Gene detail

Detailed information of CAB4013846.1 in Paramuricea clavata

Genomic Location: pcla8_s008291:4956...8246
NR annotation: CAB4013846.1, histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1 [Paramuricea clavata]
Species Paramuricea clavata · all data for this species · gene families

Gene Structure

More details in JBrowse

Sequence

CDS

PACLA_8A000860

ATGGCTCAAGTACTAAGTCTTCATAGTCCTGCCGGGGCAGAAGCGATGGTTTATGACTGGCCTTTACAGCATGCACACGGACGAGATGACATGCAAGAAATTATTGATACAATTCGTTGGGTTGGGAAGGATTTCCCGGAGCTACAAATCGCTATAGAAAACCATGTTTTGGATAATTATGACCGTCATTGTTTTGATAGTATGTCGAAATTGTGTGAGCGCTACAATCGAGCCGTGGATAGCGTTGTAAAGCTTTGGAAAGGGAGAGCCCCGCCGGCGTGTTTAAATCGGCGTCCTTCGCAAGAATTGCTCAGACATGTACTTTCGAAAGTGTACAATCATAGTGTAAAAGACCCTGACAAGCTCAATTTATACGAGCCATTTTCACCTGAAGTGTACGGGGAGACGTCCTTTGATCTCGTAGCACAAATGGTTAAAGCGGTTTCCTTTCAATCCGACGAAATATTTCTGGATTTGGGTAGCGGTGTTGGGCAAGTCGTACTACAAGTTGCCGCGTCTACAAACATCAAGCACTGTTTTGGTATCGAGAAAGCTGGAACCCCGGCAAAATACGCTCAAGAAATGGACAGATTATTCAGGAGATGGATGAAGTGGCATGGAAAAACCTTCAGTCCATACCACCTTGAGAAAGGAGATTTTTTATCAGAGGAAAATTGTTCTAAAATTGGTGAAGCATCTATTATATTTGTAAACAATTTCGCGTTTGGACCTACTGTCGATCATAAACTTAAACAAAGATTTTCAGCATTGAAAGATGGTACGAGGATTATATCATCGAAGCCATACTGTCCGTTGAACTTTCGAGTCACAAAACGGAACCTGTCAGACATTGGTGCTATTTTGAGGATTACTGAGTTGGCGACGATGCCTGGATCGGTCTCTTGGACGGGTAATCCGGTATCCTATTATGTACAGATGGTAGATAGCACCATGCTCGAGGAGTATTTTTCCGGCTTGAAAAAGAAGAAGGATACAGGCAAGGATGAGACGGCAAGCCTCGATGATTCGGTTAGCATTGACGAAGAATGGACGGGCAAACTTGATGAGCTTGATGACGTCTCACTTGGTGCGACCACACGACACCAATGGCATGATCTGATTGCACTGATTGAGCAACATAAGATTGAGCCGGAAAAGGACGACAAGACGGATGCATCTGATGTCAGCCTCATTAAGAAGAAGAAAAAGAAGAAACGAAAGGACAAAAAGAAAAATGCGGCAGCGAATGTGAAACGTAAATATCGTAAACACATCAAAAACAAGAAAGGGAAGCTGAATCTAGACTACGTAGCTGTTTCTGCTCTCGACAAAGCCACCAAGTCTGCACTTGGGAAGCCTTCGAGGAAACGTGCAATGCCAAAACCACCAGGAATTGATGAGTTTGTTGAAACAATGAAACAACAATATATTGCATTCTGGCAACACATGCATACACCAGAGTATTCTGAATCTGTTGTTCATGAACTTACCGAACAGCGTCGGAGAAATACGTTACTGACAAACCAAGTTGAGGATTTGGATTATCAGGTGTATAGTCTGCAACAAGAGGGGAAGAAACTTTTGGAAGACAGGATGGAAAAGATGGGGCTCGATGCTTCTAAACCTGCGGAAACTTTTGTGACTTTGCATGAGCTTGTTGAAGAACAACTAACGCTTGTTGAAGAGTGTGTGAATATGGGTAAGGAGGTTGCAATGCTCGAGAATTCTTGTGGTGTTACAAATGGCGAGGAAGTACATGACACTTGTAAGATTGAAAACGAGGTGCTCTTACATGAGCTATATGTGCCAGATAACTTTCGCAAGGGTTTGCTCAATGAAGTCACCATGCAAAAGAAGCGGAAACGAGACTTGTTAGATCAGATCAAAGAAATGGAGTGTAAGACAAGGTCACTTGAGACTGGAAATGGGTCGCCAAGGAAGAGAACATTAATGGATAATTGTGGACAATATGAGGATATGGAGGTTGATGTGGGGATGCCACAGGTCTTTACTAGTATTCCAAAAGAGAGTTTGGGTGAACAAAACAAAGACAGTTCAAAGTTGTCGTTAATGGAGCCTGCCATGTTTAACCCATATAATCCAACATCATGTGTGCCGGTGGCTGCGCCTGACCCGGTCGGTGAATACAGTACCAGTAACCTAGCCCCAGATCAAGTGCTTGCATACACTTTTCATAACCTTCCCAGCCAAGGACGGCCGAGTAGTTCCACCCATGTTGAACAAACACCAAGTATGCTCCCTTCACTCTTTGTGTCGAGCCCGTCAACTAGGTTATCTTCGCTGTTTCCAGCCACCCTTGGTGAGCCAAGGCATTCTGCCAAGAATTTGCAAAAGATTCACAAGTTGCTTTGCGAGAATTCAGACTCGCCTGAGAAAAATGCAAACTCTTCTGAGCCGAAGACAAAGTCAAATTTCAGCATTGCTCATCTTACAGGAATTTCTGATCAGTCCTCGATTGGTAAACAACTTGTTGACTTGGATAGCACGTCTGATGTTGAAAGCAAGAAGACGCCAGAAGGGCCACAGAGATCATCGCCTCAATCCTCTGGTCACAAAGTGAAATCCCAAGCTGCAAGCAGTCCCAGTGCATGTCGTATCAAAGGAGAGAGCCCTTCAAGTTGTACTCAAGTTGGCTTACCAAAACCACTGCTGTTAAACGGTGTGAAAGATTTACCAAGTCATATTAAGAAAGCTATCAATCCCCCCGGGGGTGGGTCCACGGACTGTGTGGTCAACTTGGGACATGTTCCTAGAACATCCACTTCTCGTTTTGTAGACATGACTAGTGCTCATGATTCAACCAATCACAGCAAAGCTGTTTACTCTAGTCCATGTTTGAAATCAAACATTCAACAAACTTTATCAACAACAAATAGTTGTGTCCGAGAACCTGTTATCACCATATCCTATCCACCTAACAAAGAGCAAACTCATGTATCAAGTTTGTTGAACTCAAATCCCCACACTAACCCCATGGGGATTACCAAGACAGTAAGTGCAGATTGCCTCGGCAAGGAGCAAAGAGGACAACCTGGTGATTCGACTCAGCGGTTTATCCATCCTGCCCGACCAAACACGATAGTCTACAGTAAAAGTGAACCACCCATCAGAAACATAGTTTTAAAGAATGACTCAGTGCCTTATTTCAATAACAATGATGCAGTGCCCAGATTTTCCAGCAAGGTGCTGAGACCGAGCGAAAGTGCAAAAATCTTGAACAGTATGTATATGATGTCACAGTATCATGGTGATGGACGACATTCTAGTTGA

Transcript

rna-PACLA_8A000860

ATGGCTCAAGTACTAAGTCTTCATAGTCCTGCCGGGGCAGAAGCGATGGTTTATGACTGGCCTTTACAGCATGCACACGGACGAGATGACATGCAAGAAATTATTGATACAATTCGTTGGGTTGGGAAGGATTTCCCGGAGCTACAAATCGCTATAGAAAACCATGTTTTGGATAATTATGACCGTCATTGTTTTGATAGTATGTCGAAATTGTGTGAGCGCTACAATCGAGCCGTGGATAGCGTTGTAAAGCTTTGGAAAGGGAGAGCCCCGCCGGCGTGTTTAAATCGGCGTCCTTCGCAAGAATTGCTCAGACATGTACTTTCGAAAGTGTACAATCATAGTGTAAAAGACCCTGACAAGCTCAATTTATACGAGCCATTTTCACCTGAAGTGTACGGGGAGACGTCCTTTGATCTCGTAGCACAAATGGTTAAAGCGGTTTCCTTTCAATCCGACGAAATATTTCTGGATTTGGGTAGCGGTGTTGGGCAAGTCGTACTACAAGTTGCCGCGTCTACAAACATCAAGCACTGTTTTGGTATCGAGAAAGCTGGAACCCCGGCAAAATACGCTCAAGAAATGGACAGATTATTCAGGAGATGGATGAAGTGGCATGGAAAAACCTTCAGTCCATACCACCTTGAGAAAGGAGATTTTTTATCAGAGGAAAATTGTTCTAAAATTGGTGAAGCATCtattatatttgtaaacaatTTCGCGTTTGGACCTACTGTCGATCATAAACTTAAACAAAGATTTTCAGCATTGAAAGATGGTACGAGGATTATATCATCGAAGCCATACTGTCCGTTGAACTTTCGAGTCACAAAACGGAACCTGTCAGACATTGGTGCTATTTTGAGGATTACTGAGTTGGCGACGATGCCTGGATCGGTCTCTTGGACGGGTAATCCGGTATCCTATTATGTACAGATGGTAGATAGCACCATGCTCGAGGAGTATTTTTCCGGCTTGAAAAAGAAGAAGGATACAGGCAAGGATGAGACGGCAAGCCTCGATGATTCGGTTAGCATTGACGAAGAATGGACGGGCAAACTTGATGAGCTTGATGACGTCTCACTTGGTGCGACCACACGACACCAATGGCATGATCTGATTGCACTGATTGAGCAACATAAGATTGAGCCGGAAAAGGACGACAAGACGGATGCATCTGATGTCAGCCTCATtaagaagaagaaaaagaagaaacgAAAGGACAAAAAGAAAAATGCGGCAGCGAATGTGAAACGTAAATATCGTAAACACATCAAAAACAAGAAAGGGAAGCTGAATCTAGACTACGTAGCTGTTTCTGCTCTCGACAAAGCCACCAAGTCTGCACTTGGGAAGCCTTCGAGGAAACGTGCAATGCCAAAACCACCAGGAATTGATGAGTTTGTTGAAACAATGAAACAACAATATATTGCATTCTGGCAACACATGCATACACCAGAGTATTCTGAATCTGTTGTTCATGAACTTACCGAACAGCGTCGGAGAAATACGTTACTGACAAACCAAGTTGAGGATTTGGATTATCAGGTGTATAGTCTGCAACAAGAGGGGAAGAAACTTTTGGAAGACAGGATGGAAAAGATGGGGCTCGATGCTTCTAAACCTGCGGAAACTTTTGTGACTTTGCATGAGCTTGTTGAAGAACAACTAACGCTTGTTGAAGAGTGTGTGAATATGGGTAAGGAGGTTGCAATGCTCGAGAATTCTTGTGGTGTTACAAATGGCGAGGAAGTACATGACACTTGTAAGATTGAAAACGAGGTGCTCTTACATGAGCTATATGTGCCAGATAACTTTCGCAAGGGTTTGCTCAATGAAGTCACCATGCAAAAGAAGCGGAAACGAGACTTGTTAGATCAGATCAAAGAAATGGAGTGTAAGACAAGGTCACTTGAGACTGGAAATGGGTCGCCAAGGAAGAGAACATTAATGGATAATTGTGGACAATATGAGGATATGGAGGTTGATGTGGGGATGCCACAGGTCTttactagtattccaaaagAGAGTTTGGGTGAACAAAACAAAGACAGTTCAAAGTTGTCGTTAATGGAGCCTGCCATGTTTAACCCATATAATCCAACATCATGTGTGCCGGTGGCTGCGCCTGACCCGGTCGGTGAATACAGTACCAGTAACCTAGCCCCAGATCAAGTGCTTGCATACACTTTTCATAACCTTCCCAGCCAAGGACGGCCGAGTAGTTCCACCCATGTTGAACAAACACCAAGTATGCTCCCTTCACTCTTTGTGTCGAGCCCGTCAACTAGGTTATCTTCGCTGTTTCCAGCCACCCTTGGTGAGCCAAGGCATTCTGCCAAGAATTTGCAAAAGATTCACAAGTTGCTTTGCGAGAATTCAGACTCGCCTGAGAAAAATGCAAACTCTTCTGAGCCGAAGACAAAGTCAAATTTCAGCATTGCTCATCTTACAGGAATTTCTGATCAGTCCTCGATTGGTAAACAACTTGTTGACTTGGATAGCACGTCTGATGTTGAAAGCAAGAAGACGCCAGAAGGGCCACAGAGATCATCGCCTCAATCCTCTGGTCACAAAGTGAAATCCCAAGCTGCAAGCAGTCCCAGTGCATGTCGTATCAAAGGAGAGAGCCCTTCAAGTTGTACTCAAGTTGGCTTACCAAAACCACTGCTGTTAAACGGTGTGAAAGATTTACCAAGTCATATTAAGAAAGCTATCAATCCCCCCGGGGGTGGGTCCACGGACTGTGTGGTCAACTTGGGACATGTTCCTAGAACATCCACTTCTCGTTTTGTAGACATGACTAGTGCTCATGattcaaccaatcacagcaaAGCTGTTTACTCTAGTCCATGTTTGAAATCAAACATTCAACAAACtttatcaacaacaaatagTTGTGTCCGAGAACCTGTTATCACCATATCCTATCCACCTAACAAAGAGCAAACTCATGTATCAAGTTTGTTGAACTCAAATCCCCACACTAACCCCATGGGGATTACCAAGACAGTAAGTGCAGATTGCCTCGGCAAGGAGCAAAGAGGACAACCTGGTGATTCGACTCAGCGGTTTATCCATCCTGCCCGACCAAACACGATAGTCTACAGTAAAAGTGAACCACCCATCAGAAACATAGTTTTAAAGAATGACTCAGTGCCTTATTTCAATAACAATGATGCAGTGCCCAGATTTTCCAGCAAGGTGCTGAGACCGAGCGAAAGTGCAAAAATCTTGAACAGTATGTATATGATGTCACAGTATCATGGTGATGGACGACATTCTAGTTGA

Protein

UniProt (Swiss-Prot top hit)

UniProt accession	Description
Q8TEK3	Histone-lysine N-methyltransferase, H3 lysine-79 specific OS=Homo sapiens OX=9606 GN=DOT1L PE=1 SV=3
Q8INR6	Histone-lysine N-methyltransferase, H3 lysine-79 specific OS=Drosophila melanogaster OX=7227 GN=gpp PE=1 SV=2
Q6AW06	Histone-lysine N-methyltransferase, H3 lysine-79 specific OS=Caenorhabditis elegans OX=6239 GN=dot-1.1 PE=1 SV=2

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0005416 (this species only)

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF08123 all species →	DOT1	Histone methylation protein DOT1	Domain	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR029063 all species →	Homologous_superfamily	S-adenosyl-L-methionine-dependent methyltransferase superfamily	Interproscan
IPR025789 all species →	Domain	Histone-lysine N-methyltransferase DOT1 domain	Interproscan
IPR030445 all species →	Family	Histone H3-K79 methyltransferase	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR21451 all species →	HISTONE H3 METHYLTRANSFERASE	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0031151 all species →	Molecular Function	histone H3K79 methyltransferase activity	Interproscan
GO:0000077 all species →	Biological Process	DNA damage checkpoint signaling	Interproscan
GO:0005634 all species →	Cellular Component	nucleus	Interproscan
GO:0006281 all species →	Biological Process	DNA repair	Interproscan
GO:0051726 all species →	Biological Process	regulation of cell cycle	Interproscan
GO:2000677 all species →	Biological Process	regulation of transcription regulatory region DNA binding	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

KO	Enzyme	Enzyme ID	Pathway	Map ID	Source
K11427	DOT1L, DOT1; [histone H3]-lysine79 N-trimethyltransferase	EC:2.1.1.360	Chromosome and associated proteins	ko03036	deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Expression pattern (RNA-seq)

Transcript abundance of CAB4013846.1 across 21 RNA-seq samples of Paramuricea clavata. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.

21Samples

19TPM > 0

4Conditions

22.4Max TPM

8.6Mean TPM

By condition

Condition	Samples	TPM > 0	Mean TPM	Max TPM
apical branchlet · Control at T25	6	6	10.55	22.44
apical branchlet · Temperature treatment at T0	6	5	7.38	19.43
apical branchlet · Temperature treatment at T25	5	4	7.68	15.40
apical branchlet · Control at T0	4	4	8.88	12.35

Per sample · hover a bar for the full sample record · show / hide the sample table

SRA run	Condition	Tissue	Developmental stage	Treatment	Study	TPM
SRR19977433	apical branchlet · Control at T25	apical branchlet	not recorded	Control at T25	SRP384900	22.44
SRR19977444	apical branchlet · Control at T25	apical branchlet	not recorded	Control at T25	SRP384900	11.80
SRR19977439	apical branchlet · Control at T25	apical branchlet	not recorded	Control at T25	SRP384900	9.88
SRR19977455	apical branchlet · Control at T25	apical branchlet	not recorded	Control at T25	SRP384900	7.82
SRR19977441	apical branchlet · Control at T25	apical branchlet	not recorded	Control at T25	SRP384900	7.07
SRR19977440	apical branchlet · Control at T25	apical branchlet	not recorded	Control at T25	SRP384900	4.26
SRR19977428	apical branchlet · Temperature treatment at T0	apical branchlet	not recorded	Temperature treatment at T0	SRP384900	19.43
SRR19977436	apical branchlet · Temperature treatment at T0	apical branchlet	not recorded	Temperature treatment at T0	SRP384900	9.98
SRR19977427	apical branchlet · Temperature treatment at T0	apical branchlet	not recorded	Temperature treatment at T0	SRP384900	7.16
SRR19977437	apical branchlet · Temperature treatment at T0	apical branchlet	not recorded	Temperature treatment at T0	SRP384900	4.71
SRR19977438	apical branchlet · Temperature treatment at T0	apical branchlet	not recorded	Temperature treatment at T0	SRP384900	3.00
SRR19977426	apical branchlet · Temperature treatment at T0	apical branchlet	not recorded	Temperature treatment at T0	SRP384900	0.00
SRR19977432	apical branchlet · Temperature treatment at T25	apical branchlet	not recorded	Temperature treatment at T25	SRP384900	15.40
SRR19977463	apical branchlet · Temperature treatment at T25	apical branchlet	not recorded	Temperature treatment at T25	SRP384900	14.72
SRR19977435	apical branchlet · Temperature treatment at T25	apical branchlet	not recorded	Temperature treatment at T25	SRP384900	5.66
SRR19977425	apical branchlet · Temperature treatment at T25	apical branchlet	not recorded	Temperature treatment at T25	SRP384900	2.61
SRR19977434	apical branchlet · Temperature treatment at T25	apical branchlet	not recorded	Temperature treatment at T25	SRP384900	0.00
SRR19977446	apical branchlet · Control at T0	apical branchlet	not recorded	Control at T0	SRP384900	12.35
SRR19977445	apical branchlet · Control at T0	apical branchlet	not recorded	Control at T0	SRP384900	12.11
SRR19977442	apical branchlet · Control at T0	apical branchlet	not recorded	Control at T0	SRP384900	6.50
SRR19977443	apical branchlet · Control at T0	apical branchlet	not recorded	Control at T0	SRP384900	4.56

Source: CnidoSite RNA-seq expression matrices (PCLAV_TPM, StringTie quantification over 21 runs), joined to SRA sample metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped by the descriptor carried in the expression matrix itself.