Gene detail

Detailed information of ENSBQFP00000017671.1 in Heliopora coerulea

Genomic Location: JASJOG010000048.1:255801...288826
NR annotation: XP_028397905.1, phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2-like isoform X2 [Dendronephthya gigantea]
Species Heliopora coerulea · all data for this species · gene families

Gene Structure

More details in JBrowse

Sequence

CDS

Protein

UniProt (Swiss-Prot top hit)

UniProt accession	Description
Q6XPS3	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 OS=Homo sapiens OX=9606 GN=TPTE2 PE=1 SV=2
Q4R6N0	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 OS=Macaca fascicularis OX=9541 GN=TPTE2 PE=2 SV=1
P56180	Putative tyrosine-protein phosphatase TPTE OS=Homo sapiens OX=9606 GN=TPTE PE=1 SV=3

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0001472 (this species only) · gene tree & orthology

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF10409 all species →	PTEN_C2	C2 domain of PTEN tumour-suppressor protein	Domain	Interproscan
PF00520 all species →	Ion_trans	Ion transport protein	Family	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR029021 all species →	Homologous_superfamily	Protein-tyrosine phosphatase-like	Interproscan
IPR000387 all species →	Domain	Tyrosine-specific protein phosphatases domain	Interproscan
IPR003595 all species →	Domain	Protein-tyrosine phosphatase, catalytic	Interproscan
IPR045102 all species →	Domain	TPTE, protein tyrosine phosphatase-like catalytic domain	Interproscan
IPR027359 all species →	Homologous_superfamily	Voltage-dependent channel domain superfamily	Interproscan
IPR014020 all species →	Domain	Tensin phosphatase, C2 domain	Interproscan
IPR035892 all species →	Homologous_superfamily	C2 domain superfamily	Interproscan
IPR051281 all species →	Family	Dual-specificity lipid and protein phosphatase	Interproscan
IPR016130 all species →	Active_site	Protein-tyrosine phosphatase, active site	Interproscan
IPR005821 all species →	Domain	Ion transport domain	Interproscan
IPR029023 all species →	Domain	Tensin-type phosphatase domain	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR12305 all species →	PHOSPHATASE WITH HOMOLOGY TO TENSIN	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0016311 all species →	Biological Process	dephosphorylation	Interproscan
GO:0004725 all species →	Molecular Function	protein tyrosine phosphatase activity	Interproscan
GO:0005634 all species →	Cellular Component	nucleus	Interproscan
GO:0005829 all species →	Cellular Component	cytosol	Interproscan
GO:0005886 all species →	Cellular Component	plasma membrane	Interproscan
GO:0006470 all species →	Biological Process	protein dephosphorylation	Interproscan
GO:0008285 all species →	Biological Process	negative regulation of cell population proliferation	Interproscan
GO:0014065 all species →	Biological Process	obsolete phosphatidylinositol 3-kinase signaling	Interproscan
GO:0016314 all species →	Molecular Function	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	Interproscan
GO:0042995 all species →	Cellular Component	cell projection	Interproscan
GO:0046856 all species →	Biological Process	phosphatidylinositol dephosphorylation	Interproscan
GO:0048870 all species →	Biological Process	cell motility	Interproscan
GO:0051896 all species →	Biological Process	regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Interproscan
GO:0005216 all species →	Molecular Function	monoatomic ion channel activity	Interproscan
GO:0006811 all species →	Biological Process	monoatomic ion transport	Interproscan
GO:0016020 all species →	Cellular Component	membrane	Interproscan
GO:0055085 all species →	Biological Process	transmembrane transport	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

KO	Enzyme	Enzyme ID	Pathway	Map ID	Source
K18079	TPTE, TPIP; PTEN homologous phosphatase	-	Protein phosphatases and associated proteins	ko01009	deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Expression pattern (RNA-seq)

Transcript abundance of ENSBQFP00000017671.1 across 37 RNA-seq samples of Heliopora coerulea. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.

37Samples

34TPM > 0

6Conditions

52.2Max TPM

13.8Mean TPM

By condition

Condition	Samples	TPM > 0	Mean TPM	Max TPM
Whole coral	17	17	9.56	29.52
polyp and skeleton · 31C, 3week	6	6	17.78	25.26
polyp and skeleton · 28C, 3week	6	4	11.67	23.42
polyp and skeleton · 26C, 3week	4	4	29.41	52.20
polyp and skeleton · 28C, 24hr	2	2	20.60	21.34
polyp and skeleton · 31C, 24hr	2	1	5.54	11.08

Per sample · hover a bar for the full sample record

Show the sample table (37 samples)

SRA run	Condition	Tissue	Developmental stage	Treatment	Study	TPM
ERR6178771	Whole coral	Whole coral	not recorded	not recorded	ERP120267	29.52
ERR6178781	Whole coral	Whole coral	not recorded	not recorded	ERP120267	16.10
ERR6178775	Whole coral	Whole coral	not recorded	not recorded	ERP120267	12.03
ERR6178772	Whole coral	Whole coral	not recorded	not recorded	ERP120267	10.81
ERR6178776	Whole coral	Whole coral	not recorded	not recorded	ERP120267	10.19
ERR6178770	Whole coral	Whole coral	not recorded	not recorded	ERP120267	9.32
ERR6178782	Whole coral	Whole coral	not recorded	not recorded	ERP120267	9.05
ERR6178773	Whole coral	Whole coral	not recorded	not recorded	ERP120267	8.04
ERR6178783	Whole coral	Whole coral	not recorded	not recorded	ERP120267	7.99
ERR6178779	Whole coral	Whole coral	not recorded	not recorded	ERP120267	7.74
ERR6178778	Whole coral	Whole coral	not recorded	not recorded	ERP120267	7.69
ERR6178780	Whole coral	Whole coral	not recorded	not recorded	ERP120267	7.17
ERR6178777	Whole coral	Whole coral	not recorded	not recorded	ERP120267	6.27
ERR6178389	Whole coral	Whole coral	not recorded	not recorded	ERP120267	5.59
ERR6178388	Whole coral	Whole coral	not recorded	not recorded	ERP120267	5.11
ERR6178774	Whole coral	Whole coral	not recorded	not recorded	ERP120267	5.07
ERR6178387	Whole coral	Whole coral	not recorded	not recorded	ERP120267	4.77
SRR12587804	polyp and skeleton · 31C, 3week	polyp and skeleton	not recorded	31C, 3week	SRP115860	25.26
SRR12587800	polyp and skeleton · 31C, 3week	polyp and skeleton	not recorded	31C, 3week	SRP115860	21.06
SRR12587799	polyp and skeleton · 31C, 3week	polyp and skeleton	not recorded	31C, 3week	SRP115860	20.27
SRR12578068	polyp and skeleton · 31C, 3week	polyp and skeleton	not recorded	31C, 3week	SRP115860	16.03
SRR12578065	polyp and skeleton · 31C, 3week	polyp and skeleton	not recorded	31C, 3week	SRP115860	12.73
SRR12578066	polyp and skeleton · 31C, 3week	polyp and skeleton	not recorded	31C, 3week	SRP115860	11.32
SRR12587802	polyp and skeleton · 28C, 3week	polyp and skeleton	not recorded	28C, 3week	SRP115860	23.42
SRR12587808	polyp and skeleton · 28C, 3week	polyp and skeleton	not recorded	28C, 3week	SRP115860	16.49
SRR12587807	polyp and skeleton · 28C, 3week	polyp and skeleton	not recorded	28C, 3week	SRP115860	16.04
SRR12587803	polyp and skeleton · 28C, 3week	polyp and skeleton	not recorded	28C, 3week	SRP115860	14.05
SRR12578067	polyp and skeleton · 28C, 3week	polyp and skeleton	not recorded	28C, 3week	SRP115860	0.00
SRR5949849	polyp and skeleton · 28C, 3week	polyp and skeleton	not recorded	28C, 3week	SRP115860	0.00
SRR12587806	polyp and skeleton · 26C, 3week	polyp and skeleton	not recorded	26C, 3week	SRP115860	52.20
SRR12587801	polyp and skeleton · 26C, 3week	polyp and skeleton	not recorded	26C, 3week	SRP115860	35.03
SRR12587798	polyp and skeleton · 26C, 3week	polyp and skeleton	not recorded	26C, 3week	SRP115860	16.57
SRR12587805	polyp and skeleton · 26C, 3week	polyp and skeleton	not recorded	26C, 3week	SRP115860	13.85
SRR12578063	polyp and skeleton · 28C, 24hr	polyp and skeleton	not recorded	28C, 24hr	SRP115860	21.34
SRR5949850	polyp and skeleton · 28C, 24hr	polyp and skeleton	not recorded	28C, 24hr	SRP115860	19.87
SRR12578064	polyp and skeleton · 31C, 24hr	polyp and skeleton	not recorded	31C, 24hr	SRP115860	11.08
SRR5949848	polyp and skeleton · 31C, 24hr	polyp and skeleton	not recorded	31C, 24hr	SRP115860	0.00

Source: CnidoSite RNA-seq expression matrices (HCOER_TPM, StringTie quantification over 37 runs), joined to SRA sample metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped by the descriptor carried in the expression matrix itself.

Co-expression network

Genes whose expression across the transcriptome samples of Heliopora coerulea tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

Direction	Partners	Most correlated partner	PCC
Positively correlated	22	ENSBQFP00000006091	0.857643806749449
Negatively correlated	6	ENSBQFP00000017481	-0.609519802236322

Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list. Partner counts were matched on ENSBQFP00000017671, the spelling this network uses.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Heliopora coerulea, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

Analysis	What it does	Status
Primer design	Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.	template found	open →
BLAST	Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.	template found	open →
Expression heatmap	Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.	ready	open →
Gene family / orthogroup	Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.		open →
Gene set analysis	Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.		open →