Detailed information of ENSBQFP00000005902.1 in Heliopora coerulea

Genomic Location: JASJOG010000007.1:448041...451008
NR annotation: CAB3996075.1, SUMO-activating enzyme subunit 2 [Paramuricea clavata]
Species Heliopora coerulea · all data for this species · gene families


 Gene Structure
More details in JBrowse  Sequence
CDS
Protein
 UniProt (Swiss-Prot top hit)
UniProt accessionDescription
Q28GH3SUMO-activating enzyme subunit 2 OS=Xenopus tropicalis OX=8364 GN=uba2 PE=2 SV=1
Q7SXG4SUMO-activating enzyme subunit 2 OS=Danio rerio OX=7955 GN=uba2 PE=1 SV=2
Q9UBT2SUMO-activating enzyme subunit 2 OS=Homo sapiens OX=9606 GN=UBA2 PE=1 SV=2
 Gene family
Family typeMembership / link
Orthogroup (gene family)OG0005260 (this species only) · gene tree & orthology
Ubiquitin familyE1|ThiF|ThiF · all ubiquitin genes in this species

 Pfam domain
Pfam accessionPfam nameDescriptionTypeSource
PF00899
all species →		ThiFThiF familyDomainInterproscan
PF10585
all species →		UBA_E1_SCCHUbiquitin-activating enzyme, SCCH domainDomainInterproscan
PF14732
all species →		UAE_UbLUbiquitin/SUMO-activating enzyme ubiquitin-like domainDomainInterproscan

 InterPro
InterPro termTypeDescriptionSource
IPR045886
all species →		FamilyThiF/MoeB/HesA familyInterproscan
IPR000594
all species →		DomainTHIF-type NAD/FAD binding foldInterproscan
IPR019572
all species →		DomainUbiquitin-activating enzyme, SCCH domainInterproscan
IPR028077
all species →		DomainUbiquitin/SUMO-activating enzyme ubiquitin-like domainInterproscan
IPR033127
all species →		Active_siteUbiquitin-activating enzyme E1, Cys active siteInterproscan
IPR035985
all species →		Homologous_superfamilyUbiquitin-activating enzymeInterproscan
IPR042449
all species →		Homologous_superfamilyUbiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1Interproscan
IPR023318
all species →		Homologous_superfamilyUbiquitin activating enzyme, alpha domain superfamilyInterproscan

 PANTHER
PANTHER termDescriptionSource
PTHR10953
all species →		UBIQUITIN-ACTIVATING ENZYME E1Interproscan

 Gene Ontology
GO termCategoryDescriptionSource
GO:0005737
all species →		Cellular ComponentcytoplasmInterproscan
GO:0016925
all species →		Biological Processprotein sumoylationInterproscan
GO:0019948
all species →		Molecular FunctionSUMO activating enzyme activityInterproscan
GO:0031510
all species →		Cellular ComponentSUMO activating enzyme complexInterproscan
GO:0032446
all species →		Biological Processprotein modification by small protein conjugationInterproscan
GO:0008641
all species →		Molecular Functionubiquitin-like modifier activating enzyme activityInterproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.
 KEGG pathway
KOEnzymeEnzyme IDPathwayMap IDSource
K10685UBLE1B, SAE2, UBA2; ubiquitin-like 1-activating enzyme E1 BEC:6.2.1.45
Ubiquitin systemko04121deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Expression pattern (RNA-seq)

Transcript abundance of ENSBQFP00000005902.1 across 37 RNA-seq samples of Heliopora coerulea. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.

37Samples
33TPM > 0
6Conditions
52.6Max TPM
17.3Mean TPM

By condition

ConditionSamplesTPM > 0 Mean TPMMax TPMMean, relative to max
Whole coral 17 17 19.77 36.11
polyp and skeleton · 31C, 3week 6 6 15.82 22.89
polyp and skeleton · 28C, 3week 6 4 11.46 27.05
polyp and skeleton · 26C, 3week 4 3 21.81 52.61
polyp and skeleton · 28C, 24hr 2 2 21.25 23.57
polyp and skeleton · 31C, 24hr 2 1 6.10 12.20

Per sample · hover a bar for the full sample record

Show the sample table (37 samples)
SRA runConditionTissueDevelopmental stage TreatmentStudyTPM
ERR6178775 Whole coral Whole coral not recorded not recorded ERP120267 36.11
ERR6178388 Whole coral Whole coral not recorded not recorded ERP120267 23.76
ERR6178771 Whole coral Whole coral not recorded not recorded ERP120267 22.07
ERR6178783 Whole coral Whole coral not recorded not recorded ERP120267 21.89
ERR6178773 Whole coral Whole coral not recorded not recorded ERP120267 20.46
ERR6178772 Whole coral Whole coral not recorded not recorded ERP120267 20.38
ERR6178780 Whole coral Whole coral not recorded not recorded ERP120267 19.94
ERR6178770 Whole coral Whole coral not recorded not recorded ERP120267 19.39
ERR6178778 Whole coral Whole coral not recorded not recorded ERP120267 18.70
ERR6178781 Whole coral Whole coral not recorded not recorded ERP120267 18.30
ERR6178776 Whole coral Whole coral not recorded not recorded ERP120267 18.22
ERR6178389 Whole coral Whole coral not recorded not recorded ERP120267 17.94
ERR6178777 Whole coral Whole coral not recorded not recorded ERP120267 17.81
ERR6178774 Whole coral Whole coral not recorded not recorded ERP120267 17.05
ERR6178779 Whole coral Whole coral not recorded not recorded ERP120267 16.84
ERR6178387 Whole coral Whole coral not recorded not recorded ERP120267 14.23
ERR6178782 Whole coral Whole coral not recorded not recorded ERP120267 13.05
SRR12587804 polyp and skeleton · 31C, 3week polyp and skeleton not recorded 31C, 3week SRP115860 22.89
SRR12587800 polyp and skeleton · 31C, 3week polyp and skeleton not recorded 31C, 3week SRP115860 17.85
SRR12578065 polyp and skeleton · 31C, 3week polyp and skeleton not recorded 31C, 3week SRP115860 16.62
SRR12578066 polyp and skeleton · 31C, 3week polyp and skeleton not recorded 31C, 3week SRP115860 15.33
SRR12587799 polyp and skeleton · 31C, 3week polyp and skeleton not recorded 31C, 3week SRP115860 13.52
SRR12578068 polyp and skeleton · 31C, 3week polyp and skeleton not recorded 31C, 3week SRP115860 8.71
SRR12587802 polyp and skeleton · 28C, 3week polyp and skeleton not recorded 28C, 3week SRP115860 27.05
SRR12587808 polyp and skeleton · 28C, 3week polyp and skeleton not recorded 28C, 3week SRP115860 17.84
SRR12587807 polyp and skeleton · 28C, 3week polyp and skeleton not recorded 28C, 3week SRP115860 13.74
SRR12587803 polyp and skeleton · 28C, 3week polyp and skeleton not recorded 28C, 3week SRP115860 10.12
SRR12578067 polyp and skeleton · 28C, 3week polyp and skeleton not recorded 28C, 3week SRP115860 0.00
SRR5949849 polyp and skeleton · 28C, 3week polyp and skeleton not recorded 28C, 3week SRP115860 0.00
SRR12587806 polyp and skeleton · 26C, 3week polyp and skeleton not recorded 26C, 3week SRP115860 52.61
SRR12587798 polyp and skeleton · 26C, 3week polyp and skeleton not recorded 26C, 3week SRP115860 18.78
SRR12587805 polyp and skeleton · 26C, 3week polyp and skeleton not recorded 26C, 3week SRP115860 15.86
SRR12587801 polyp and skeleton · 26C, 3week polyp and skeleton not recorded 26C, 3week SRP115860 0.00
SRR12578063 polyp and skeleton · 28C, 24hr polyp and skeleton not recorded 28C, 24hr SRP115860 23.57
SRR5949850 polyp and skeleton · 28C, 24hr polyp and skeleton not recorded 28C, 24hr SRP115860 18.93
SRR12578064 polyp and skeleton · 31C, 24hr polyp and skeleton not recorded 31C, 24hr SRP115860 12.20
SRR5949848 polyp and skeleton · 31C, 24hr polyp and skeleton not recorded 31C, 24hr SRP115860 0.00

Source: CnidoSite RNA-seq expression matrices (HCOER_TPM, StringTie quantification over 37 runs), joined to SRA sample metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped by the descriptor carried in the expression matrix itself.

Co-expression network

Genes whose expression across the transcriptome samples of Heliopora coerulea tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

DirectionPartnersMost correlated partnerPCC
Positively correlated40ENSBQFP000000225670.900651600049556
Negatively correlated6ENSBQFP00000026255-0.703135324854733

Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list. Partner counts were matched on ENSBQFP00000005902, the spelling this network uses.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Heliopora coerulea, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

AnalysisWhat it doesStatus
Primer designDesign PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.template foundopen →
BLASTSearch this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.template foundopen →
Expression heatmapDraw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.readyopen →
Gene family / orthogroupLook this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.open →
Gene set analysisStart a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.open →
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