Genomic Location: JASJOG010000013.1:251946...310641
NR annotation: XP_028405372.1, dihydropyrimidine dehydrogenase [NADP(+)]-like [Dendronephthya gigantea]
Species Heliopora coerulea · all data for this species · gene families
| CDS |
| ENSBQFT00000010623 |
| Protein |
| ENSBQFP00000009537.1 |
| UniProt accession | Description |
|---|---|
| Q6NYG8 | Dihydropyrimidine dehydrogenase [NADP(+)] OS=Danio rerio OX=7955 GN=dpyd PE=2 SV=1 |
| Q8CHR6 | Dihydropyrimidine dehydrogenase [NADP(+)] OS=Mus musculus OX=10090 GN=Dpyd PE=1 SV=1 |
| Q12882 | Dihydropyrimidine dehydrogenase [NADP(+)] OS=Homo sapiens OX=9606 GN=DPYD PE=1 SV=2 |
| Family type | Membership / link |
|---|---|
| Orthogroup (gene family) | OG0003061 (this species only) · gene tree & orthology |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF07992 all species → | Pyr_redox_2 | Pyridine nucleotide-disulphide oxidoreductase | Domain | Interproscan |
| PF14691 all species → | Fer4_20 | Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster | Domain | Interproscan |
| PF01180 all species → | DHO_dh | Dihydroorotate dehydrogenase | Domain | Interproscan |
| PF14697 all species → | Fer4_21 | 4Fe-4S dicluster domain | Domain | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR017900 all species → | Conserved_site | 4Fe-4S ferredoxin, iron-sulphur binding, conserved site | Interproscan |
| IPR013785 all species → | Homologous_superfamily | Aldolase-type TIM barrel | Interproscan |
| IPR023753 all species → | Domain | FAD/NAD(P)-binding domain | Interproscan |
| IPR009051 all species → | Homologous_superfamily | Alpha-helical ferredoxin | Interproscan |
| IPR028261 all species → | Domain | Dihydroprymidine dehydrogenase domain II | Interproscan |
| IPR005720 all species → | Domain | Dihydroorotate dehydrogenase, catalytic | Interproscan |
| IPR017896 all species → | Domain | 4Fe-4S ferredoxin-type, iron-sulphur binding domain | Interproscan |
| IPR036188 all species → | Homologous_superfamily | FAD/NAD(P)-binding domain superfamily | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR43073 all species → | DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)] | Interproscan |
| GO term | Category | Description | Source |
|---|---|---|---|
| GO:0016491 all species → | Molecular Function | oxidoreductase activity | Interproscan |
| GO:0051536 all species → | Molecular Function | iron-sulfur cluster binding | Interproscan |
| GO:0005737 all species → | Cellular Component | cytoplasm | Interproscan |
| GO:0016627 all species → | Molecular Function | oxidoreductase activity, acting on the CH-CH group of donors | Interproscan |
| GO:0002058 all species → | Molecular Function | uracil binding | Interproscan |
| GO:0005829 all species → | Cellular Component | cytosol | Interproscan |
| GO:0006210 all species → | Biological Process | thymine catabolic process | Interproscan |
| GO:0006212 all species → | Biological Process | uracil catabolic process | Interproscan |
| GO:0017113 all species → | Molecular Function | dihydropyrimidine dehydrogenase (NADP+) activity | Interproscan |
| GO:0050661 all species → | Molecular Function | NADP binding | Interproscan |
| KO | Enzyme | Enzyme ID | Pathway | Map ID | Source |
|---|---|---|---|---|---|
| K00207 | DPYD; dihydropyrimidine dehydrogenase (NADP+) | EC:1.3.1.2 | Drug metabolism - other enzymes | ko00983 | deepkoala |
Transcript abundance of ENSBQFP00000009537.1 across 37 RNA-seq samples of Heliopora coerulea. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.
| Condition | Samples | TPM > 0 | Mean TPM | Max TPM | Mean, relative to max |
|---|---|---|---|---|---|
| Whole coral | 17 | 17 | 31.10 | 39.30 | |
| polyp and skeleton · 31C, 3week | 6 | 6 | 7.64 | 12.80 | |
| polyp and skeleton · 28C, 3week | 6 | 5 | 13.78 | 51.61 | |
| polyp and skeleton · 26C, 3week | 4 | 3 | 4.16 | 8.34 | |
| polyp and skeleton · 28C, 24hr | 2 | 2 | 5.92 | 6.79 | |
| polyp and skeleton · 31C, 24hr | 2 | 2 | 43.50 | 75.83 |
| SRA run | Condition | Tissue | Developmental stage | Treatment | Study | TPM |
|---|---|---|---|---|---|---|
| ERR6178387 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 39.30 |
| ERR6178388 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 36.13 |
| ERR6178778 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 34.49 |
| ERR6178773 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 34.12 |
| ERR6178775 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 33.94 |
| ERR6178774 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 33.29 |
| ERR6178389 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 33.22 |
| ERR6178776 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 32.88 |
| ERR6178783 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 31.29 |
| ERR6178772 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 30.76 |
| ERR6178781 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 29.74 |
| ERR6178780 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 29.32 |
| ERR6178779 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 28.83 |
| ERR6178771 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 27.70 |
| ERR6178782 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 27.28 |
| ERR6178770 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 24.32 |
| ERR6178777 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 22.13 |
| SRR12587800 | polyp and skeleton · 31C, 3week | polyp and skeleton | not recorded | 31C, 3week | SRP115860 | 12.80 |
| SRR12587804 | polyp and skeleton · 31C, 3week | polyp and skeleton | not recorded | 31C, 3week | SRP115860 | 11.13 |
| SRR12578065 | polyp and skeleton · 31C, 3week | polyp and skeleton | not recorded | 31C, 3week | SRP115860 | 8.08 |
| SRR12578066 | polyp and skeleton · 31C, 3week | polyp and skeleton | not recorded | 31C, 3week | SRP115860 | 6.34 |
| SRR12578068 | polyp and skeleton · 31C, 3week | polyp and skeleton | not recorded | 31C, 3week | SRP115860 | 6.18 |
| SRR12587799 | polyp and skeleton · 31C, 3week | polyp and skeleton | not recorded | 31C, 3week | SRP115860 | 1.31 |
| SRR12578067 | polyp and skeleton · 28C, 3week | polyp and skeleton | not recorded | 28C, 3week | SRP115860 | 51.61 |
| SRR12587802 | polyp and skeleton · 28C, 3week | polyp and skeleton | not recorded | 28C, 3week | SRP115860 | 17.45 |
| SRR12587807 | polyp and skeleton · 28C, 3week | polyp and skeleton | not recorded | 28C, 3week | SRP115860 | 8.75 |
| SRR12587808 | polyp and skeleton · 28C, 3week | polyp and skeleton | not recorded | 28C, 3week | SRP115860 | 2.54 |
| SRR12587803 | polyp and skeleton · 28C, 3week | polyp and skeleton | not recorded | 28C, 3week | SRP115860 | 2.34 |
| SRR5949849 | polyp and skeleton · 28C, 3week | polyp and skeleton | not recorded | 28C, 3week | SRP115860 | 0.00 |
| SRR12587798 | polyp and skeleton · 26C, 3week | polyp and skeleton | not recorded | 26C, 3week | SRP115860 | 8.34 |
| SRR12587805 | polyp and skeleton · 26C, 3week | polyp and skeleton | not recorded | 26C, 3week | SRP115860 | 4.24 |
| SRR12587806 | polyp and skeleton · 26C, 3week | polyp and skeleton | not recorded | 26C, 3week | SRP115860 | 4.04 |
| SRR12587801 | polyp and skeleton · 26C, 3week | polyp and skeleton | not recorded | 26C, 3week | SRP115860 | 0.00 |
| SRR12578063 | polyp and skeleton · 28C, 24hr | polyp and skeleton | not recorded | 28C, 24hr | SRP115860 | 6.79 |
| SRR5949850 | polyp and skeleton · 28C, 24hr | polyp and skeleton | not recorded | 28C, 24hr | SRP115860 | 5.06 |
| SRR5949848 | polyp and skeleton · 31C, 24hr | polyp and skeleton | not recorded | 31C, 24hr | SRP115860 | 75.83 |
| SRR12578064 | polyp and skeleton · 31C, 24hr | polyp and skeleton | not recorded | 31C, 24hr | SRP115860 | 11.18 |
Source: CnidoSite RNA-seq expression matrices (HCOER_TPM,
StringTie quantification over 37 runs), joined to SRA sample
metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped
by the descriptor carried in the expression matrix itself.
Genes whose expression across the transcriptome samples of Heliopora coerulea tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.
| Direction | Partners | Most correlated partner | PCC |
|---|---|---|---|
| Positively correlated | 20 | ENSBQFP00000036911 | 0.880809765496194 |
| Negatively correlated | 104 | ENSBQFP00000020179 | -0.835261941138279 |
Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list. Partner counts were matched on ENSBQFP00000009537, the spelling this network uses.
Whether this gene can be visualised in the single-cell atlases of Heliopora coerulea, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.
No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.
Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.
No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.
Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.
| Analysis | What it does | Status | |
|---|---|---|---|
| Primer design | Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed. | template found | open → |
| BLAST | Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start. | template found | open → |
| Expression heatmap | Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it. | ready | open → |
| Gene family / orthogroup | Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue. | open → | |
| Gene set analysis | Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it. | open → |
