Gene detail

Detailed information of ENSBQFP00000017586.1 in Heliopora coerulea

Genomic Location: JASJOG010000031.1:1637873...1650425
NR annotation: CAB3982901.1, heat shock HSP 90-alpha [Paramuricea clavata]
Species Heliopora coerulea · all data for this species · gene families

Gene Structure

More details in JBrowse

Sequence

CDS

ENSBQFT00000019632

ATGACTGAAACCGAGATGAAAAACATGGAGGAAGATAATGAGGTTGAAACATTTGCTTTCCAGGCAGAAATTGCTCAGCTGATGAGCCTCATCATCAACACTTTCTATTCCAACAAGGAAATTTTCCTCAGGGAACTCGTATCCAATGCATCTGATGCGCTGGATAAAATACGTTATCAAAGTCTGACGGATCCCGCTAAATTGGACACTTGCAAAGACCTGAAAATTGAAGTTATTCCTAACAAGGATGACAATACATTAACCCTCATTGACACTGGGATTGGCATGACTAAAGCAGATCTGGTTAATAATTTGGGTACCATTGCAAAATCAGGCACCAAAGCTTTCATGGAGGCTTTGCAGTCTGGAGCAGACATTTCTATGATTGGTCAATTTGGTGTTGGGTTTTACTCTGCATACTTGGTGGCTGAAAAAGTAGTTGTGACTACCAAACACAATGATGACGAGCAGTATGTGTGGGAATCTTCTGCTGGTGGATCATTCACTGTGGCAAAGGATGACAGTGAAATGTATGGGCGTGGGACTAAGATTGTCCTTCACATGAAAGAAGACCAGCTTGAATATCTTGATGAGAAAAGGGTGAAAGACATTGTTAAAAAGCACAGCCAGTTTATTGGGTATCCTATCGTATTAAAGGTTCagaaagaacgagaaaaggaAGTGAGcgatgatgaggatgaagacgaagaggaggaagaagacaagaaggaagagaagaagGAGCCTGCTGAGAATGGGGAAGCCGAAGATCAAGAAAAGGCCAAAATCGAAGACcttgatgaagaagaagaaagtaaagaaaaagacgagaagaaaaagaagaaaataacgGAGAAGTATATTGATGAAGAAGAGCTGAACAAAACAAAGCCGATCTGGATGCGAAATACGAGTGACATCACGAATGAACAATACGCCGAGTTCTACAAGAGCCTTACCAATGACTGGGAGGAACATCTTGCGGTAAAGCACTTCTCTGTCGAAGGCCAGCTGGAGTTCCGAGCCATCTTGTTTGTGCCGAAACGCGCCCCGTTCGACCTGTTCGAAAACCGCAAAAAGAGGAACAACATTAAGCTGTACGTGAGGAGGGTGTTCATCATGGACACCTGCGATGATCTGATTCCGGAGTACCTGAATTTTGTCAAGGGTGTCGTTGATTCGGAAGATTTGCCGTTGAACATCTCCCGAGAGACCCTGCAGCAGAGCAAAATCCTGAAGGTTATCCGCAAGAACCTCGTCAAGAAGTGCTTGGAGCTTTTCAATGAAATTTCGCAGGACAAGGACAACTACAAGACCTTCTACGATCAGTTTTCGAAAAACCTGAAGTTGGCCATCCACGAAGACAGCACCAACCGAGCGAAACTGGCCGACCTGCTCCGTTACCACTCCTCTTCCTCTGGCGATGAGTTGTGCTCCCTGAAAGACTACGTCTCAAGAATGAAAGAAGTCCAGAAGGATATCTACTACATCACTGGGGAATCAAAGGAACAGGTTGCCAACTCCGTGTTCGTGGAACGTGTTAAAAAACGTGGCTTTGAAGTGCTCTACATGACTGAACCAATTGATGAATACGCCGTTCAGCAGCTGAAGGAGTATGACGGCAAGAAGCTTGTGAGCGTGACCAAAGAAGGCCTTGAGTTGCCGGAAGACGAAGAGGAGAAGAAGAAACGTGAAGAACaaaaggctaatttcgaagaaCTCTGCAAGCTTATTAAGGAGATTCTTGACAAGAAGATAGAAAAAGTTGTGCTGTCGAACCGTCTCGTATCTTCGCCTTGTTGCATTGTGACAAGCCAGTATGGCTGGTCTGCGAACATGGAACGGATCATGAAGGCGCAGGCACTGCGGGATTCTAGCACCATGGGCTATATGGCAGCCAAGAAGCACTTGGAGATCAATCCTGATCATCCCATCATCATCGCTTTGAACAAGAAGGTTTCGGAAGACAAGAACGACAAGTCAGTCAAAGATTTGGTTCATTTGCTTTTTGAAACTTCTTTGCTCTCCTCAGGATTTTCCCTCGATGACCCACAGGTTCATTCCGCTCGTATTTACCGAATGATCAACCTTGGTCTCGGAATAGATGAAGATTTTGAGGGGCCAGAAGATGCCGAGAGCACCGAAGACATGCCGCCATTAGAGGGAGACGAGGAATCATCGAAGATGGAGGAAGTTGACTAG

Protein

UniProt (Swiss-Prot top hit)

UniProt accession	Description
Q9GKX8	Heat shock protein HSP 90-beta OS=Equus caballus OX=9796 GN=HSP90AB1 PE=2 SV=3
P08238	Heat shock protein HSP 90-beta OS=Homo sapiens OX=9606 GN=HSP90AB1 PE=1 SV=4
Q4R4T5	Heat shock protein HSP 90-beta OS=Macaca fascicularis OX=9541 GN=HSP90AB1 PE=2 SV=1

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0001818 (this species only) · gene tree & orthology

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF13589 all species →	HATPase_c_3	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	Domain	Interproscan
PF00183 all species →	HSP90	Hsp90 protein	Family	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR037196 all species →	Homologous_superfamily	HSP90, C-terminal domain	Interproscan
IPR019805 all species →	Conserved_site	Heat shock protein Hsp90, conserved site	Interproscan
IPR003594 all species →	Domain	Histidine kinase/HSP90-like ATPase	Interproscan
IPR020575 all species →	Domain	Heat shock protein Hsp90, N-terminal	Interproscan
IPR001404 all species →	Family	Heat shock protein Hsp90 family	Interproscan
IPR036890 all species →	Homologous_superfamily	Histidine kinase/HSP90-like ATPase superfamily	Interproscan
IPR020568 all species →	Homologous_superfamily	Ribosomal protein uS5 domain 2-type superfamily	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR11528 all species →	HEAT SHOCK PROTEIN 90 FAMILY MEMBER	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0005524 all species →	Molecular Function	ATP binding	Interproscan
GO:0006457 all species →	Biological Process	protein folding	Interproscan
GO:0051082 all species →	Molecular Function	unfolded protein binding	Interproscan
GO:0005829 all species →	Cellular Component	cytosol	Interproscan
GO:0005886 all species →	Cellular Component	plasma membrane	Interproscan
GO:0016887 all species →	Molecular Function	ATP hydrolysis activity	Interproscan
GO:0032991 all species →	Cellular Component	protein-containing complex	Interproscan
GO:0034605 all species →	Biological Process	cellular response to heat	Interproscan
GO:0048471 all species →	Cellular Component	perinuclear region of cytoplasm	Interproscan
GO:0050821 all species →	Biological Process	protein stabilization	Interproscan
GO:0140662 all species →	Molecular Function	ATP-dependent protein folding chaperone	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

KO	Enzyme	Enzyme ID	Pathway	Map ID	Source
K04079	HSP90A, htpG; molecular chaperone HtpG	-	Exosome	ko04147	deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Expression pattern (RNA-seq)

Transcript abundance of ENSBQFP00000017586.1 across 37 RNA-seq samples of Heliopora coerulea. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.

37Samples

37TPM > 0

6Conditions

1,376.6Max TPM

812.4Mean TPM

By condition

Condition	Samples	TPM > 0	Mean TPM	Max TPM
Whole coral	17	17	767.18	1,023.01
polyp and skeleton · 31C, 3week	6	6	803.90	1,159.00
polyp and skeleton · 28C, 3week	6	6	997.39	1,376.58
polyp and skeleton · 26C, 3week	4	4	760.06	1,002.75
polyp and skeleton · 28C, 24hr	2	2	672.53	749.79
polyp and skeleton · 31C, 24hr	2	2	912.16	926.89

Per sample · hover a bar for the full sample record

Show the sample table (37 samples)

SRA run	Condition	Tissue	Developmental stage	Treatment	Study	TPM
ERR6178774	Whole coral	Whole coral	not recorded	not recorded	ERP120267	1,023.01
ERR6178775	Whole coral	Whole coral	not recorded	not recorded	ERP120267	1,020.46
ERR6178773	Whole coral	Whole coral	not recorded	not recorded	ERP120267	923.85
ERR6178388	Whole coral	Whole coral	not recorded	not recorded	ERP120267	888.68
ERR6178778	Whole coral	Whole coral	not recorded	not recorded	ERP120267	844.32
ERR6178780	Whole coral	Whole coral	not recorded	not recorded	ERP120267	826.16
ERR6178387	Whole coral	Whole coral	not recorded	not recorded	ERP120267	764.45
ERR6178781	Whole coral	Whole coral	not recorded	not recorded	ERP120267	747.36
ERR6178772	Whole coral	Whole coral	not recorded	not recorded	ERP120267	737.64
ERR6178771	Whole coral	Whole coral	not recorded	not recorded	ERP120267	727.68
ERR6178389	Whole coral	Whole coral	not recorded	not recorded	ERP120267	715.63
ERR6178779	Whole coral	Whole coral	not recorded	not recorded	ERP120267	688.55
ERR6178776	Whole coral	Whole coral	not recorded	not recorded	ERP120267	686.09
ERR6178783	Whole coral	Whole coral	not recorded	not recorded	ERP120267	661.44
ERR6178777	Whole coral	Whole coral	not recorded	not recorded	ERP120267	651.78
ERR6178770	Whole coral	Whole coral	not recorded	not recorded	ERP120267	616.71
ERR6178782	Whole coral	Whole coral	not recorded	not recorded	ERP120267	518.22
SRR12578065	polyp and skeleton · 31C, 3week	polyp and skeleton	not recorded	31C, 3week	SRP115860	1,159.00
SRR12578068	polyp and skeleton · 31C, 3week	polyp and skeleton	not recorded	31C, 3week	SRP115860	931.93
SRR12587804	polyp and skeleton · 31C, 3week	polyp and skeleton	not recorded	31C, 3week	SRP115860	834.38
SRR12587800	polyp and skeleton · 31C, 3week	polyp and skeleton	not recorded	31C, 3week	SRP115860	736.44
SRR12578066	polyp and skeleton · 31C, 3week	polyp and skeleton	not recorded	31C, 3week	SRP115860	651.54
SRR12587799	polyp and skeleton · 31C, 3week	polyp and skeleton	not recorded	31C, 3week	SRP115860	510.09
SRR12578067	polyp and skeleton · 28C, 3week	polyp and skeleton	not recorded	28C, 3week	SRP115860	1,376.58
SRR12587803	polyp and skeleton · 28C, 3week	polyp and skeleton	not recorded	28C, 3week	SRP115860	1,284.60
SRR5949849	polyp and skeleton · 28C, 3week	polyp and skeleton	not recorded	28C, 3week	SRP115860	1,104.28
SRR12587802	polyp and skeleton · 28C, 3week	polyp and skeleton	not recorded	28C, 3week	SRP115860	840.98
SRR12587808	polyp and skeleton · 28C, 3week	polyp and skeleton	not recorded	28C, 3week	SRP115860	785.67
SRR12587807	polyp and skeleton · 28C, 3week	polyp and skeleton	not recorded	28C, 3week	SRP115860	592.23
SRR12587806	polyp and skeleton · 26C, 3week	polyp and skeleton	not recorded	26C, 3week	SRP115860	1,002.75
SRR12587801	polyp and skeleton · 26C, 3week	polyp and skeleton	not recorded	26C, 3week	SRP115860	807.88
SRR12587798	polyp and skeleton · 26C, 3week	polyp and skeleton	not recorded	26C, 3week	SRP115860	626.62
SRR12587805	polyp and skeleton · 26C, 3week	polyp and skeleton	not recorded	26C, 3week	SRP115860	603.00
SRR5949850	polyp and skeleton · 28C, 24hr	polyp and skeleton	not recorded	28C, 24hr	SRP115860	749.79
SRR12578063	polyp and skeleton · 28C, 24hr	polyp and skeleton	not recorded	28C, 24hr	SRP115860	595.27
SRR5949848	polyp and skeleton · 31C, 24hr	polyp and skeleton	not recorded	31C, 24hr	SRP115860	926.89
SRR12578064	polyp and skeleton · 31C, 24hr	polyp and skeleton	not recorded	31C, 24hr	SRP115860	897.44

Source: CnidoSite RNA-seq expression matrices (HCOER_TPM, StringTie quantification over 37 runs), joined to SRA sample metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped by the descriptor carried in the expression matrix itself.

Co-expression network

Genes whose expression across the transcriptome samples of Heliopora coerulea tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

Direction	Partners	Most correlated partner	PCC
Positively correlated	7	ENSBQFP00000021200	0.854608407488171
Negatively correlated	473	ENSBQFP00000028440	-0.734589033819188

Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list. Partner counts were matched on ENSBQFP00000017586, the spelling this network uses.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Heliopora coerulea, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

Analysis	What it does	Status
Primer design	Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.	template found	open →
BLAST	Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.	template found	open →
Expression heatmap	Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.	ready	open →
Gene family / orthogroup	Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.		open →
Gene set analysis	Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.		open →