Genomic Location: JASJOG010000002.1:2569035...2589960
NR annotation: CAB3998957.1, breast cancer type 1 susceptibility isoform X1, partial [Paramuricea clavata]
Species Heliopora coerulea · all data for this species · gene families
| CDS |
| ENSBQFT00000002837 |
| Protein |
| ENSBQFP00000002525.1 |
| UniProt accession | Description |
|---|---|
| Q864U1 | Breast cancer type 1 susceptibility protein homolog OS=Bos taurus OX=9913 GN=BRCA1 PE=1 SV=1 |
| Q6J6I8 | Breast cancer type 1 susceptibility protein homolog OS=Gorilla gorilla gorilla OX=9595 GN=BRCA1 PE=3 SV=1 |
| P38398 | Breast cancer type 1 susceptibility protein OS=Homo sapiens OX=9606 GN=BRCA1 PE=1 SV=2 |
| Family type | Membership / link |
|---|---|
| Orthogroup (gene family) | OG0005048 (this species only) · gene tree & orthology |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF00533 all species → | BRCT | BRCA1 C Terminus (BRCT) domain | Family | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR036420 all species → | Homologous_superfamily | BRCT domain superfamily | Interproscan |
| IPR001357 all species → | Domain | BRCT domain | Interproscan |
| IPR031099 all species → | Family | BRCA1-associated | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR13763 all species → | BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN BRCA1 | Interproscan |
| GO term | Category | Description | Source |
|---|---|---|---|
| GO:0000724 all species → | Biological Process | double-strand break repair via homologous recombination | Interproscan |
| GO:0004842 all species → | Molecular Function | ubiquitin-protein transferase activity | Interproscan |
| GO:0005886 all species → | Cellular Component | plasma membrane | Interproscan |
| GO:0006281 all species → | Biological Process | DNA repair | Interproscan |
| GO:0006974 all species → | Biological Process | DNA damage response | Interproscan |
| GO:0031436 all species → | Cellular Component | BRCA1-BARD1 complex | Interproscan |
| GO:0035066 all species → | Biological Process | obsolete positive regulation of histone acetylation | Interproscan |
| GO:0035067 all species → | Biological Process | obsolete negative regulation of histone acetylation | Interproscan |
| GO:0045717 all species → | Biological Process | negative regulation of fatty acid biosynthetic process | Interproscan |
| GO:0045944 all species → | Biological Process | positive regulation of transcription by RNA polymerase II | Interproscan |
| GO:0070531 all species → | Cellular Component | BRCA1-A complex | Interproscan |
ENSBQFP00000002525.1.Transcript abundance of ENSBQFP00000002525.1 across 37 RNA-seq samples of Heliopora coerulea. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.
| Condition | Samples | TPM > 0 | Mean TPM | Max TPM | Mean, relative to max |
|---|---|---|---|---|---|
| Whole coral | 17 | 15 | 24.06 | 49.08 | |
| polyp and skeleton · 31C, 3week | 6 | 6 | 8.45 | 17.44 | |
| polyp and skeleton · 28C, 3week | 6 | 4 | 3.96 | 7.88 | |
| polyp and skeleton · 26C, 3week | 4 | 2 | 3.88 | 8.05 | |
| polyp and skeleton · 28C, 24hr | 2 | 2 | 5.78 | 6.33 | |
| polyp and skeleton · 31C, 24hr | 2 | 1 | 4.97 | 9.94 |
| SRA run | Condition | Tissue | Developmental stage | Treatment | Study | TPM |
|---|---|---|---|---|---|---|
| ERR6178387 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 49.08 |
| ERR6178389 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 37.69 |
| ERR6178779 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 37.56 |
| ERR6178776 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 33.34 |
| ERR6178782 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 29.71 |
| ERR6178773 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 28.54 |
| ERR6178388 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 26.19 |
| ERR6178781 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 26.02 |
| ERR6178770 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 24.31 |
| ERR6178772 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 23.95 |
| ERR6178780 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 22.43 |
| ERR6178783 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 19.44 |
| ERR6178778 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 17.18 |
| ERR6178771 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 17.13 |
| ERR6178774 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 16.43 |
| ERR6178775 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 0.00 |
| ERR6178777 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 0.00 |
| SRR12578066 | polyp and skeleton · 31C, 3week | polyp and skeleton | not recorded | 31C, 3week | SRP115860 | 17.44 |
| SRR12587804 | polyp and skeleton · 31C, 3week | polyp and skeleton | not recorded | 31C, 3week | SRP115860 | 10.42 |
| SRR12578068 | polyp and skeleton · 31C, 3week | polyp and skeleton | not recorded | 31C, 3week | SRP115860 | 8.49 |
| SRR12578065 | polyp and skeleton · 31C, 3week | polyp and skeleton | not recorded | 31C, 3week | SRP115860 | 6.97 |
| SRR12587800 | polyp and skeleton · 31C, 3week | polyp and skeleton | not recorded | 31C, 3week | SRP115860 | 5.61 |
| SRR12587799 | polyp and skeleton · 31C, 3week | polyp and skeleton | not recorded | 31C, 3week | SRP115860 | 1.79 |
| SRR12587802 | polyp and skeleton · 28C, 3week | polyp and skeleton | not recorded | 28C, 3week | SRP115860 | 7.88 |
| SRR12587807 | polyp and skeleton · 28C, 3week | polyp and skeleton | not recorded | 28C, 3week | SRP115860 | 6.87 |
| SRR12587808 | polyp and skeleton · 28C, 3week | polyp and skeleton | not recorded | 28C, 3week | SRP115860 | 6.36 |
| SRR12587803 | polyp and skeleton · 28C, 3week | polyp and skeleton | not recorded | 28C, 3week | SRP115860 | 2.65 |
| SRR12578067 | polyp and skeleton · 28C, 3week | polyp and skeleton | not recorded | 28C, 3week | SRP115860 | 0.00 |
| SRR5949849 | polyp and skeleton · 28C, 3week | polyp and skeleton | not recorded | 28C, 3week | SRP115860 | 0.00 |
| SRR12587805 | polyp and skeleton · 26C, 3week | polyp and skeleton | not recorded | 26C, 3week | SRP115860 | 8.05 |
| SRR12587798 | polyp and skeleton · 26C, 3week | polyp and skeleton | not recorded | 26C, 3week | SRP115860 | 7.49 |
| SRR12587801 | polyp and skeleton · 26C, 3week | polyp and skeleton | not recorded | 26C, 3week | SRP115860 | 0.00 |
| SRR12587806 | polyp and skeleton · 26C, 3week | polyp and skeleton | not recorded | 26C, 3week | SRP115860 | 0.00 |
| SRR5949850 | polyp and skeleton · 28C, 24hr | polyp and skeleton | not recorded | 28C, 24hr | SRP115860 | 6.33 |
| SRR12578063 | polyp and skeleton · 28C, 24hr | polyp and skeleton | not recorded | 28C, 24hr | SRP115860 | 5.24 |
| SRR12578064 | polyp and skeleton · 31C, 24hr | polyp and skeleton | not recorded | 31C, 24hr | SRP115860 | 9.94 |
| SRR5949848 | polyp and skeleton · 31C, 24hr | polyp and skeleton | not recorded | 31C, 24hr | SRP115860 | 0.00 |
Source: CnidoSite RNA-seq expression matrices (HCOER_TPM,
StringTie quantification over 37 runs), joined to SRA sample
metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped
by the descriptor carried in the expression matrix itself.
Genes whose expression across the transcriptome samples of Heliopora coerulea tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.
| Direction | Partners | Most correlated partner | PCC |
|---|---|---|---|
| Positively correlated | 46 | ENSBQFP00000001468 | 0.932799701068384 |
| Negatively correlated | 3 | ENSBQFP00000002522 | -0.74155997179723 |
Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list. Partner counts were matched on ENSBQFP00000002525, the spelling this network uses.
Whether this gene can be visualised in the single-cell atlases of Heliopora coerulea, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.
No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.
Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.
No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.
Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.
| Analysis | What it does | Status | |
|---|---|---|---|
| Primer design | Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed. | template found | open → |
| BLAST | Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start. | template found | open → |
| Expression heatmap | Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it. | ready | open → |
| Gene family / orthogroup | Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue. | open → | |
| Gene set analysis | Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it. | open → |
