Genomic Location: pcla8_s007740:3034...5814
NR annotation: CAB4012494.1, DNA topoisomerase 3-alpha [Paramuricea clavata]
Species Paramuricea clavata · all data for this species · gene families
| CDS |
| PACLA_8A047676 |
| Transcript |
| rna-PACLA_8A047676 |
| Protein |
| CAB4012494.1 |
| UniProt accession | Description |
|---|---|
| Q13472 | DNA topoisomerase 3-alpha OS=Homo sapiens OX=9606 GN=TOP3A PE=1 SV=1 |
| O70157 | DNA topoisomerase 3-alpha OS=Mus musculus OX=10090 GN=Top3a PE=2 SV=1 |
| Q9NG98 | DNA topoisomerase 3-alpha OS=Drosophila melanogaster OX=7227 GN=Top3alpha PE=2 SV=2 |
| Family type | Membership / link |
|---|---|
| Orthogroup (gene family) | OG0003263 (this species only) |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF01751 all species → | Toprim | Toprim domain | Family | Interproscan |
| PF01131 all species → | Topoisom_bac | DNA topoisomerase | Family | Interproscan |
| PF06839 all species → | zf-GRF | GRF zinc finger | Domain | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR000380 all species → | Family | DNA topoisomerase, type IA | Interproscan |
| IPR010666 all species → | Domain | Zinc finger, GRF-type | Interproscan |
| IPR013825 all species → | Homologous_superfamily | DNA topoisomerase, type IA, central region, subdomain 2 | Interproscan |
| IPR003602 all species → | Domain | DNA topoisomerase, type IA, DNA-binding domain | Interproscan |
| IPR013497 all species → | Domain | DNA topoisomerase, type IA, central | Interproscan |
| IPR006171 all species → | Domain | TOPRIM domain | Interproscan |
| IPR013826 all species → | Homologous_superfamily | DNA topoisomerase, type IA, central region, subdomain 3 | Interproscan |
| IPR003601 all species → | Domain | DNA topoisomerase, type IA, domain 2 | Interproscan |
| IPR013824 all species → | Homologous_superfamily | DNA topoisomerase, type IA, central region, subdomain 1 | Interproscan |
| IPR023405 all species → | Homologous_superfamily | DNA topoisomerase, type IA, core domain | Interproscan |
| IPR034144 all species → | Domain | DNA topoisomerase 3-like, TOPRIM domain | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR11390 all species → | PROKARYOTIC DNA TOPOISOMERASE | Interproscan |
| GO term | Category | Description | Source |
|---|---|---|---|
| GO:0003677 all species → | Molecular Function | DNA binding | Interproscan |
| GO:0003916 all species → | Molecular Function | DNA topoisomerase activity | Interproscan |
| GO:0003917 all species → | Molecular Function | DNA topoisomerase type I (single strand cut, ATP-independent) activity | Interproscan |
| GO:0005634 all species → | Cellular Component | nucleus | Interproscan |
| GO:0006265 all species → | Biological Process | DNA topological change | Interproscan |
| GO:0008270 all species → | Molecular Function | zinc ion binding | Interproscan |
| KO | Enzyme | Enzyme ID | Pathway | Map ID | Source |
|---|---|---|---|---|---|
| K03165 | TOP3; DNA topoisomerase III | EC:5.6.2.1 | DNA repair and recombination proteins | ko03400 | deepkoala |
Transcript abundance of CAB4012494.1 across 21 RNA-seq samples of Paramuricea clavata. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.
| Condition | Samples | TPM > 0 | Mean TPM | Max TPM | Mean, relative to max |
|---|---|---|---|---|---|
| apical branchlet · Control at T25 | 6 | 6 | 7.25 | 14.91 | |
| apical branchlet · Temperature treatment at T0 | 6 | 6 | 9.95 | 25.70 | |
| apical branchlet · Temperature treatment at T25 | 5 | 3 | 3.47 | 8.90 | |
| apical branchlet · Control at T0 | 4 | 1 | 0.76 | 3.02 |
Source: CnidoSite RNA-seq expression matrices (PCLAV_TPM,
StringTie quantification over 21 runs), joined to SRA sample
metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped
by the descriptor carried in the expression matrix itself.
