTTTTTCCGTAGAAATTGAGGATAATATAAGAGCAGATGAGAGTACTGAAAATGAAAGTCTGTATAAAGAAGACAAAATCGGTAAAGGAGGTTAA

Transcript

BRAKERXEIT00000047287

Protein

UniProt (Swiss-Prot top hit)

UniProt accession	Description
Q5R4M8	Delta-1-pyrroline-5-carboxylate synthase OS=Pongo abelii OX=9601 GN=ALDH18A1 PE=2 SV=1
P54886	Delta-1-pyrroline-5-carboxylate synthase OS=Homo sapiens OX=9606 GN=ALDH18A1 PE=1 SV=2
Q9Z110	Delta-1-pyrroline-5-carboxylate synthase OS=Mus musculus OX=10090 GN=Aldh18a1 PE=1 SV=2

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0002033 (this species only) · gene tree & orthology

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF00171 all species →	Aldedh	Aldehyde dehydrogenase family	Family	Interproscan
PF00696 all species →	AA_kinase	Amino acid kinase family	Family	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR020593 all species →	Conserved_site	Gamma-glutamyl phosphate reductase GPR, conserved site	Interproscan
IPR036393 all species →	Homologous_superfamily	Acetylglutamate kinase-like superfamily	Interproscan
IPR000965 all species →	Domain	GPR domain	Interproscan
IPR019797 all species →	Conserved_site	Glutamate 5-kinase, conserved site	Interproscan
IPR015590 all species →	Domain	Aldehyde dehydrogenase domain	Interproscan
IPR005766 all species →	Family	Delta l-pyrroline-5-carboxylate synthetase	Interproscan
IPR016162 all species →	Homologous_superfamily	Aldehyde dehydrogenase, N-terminal	Interproscan
IPR016161 all species →	Homologous_superfamily	Aldehyde/histidinol dehydrogenase	Interproscan
IPR016163 all species →	Homologous_superfamily	Aldehyde dehydrogenase, C-terminal	Interproscan
IPR001048 all species →	Domain	Aspartate/glutamate/uridylate kinase	Interproscan
IPR041744 all species →	Domain	Bifunctional delta 1-pyrroline-5-carboxylate synthetase, glutamate-5-kinase domain	Interproscan
IPR005715 all species →	Family	Glutamate 5-kinase/delta-1-pyrroline-5-carboxylate synthase	Interproscan
IPR001057 all species →	Family	Glutamate/acetylglutamate kinase	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR11063 all species →	GLUTAMATE SEMIALDEHYDE DEHYDROGENASE	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0004350 all species →	Molecular Function	glutamate-5-semialdehyde dehydrogenase activity	Interproscan
GO:0006561 all species →	Biological Process	proline biosynthetic process	Interproscan
GO:0004349 all species →	Molecular Function	glutamate 5-kinase activity	Interproscan
GO:0016491 all species →	Molecular Function	oxidoreductase activity	Interproscan
GO:0003824 all species →	Molecular Function	catalytic activity	Interproscan
GO:0005739 all species →	Cellular Component	mitochondrion	Interproscan
GO:0016620 all species →	Molecular Function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	Interproscan
GO:0005737 all species →	Cellular Component	cytoplasm	Interproscan
GO:0005524 all species →	Molecular Function	ATP binding	Interproscan
GO:0016301 all species →	Molecular Function	kinase activity	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

KO	Enzyme	Enzyme ID	Pathway	Map ID	Source
K12657	ALDH18A1, P5CS; delta-1-pyrroline-5-carboxylate synthetase	EC:2.7.2.11 EC:1.2.1.41	Arginine and proline metabolism	ko00330	deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Co-expression network

Genes whose expression across the transcriptome samples of Muricea muricata tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

No co-expression network has been built for this species, so this gene has no partners to show. Networks are available for the species listed on the Network Analysis page.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Muricea muricata, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

Analysis	What it does	Status
Primer design	Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.	template found	open →
BLAST	Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.	template found	open →
Expression heatmap	Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.	no expression matrix	–
Gene family / orthogroup	Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.		open →
Gene set analysis	Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.		open →