Genomic Location: :...
NR annotation: PFX15855.1, C-1-tetrahydrofolate synthase, cytoplasmic, partial [Stylophora pistillata]
| CDS | ||||
| ENSAVKT00000014627 | ||||
| Transcript |
| ENSAVKT00000014627 |
| Protein |
| ENSAVKP00000013551.1 |
| Uniprot term | Description | |||
|---|---|---|---|---|
| Q922D8 | C-1-tetrahydrofolate synthase, cytoplasmic OS=Mus musculus OX=10090 GN=Mthfd1 PE=1 SV=4 | |||
| P11586 | C-1-tetrahydrofolate synthase, cytoplasmic OS=Homo sapiens OX=9606 GN=MTHFD1 PE=1 SV=4 | |||
| Q5R8P0 | C-1-tetrahydrofolate synthase, cytoplasmic OS=Pongo abelii OX=9601 GN=MTHFD1 PE=2 SV=3 |
| Gene family | Subfamily |
|---|---|
| Ubiquitin Family | E3|E3 activity RING|RING |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF00763 | THF_DHG_CYH | Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain | Domain | Interproscan |
| PF00630 | Filamin | Filamin/ABP280 repeat | Domain | Interproscan |
| PF01268 | FTHFS | Formate--tetrahydrofolate ligase | Family | Interproscan |
| PF01436 | NHL | NHL repeat | Repeat | Interproscan |
| PF00643 | zf-B_box | B-box zinc finger | Domain | Interproscan |
| PF00097 | zf-C3HC4 | Zinc finger, C3HC4 type (RING finger) | Domain | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR001258 | Repeat | NHL repeat | Interproscan |
| IPR013783 | Homologous_superfamily | Immunoglobulin-like fold | Interproscan |
| IPR000315 | Domain | B-box-type zinc finger | Interproscan |
| IPR020630 | Domain | Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain | Interproscan |
| IPR050952 | Family | Tripartite Motif and NHL Repeat Containing E3 Ligases | Interproscan |
| IPR001841 | Domain | Zinc finger, RING-type | Interproscan |
| IPR046346 | Homologous_superfamily | Aminoacid dehydrogenase-like, N-terminal domain superfamily | Interproscan |
| IPR013083 | Homologous_superfamily | Zinc finger, RING/FYVE/PHD-type | Interproscan |
| IPR017868 | Repeat | Filamin/ABP280 repeat-like | Interproscan |
| IPR011042 | Homologous_superfamily | Six-bladed beta-propeller, TolB-like | Interproscan |
| IPR000559 | Family | Formate-tetrahydrofolate ligase, FTHFS | Interproscan |
| IPR014756 | Homologous_superfamily | Immunoglobulin E-set | Interproscan |
| IPR001298 | Repeat | Filamin/ABP280 repeat | Interproscan |
| IPR027417 | Homologous_superfamily | P-loop containing nucleoside triphosphate hydrolase | Interproscan |
| IPR018957 | Domain | Zinc finger, C3HC4 RING-type | Interproscan |
| IPR017907 | Conserved_site | Zinc finger, RING-type, conserved site | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR24104 | E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED | Interproscan |
| GO terms | Category | Description | Source |
|---|---|---|---|
| GO:0005515 | Molecular Function | protein binding | Interproscan |
| GO:0008270 | Molecular Function | zinc ion binding | Interproscan |
| GO:0004488 | Molecular Function | methylenetetrahydrofolate dehydrogenase (NADP+) activity | Interproscan |
| GO:0000209 | Biological Process | protein polyubiquitination | Interproscan |
| GO:0043161 | Biological Process | proteasome-mediated ubiquitin-dependent protein catabolic process | Interproscan |
| GO:0061630 | Molecular Function | ubiquitin protein ligase activity | Interproscan |
| GO:0004329 | Molecular Function | formate-tetrahydrofolate ligase activity | Interproscan |
| GO:0005524 | Molecular Function | ATP binding | Interproscan |
| GO:0046872 | Molecular Function | metal ion binding | Interproscan |