Genomic Location: JASJOG010000134.1:898196...925112
NR annotation: XP_028398564.1, E3 ubiquitin-protein ligase HECTD1-like [Dendronephthya gigantea]
Species Heliopora coerulea · all data for this species · gene families
| CDS |
| ENSBQFT00000038879 |
| Protein |
| ENSBQFP00000034690.1 |
| UniProt accession | Description |
|---|---|
| Q9ULT8 | E3 ubiquitin-protein ligase HECTD1 OS=Homo sapiens OX=9606 GN=HECTD1 PE=1 SV=4 |
| Q69ZR2 | E3 ubiquitin-protein ligase HECTD1 OS=Mus musculus OX=10090 GN=Hectd1 PE=1 SV=2 |
| Q9VL06 | E3 ubiquitin-protein ligase Ufd4 OS=Drosophila melanogaster OX=7227 GN=Ufd4 PE=2 SV=1 |
| Family type | Membership / link |
|---|---|
| Orthogroup (gene family) | OG0003347 (this species only) · gene tree & orthology |
| Ubiquitin family | E3|E3 activity|HECT · all ubiquitin genes in this species |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF07738 all species → | Sad1_UNC | Sad1 / UNC-like C-terminal | Family | Interproscan |
| PF00632 all species → | HECT | HECT-domain (ubiquitin-transferase) | Domain | Interproscan |
| PF18410 all species → | BTHB | Basic tilted helix bundle domain | Domain | Interproscan |
| PF12796 all species → | Ank_2 | Ankyrin repeats (3 copies) | Repeat | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR012919 all species → | Domain | SUN domain | Interproscan |
| IPR035983 all species → | Homologous_superfamily | HECT, E3 ligase catalytic domain | Interproscan |
| IPR008979 all species → | Homologous_superfamily | Galactose-binding-like domain superfamily | Interproscan |
| IPR000569 all species → | Domain | HECT domain | Interproscan |
| IPR011989 all species → | Homologous_superfamily | Armadillo-like helical | Interproscan |
| IPR045322 all species → | Family | E3 ubiquitin-protein ligase HECTD1/TRIP12-like | Interproscan |
| IPR016024 all species → | Homologous_superfamily | Armadillo-type fold | Interproscan |
| IPR002110 all species → | Repeat | Ankyrin repeat | Interproscan |
| IPR041200 all species → | Domain | FKBP3, basic tilted helix bundle domain | Interproscan |
| IPR036770 all species → | Homologous_superfamily | Ankyrin repeat-containing domain superfamily | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR45670 all species → | E3 UBIQUITIN-PROTEIN LIGASE TRIP12 | Interproscan |
| GO term | Category | Description | Source |
|---|---|---|---|
| GO:0004842 all species → | Molecular Function | ubiquitin-protein transferase activity | Interproscan |
| GO:0000209 all species → | Biological Process | protein polyubiquitination | Interproscan |
| GO:0006511 all species → | Biological Process | ubiquitin-dependent protein catabolic process | Interproscan |
| GO:0016607 all species → | Cellular Component | nuclear speck | Interproscan |
| GO:0043161 all species → | Biological Process | proteasome-mediated ubiquitin-dependent protein catabolic process | Interproscan |
| GO:0048856 all species → | Biological Process | anatomical structure development | Interproscan |
| GO:0061630 all species → | Molecular Function | ubiquitin protein ligase activity | Interproscan |
| GO:0070534 all species → | Biological Process | protein K63-linked ubiquitination | Interproscan |
| GO:0005515 all species → | Molecular Function | protein binding | Interproscan |
| KO | Enzyme | Enzyme ID | Pathway | Map ID | Source |
|---|---|---|---|---|---|
| K12231 | HECTD1; E3 ubiquitin-protein ligase HECTD1 | EC:2.3.2.26 | Ubiquitin system | ko04121 | deepkoala |
Transcript abundance of ENSBQFP00000034690.1 across 37 RNA-seq samples of Heliopora coerulea. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.
| Condition | Samples | TPM > 0 | Mean TPM | Max TPM | Mean, relative to max |
|---|---|---|---|---|---|
| Whole coral | 17 | 17 | 30.21 | 39.81 | |
| polyp and skeleton · 31C, 3week | 6 | 6 | 38.59 | 53.25 | |
| polyp and skeleton · 28C, 3week | 6 | 5 | 45.92 | 100.52 | |
| polyp and skeleton · 26C, 3week | 4 | 4 | 47.27 | 55.66 | |
| polyp and skeleton · 28C, 24hr | 2 | 2 | 44.66 | 51.19 | |
| polyp and skeleton · 31C, 24hr | 2 | 1 | 20.21 | 40.42 |
| SRA run | Condition | Tissue | Developmental stage | Treatment | Study | TPM |
|---|---|---|---|---|---|---|
| ERR6178387 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 39.81 |
| ERR6178771 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 36.35 |
| ERR6178781 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 35.17 |
| ERR6178772 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 33.49 |
| ERR6178774 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 32.68 |
| ERR6178389 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 32.06 |
| ERR6178776 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 30.50 |
| ERR6178775 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 30.10 |
| ERR6178777 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 30.00 |
| ERR6178779 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 29.95 |
| ERR6178770 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 29.81 |
| ERR6178782 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 29.05 |
| ERR6178773 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 27.60 |
| ERR6178778 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 26.70 |
| ERR6178783 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 24.58 |
| ERR6178780 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 23.00 |
| ERR6178388 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 22.81 |
| SRR12578065 | polyp and skeleton · 31C, 3week | polyp and skeleton | not recorded | 31C, 3week | SRP115860 | 53.25 |
| SRR12587804 | polyp and skeleton · 31C, 3week | polyp and skeleton | not recorded | 31C, 3week | SRP115860 | 45.96 |
| SRR12578068 | polyp and skeleton · 31C, 3week | polyp and skeleton | not recorded | 31C, 3week | SRP115860 | 38.61 |
| SRR12587800 | polyp and skeleton · 31C, 3week | polyp and skeleton | not recorded | 31C, 3week | SRP115860 | 34.88 |
| SRR12587799 | polyp and skeleton · 31C, 3week | polyp and skeleton | not recorded | 31C, 3week | SRP115860 | 34.44 |
| SRR12578066 | polyp and skeleton · 31C, 3week | polyp and skeleton | not recorded | 31C, 3week | SRP115860 | 24.42 |
| SRR12578067 | polyp and skeleton · 28C, 3week | polyp and skeleton | not recorded | 28C, 3week | SRP115860 | 100.52 |
| SRR12587802 | polyp and skeleton · 28C, 3week | polyp and skeleton | not recorded | 28C, 3week | SRP115860 | 52.84 |
| SRR12587803 | polyp and skeleton · 28C, 3week | polyp and skeleton | not recorded | 28C, 3week | SRP115860 | 41.46 |
| SRR12587808 | polyp and skeleton · 28C, 3week | polyp and skeleton | not recorded | 28C, 3week | SRP115860 | 41.36 |
| SRR12587807 | polyp and skeleton · 28C, 3week | polyp and skeleton | not recorded | 28C, 3week | SRP115860 | 39.36 |
| SRR5949849 | polyp and skeleton · 28C, 3week | polyp and skeleton | not recorded | 28C, 3week | SRP115860 | 0.00 |
| SRR12587806 | polyp and skeleton · 26C, 3week | polyp and skeleton | not recorded | 26C, 3week | SRP115860 | 55.66 |
| SRR12587801 | polyp and skeleton · 26C, 3week | polyp and skeleton | not recorded | 26C, 3week | SRP115860 | 53.02 |
| SRR12587798 | polyp and skeleton · 26C, 3week | polyp and skeleton | not recorded | 26C, 3week | SRP115860 | 43.52 |
| SRR12587805 | polyp and skeleton · 26C, 3week | polyp and skeleton | not recorded | 26C, 3week | SRP115860 | 36.86 |
| SRR5949850 | polyp and skeleton · 28C, 24hr | polyp and skeleton | not recorded | 28C, 24hr | SRP115860 | 51.19 |
| SRR12578063 | polyp and skeleton · 28C, 24hr | polyp and skeleton | not recorded | 28C, 24hr | SRP115860 | 38.13 |
| SRR12578064 | polyp and skeleton · 31C, 24hr | polyp and skeleton | not recorded | 31C, 24hr | SRP115860 | 40.42 |
| SRR5949848 | polyp and skeleton · 31C, 24hr | polyp and skeleton | not recorded | 31C, 24hr | SRP115860 | 0.00 |
Source: CnidoSite RNA-seq expression matrices (HCOER_TPM,
StringTie quantification over 37 runs), joined to SRA sample
metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped
by the descriptor carried in the expression matrix itself.
Genes whose expression across the transcriptome samples of Heliopora coerulea tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.
| Direction | Partners | Most correlated partner | PCC |
|---|---|---|---|
| Positively correlated | 15 | ENSBQFP00000018523 | 0.890971017973743 |
| Negatively correlated | 44 | ENSBQFP00000013788 | -0.744661031522884 |
Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list. Partner counts were matched on ENSBQFP00000034690, the spelling this network uses.
Whether this gene can be visualised in the single-cell atlases of Heliopora coerulea, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.
No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.
Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.
No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.
Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.
| Analysis | What it does | Status | |
|---|---|---|---|
| Primer design | Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed. | template found | open → |
| BLAST | Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start. | template found | open → |
| Expression heatmap | Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it. | ready | open → |
| Gene family / orthogroup | Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue. | open → | |
| Gene set analysis | Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it. | open → |
