Gene detail

Detailed information of ENSBQFP00000010664.1 in Heliopora coerulea

Genomic Location: JASJOG010000026.1:1928962...1945896
NR annotation: XP_035660261.1, LOW QUALITY PROTEIN: interferon-induced GTP-binding protein Mx3-like [Branchiostoma floridae]
Species Heliopora coerulea · all data for this species · gene families

Gene Structure

More details in JBrowse

Sequence

CDS

ENSBQFT00000011844

ATGAATCAACTCGCCGTTACACAACAAGATCAGTACTTCCGGATATCTCAGTTAGATACAATGGCGACCAGTCTACAAGAAGCTTTCGAGGAAAATGTTCGACCGTTTATCGATATCATTGACGAACTTCGTTCTCTTGGTCTGGACAAAGACGTTGCTCTTCCTGCAGTTGTGGTTGTAGGGGACCAAAGTGCCGGAAAAAGCAGTGTTTTAGAAGCCATTTCTGGCGTAGAGCTGCCTCGTGGAACCAACATTGTGACAAGATGCCCGCTTGAATTGCGTCTAAAGAAAATTCGTAAAAGCAAGACTGACGAGCTACTTGGCGAAGCTGAAGCGAAAGACATTCCGTCTCCGTGGAAAGGTGCGATTTCTTACAAAATTGAAGGCACTGGTGAAGAAGTGAATGAGAAGATTGAAAGTCCCTCAGCTGTTGGTCCCGCTGTAGAGGCAGCCACTGGTAAGCTAACAAAAGGTGCAAAAGAAATTAGCGATAGCCTCATTCACCTGGAGGTTCAATCCCAAACTGTCCCAGACTTAACGCTGATTGACCTGCCTGGAATTGCCCGAGTTGCGGTAGAAGGTCAAAGTCTTAACGTTCCAGAGCTGATTAAAACACTGATTAAGAAATACGTGCAGAAAGAAGAAACCATTATTCTTGCTGTCATTCCATGTAACGTTGATATTGCTACTACTGAGGCACTGCAGCTCGCTCAACAGGTTGATCCAGACGGAAAACGAACCCTTGGCGTCCTGACCAAACCTGATCTGATGGACGAGGGAACGGAAAGCGATATATGTAACATAGTGAACGGTGAAAAGGTGAAACTGAAGTTGGGTTATACTGTGGTGAAATGTCGTGGGCAAAAGGCTATCGAAAGTAAACTGTCTTTGGAAGATGCCAttcaaaatgaggaaaatttcttcaaaaaccaCGAAGTGCTTGGAGTTTTGTATCAAGAGAAAAAGACCGGAATTCAGAATTTGTCGCACCAGTTAACCAAACAACTGGTGGAGCAGATTAAGACCAACATGCCGGGTTTGAAGTCTGATATCACCAAAAAGCTGTCGTTGGTAAACGAACTCCTTGAGAAATATGGTGAAAGTCTTCCCGAAGAGGATCACGATCGACAAAACTTTCTGTTCAAActtttaatgaaacttGGGGAAACTTTTAAAAGGTTGGCGAACGTAGAATACATCGATGAGGAATCATTGAACGCCCTAAGGTTATTTGCGAATTGTAAAAAAGAGTTTGCTGATCTTGCGAGGCAAATTCGTATGCTTAAACCAAGGCGTATAGATCCTAATCTTAAGTCAGAGGTATCTAAGGAAATCAAGAAGCAAAAGGGCAAGGAATTACCTAGTTTCTTGTCCTATAAAGTATTTGAAATCATCGTCAAAAAACACATCAAAAAAATCGAGTCACCAGCGAATGATTGCCTTAAGAAAGTCAATAATATTGTCGAGGAGATTGCATCAATTGCGATCAAGAAATATCTTGACAGATTTGAGCCGCTTATGATGGAAGTGAACAAACTGATGAACGAGGAAAGAATGAAGGCCAAGAGGAATACAGAAGACGCGCTGAAGACGATCTTTGCGATGGAATACTTGGTGTTCACGCAAGATGGAAATTTTACCCGACTTATGAAAGACATCGAGAAAGAAGATCAAGAAGAAAGTCCAAAGGGGAAAAATCGAATTGTGAGACGTATTTACGATTGGTTTGCAGAAGGCGAGAAAATGGACGCTGAGCACATGGTGAAATGCTTGGAAGCTTATTGTGATGTTGCTGTTACTCGATTGGTCGACACAGTTCCTATGGCTATATATTATCACCTCGTTAAACAATTACTGGAAGGCATGGTTACCGAAATGATTAAGATTGCCTCTAAACCGAATTCCCACAACGAGCTTTTGAAAGAAGATCCCGAGATTGTTTTTAcgaaaaagaatttattggaAAAGCAGCAGAGGCTCGAGAAGGCGAATATAAAGCTGATGAAGTTCGGTTGTTCGACTTCCGAAACAAGCTATCTTTATTCAGAAGAAGAAGACGACGACGATGATCTTTAG

Protein

UniProt (Swiss-Prot top hit)

UniProt accession	Description
Q91197	Interferon-induced GTP-binding protein Mx3 OS=Oncorhynchus mykiss OX=8022 GN=mx3 PE=2 SV=1
Q91192	Interferon-induced GTP-binding protein Mx1 OS=Oncorhynchus mykiss OX=8022 GN=mx1 PE=2 SV=1
Q7T2P0	Interferon-induced GTP-binding protein Mx1 OS=Ictalurus punctatus OX=7998 GN=mx1 PE=2 SV=1

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0014538 (this species only) · gene tree & orthology

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF00350 all species →	Dynamin_N	Dynamin family	Domain	Interproscan
PF02212 all species →	GED	Dynamin GTPase effector domain	Family	Interproscan
PF01031 all species →	Dynamin_M	Dynamin central region	Family	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR022812 all species →	Family	Dynamin	Interproscan
IPR030381 all species →	Domain	Dynamin-type guanine nucleotide-binding (G) domain	Interproscan
IPR027417 all species →	Homologous_superfamily	P-loop containing nucleoside triphosphate hydrolase	Interproscan
IPR001401 all species →	Domain	Dynamin, GTPase domain	Interproscan
IPR045063 all species →	Domain	Dynamin, N-terminal	Interproscan
IPR003130 all species →	Domain	Dynamin GTPase effector	Interproscan
IPR000375 all species →	Domain	Dynamin stalk domain	Interproscan
IPR019762 all species →	Conserved_site	Dynamin, GTPase region, conserved site	Interproscan
IPR020850 all species →	Domain	GTPase effector domain	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR11566 all species →	DYNAMIN	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0005525 all species →	Molecular Function	GTP binding	Interproscan
GO:0003924 all species →	Molecular Function	GTPase activity	Interproscan
GO:0005737 all species →	Cellular Component	cytoplasm	Interproscan
GO:0005874 all species →	Cellular Component	microtubule	Interproscan
GO:0008017 all species →	Molecular Function	microtubule binding	Interproscan
GO:0016020 all species →	Cellular Component	membrane	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

KO	Enzyme	Enzyme ID	Pathway	Map ID	Source
K14754	MX; interferon-induced GTP-binding protein Mx	-	Human papillomavirus infection	ko05165	deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Expression pattern (RNA-seq)

Transcript abundance of ENSBQFP00000010664.1 across 37 RNA-seq samples of Heliopora coerulea. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.

37Samples

34TPM > 0

6Conditions

115.5Max TPM

23.6Mean TPM

By condition

Condition	Samples	TPM > 0	Mean TPM	Max TPM
Whole coral	17	17	24.64	38.05
polyp and skeleton · 31C, 3week	6	6	20.76	34.50
polyp and skeleton · 28C, 3week	6	4	17.42	47.06
polyp and skeleton · 26C, 3week	4	4	41.37	115.54
polyp and skeleton · 28C, 24hr	2	2	10.33	12.57
polyp and skeleton · 31C, 24hr	2	1	19.81	39.62

Per sample · hover a bar for the full sample record

Show the sample table (37 samples)

SRA run	Condition	Tissue	Developmental stage	Treatment	Study	TPM
ERR6178775	Whole coral	Whole coral	not recorded	not recorded	ERP120267	38.05
ERR6178387	Whole coral	Whole coral	not recorded	not recorded	ERP120267	37.03
ERR6178772	Whole coral	Whole coral	not recorded	not recorded	ERP120267	35.90
ERR6178773	Whole coral	Whole coral	not recorded	not recorded	ERP120267	33.22
ERR6178782	Whole coral	Whole coral	not recorded	not recorded	ERP120267	26.35
ERR6178780	Whole coral	Whole coral	not recorded	not recorded	ERP120267	23.86
ERR6178388	Whole coral	Whole coral	not recorded	not recorded	ERP120267	23.29
ERR6178776	Whole coral	Whole coral	not recorded	not recorded	ERP120267	23.25
ERR6178770	Whole coral	Whole coral	not recorded	not recorded	ERP120267	22.25
ERR6178781	Whole coral	Whole coral	not recorded	not recorded	ERP120267	22.17
ERR6178778	Whole coral	Whole coral	not recorded	not recorded	ERP120267	21.41
ERR6178779	Whole coral	Whole coral	not recorded	not recorded	ERP120267	20.61
ERR6178774	Whole coral	Whole coral	not recorded	not recorded	ERP120267	20.50
ERR6178389	Whole coral	Whole coral	not recorded	not recorded	ERP120267	18.74
ERR6178783	Whole coral	Whole coral	not recorded	not recorded	ERP120267	18.30
ERR6178777	Whole coral	Whole coral	not recorded	not recorded	ERP120267	17.37
ERR6178771	Whole coral	Whole coral	not recorded	not recorded	ERP120267	16.61
SRR12578068	polyp and skeleton · 31C, 3week	polyp and skeleton	not recorded	31C, 3week	SRP115860	34.50
SRR12578065	polyp and skeleton · 31C, 3week	polyp and skeleton	not recorded	31C, 3week	SRP115860	26.80
SRR12578066	polyp and skeleton · 31C, 3week	polyp and skeleton	not recorded	31C, 3week	SRP115860	26.39
SRR12587800	polyp and skeleton · 31C, 3week	polyp and skeleton	not recorded	31C, 3week	SRP115860	23.08
SRR12587804	polyp and skeleton · 31C, 3week	polyp and skeleton	not recorded	31C, 3week	SRP115860	8.45
SRR12587799	polyp and skeleton · 31C, 3week	polyp and skeleton	not recorded	31C, 3week	SRP115860	5.32
SRR12587802	polyp and skeleton · 28C, 3week	polyp and skeleton	not recorded	28C, 3week	SRP115860	47.06
SRR12587807	polyp and skeleton · 28C, 3week	polyp and skeleton	not recorded	28C, 3week	SRP115860	28.11
SRR12587803	polyp and skeleton · 28C, 3week	polyp and skeleton	not recorded	28C, 3week	SRP115860	14.93
SRR12587808	polyp and skeleton · 28C, 3week	polyp and skeleton	not recorded	28C, 3week	SRP115860	14.44
SRR12578067	polyp and skeleton · 28C, 3week	polyp and skeleton	not recorded	28C, 3week	SRP115860	0.00
SRR5949849	polyp and skeleton · 28C, 3week	polyp and skeleton	not recorded	28C, 3week	SRP115860	0.00
SRR12587801	polyp and skeleton · 26C, 3week	polyp and skeleton	not recorded	26C, 3week	SRP115860	115.54
SRR12587806	polyp and skeleton · 26C, 3week	polyp and skeleton	not recorded	26C, 3week	SRP115860	44.83
SRR12587798	polyp and skeleton · 26C, 3week	polyp and skeleton	not recorded	26C, 3week	SRP115860	3.93
SRR12587805	polyp and skeleton · 26C, 3week	polyp and skeleton	not recorded	26C, 3week	SRP115860	1.17
SRR12578063	polyp and skeleton · 28C, 24hr	polyp and skeleton	not recorded	28C, 24hr	SRP115860	12.57
SRR5949850	polyp and skeleton · 28C, 24hr	polyp and skeleton	not recorded	28C, 24hr	SRP115860	8.09
SRR12578064	polyp and skeleton · 31C, 24hr	polyp and skeleton	not recorded	31C, 24hr	SRP115860	39.62
SRR5949848	polyp and skeleton · 31C, 24hr	polyp and skeleton	not recorded	31C, 24hr	SRP115860	0.00

Source: CnidoSite RNA-seq expression matrices (HCOER_TPM, StringTie quantification over 37 runs), joined to SRA sample metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped by the descriptor carried in the expression matrix itself.

Co-expression network

Genes whose expression across the transcriptome samples of Heliopora coerulea tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

Direction	Partners	Most correlated partner	PCC
Positively correlated	9	ENSBQFP00000048844	0.860651187764212
Negatively correlated	5	ENSBQFP00000004616	-0.617326922120137

Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list. Partner counts were matched on ENSBQFP00000010664, the spelling this network uses.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Heliopora coerulea, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

Analysis	What it does	Status
Primer design	Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.	template found	open →
BLAST	Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.	template found	open →
Expression heatmap	Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.	ready	open →
Gene family / orthogroup	Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.		open →
Gene set analysis	Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.		open →