Gene detail

Detailed information of ENSBQFP00000035763.1 in Heliopora coerulea

Genomic Location: JASJOG010000116.1:448732...451587
NR annotation: CAB3985886.1, DNA repair RAD51 homolog 1 [Paramuricea clavata]
Species Heliopora coerulea · all data for this species · gene families

Gene Structure

More details in JBrowse

Sequence

CDS

Protein

UniProt (Swiss-Prot top hit)

UniProt accession	Description
Q06609	DNA repair protein RAD51 homolog 1 OS=Homo sapiens OX=9606 GN=RAD51 PE=1 SV=1
P70099	DNA repair protein RAD51 homolog 1 OS=Cricetulus griseus OX=10029 GN=RAD51 PE=2 SV=1
Q91917	DNA repair protein RAD51 homolog B OS=Xenopus laevis OX=8355 GN=rad51-b PE=2 SV=1

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0001814 (this species only) · gene tree & orthology

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF14520 all species →	HHH_5	Helix-hairpin-helix domain	Domain	Interproscan
PF08423 all species →	Rad51	Rad51	Domain	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR027417 all species →	Homologous_superfamily	P-loop containing nucleoside triphosphate hydrolase	Interproscan
IPR003593 all species →	Domain	AAA+ ATPase domain	Interproscan
IPR011941 all species →	Family	DNA recombination/repair protein Rad51	Interproscan
IPR010995 all species →	Homologous_superfamily	DNA repair Rad51/transcription factor NusA, alpha-helical	Interproscan
IPR020588 all species →	Domain	DNA recombination and repair protein RecA-like, ATP-binding domain	Interproscan
IPR020587 all species →	Domain	DNA recombination and repair protein RecA, monomer-monomer interface	Interproscan
IPR016467 all species →	Family	DNA recombination and repair protein, RecA-like	Interproscan
IPR013632 all species →	Domain	DNA recombination and repair protein Rad51-like, C-terminal	Interproscan
IPR011940 all species →	Family	Meiotic recombination protein Dmc1	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR22942 all species →	RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0016887 all species →	Molecular Function	ATP hydrolysis activity	Interproscan
GO:0000150 all species →	Molecular Function	DNA strand exchange activity	Interproscan
GO:0000724 all species →	Biological Process	double-strand break repair via homologous recombination	Interproscan
GO:0003690 all species →	Molecular Function	double-stranded DNA binding	Interproscan
GO:0003697 all species →	Molecular Function	single-stranded DNA binding	Interproscan
GO:0008094 all species →	Molecular Function	ATP-dependent activity, acting on DNA	Interproscan
GO:1990426 all species →	Biological Process	mitotic recombination-dependent replication fork processing	Interproscan
GO:0000730 all species →	Biological Process	DNA recombinase assembly	Interproscan
GO:0000794 all species →	Cellular Component	condensed nuclear chromosome	Interproscan
GO:0006312 all species →	Biological Process	mitotic recombination	Interproscan
GO:0007131 all species →	Biological Process	reciprocal meiotic recombination	Interproscan
GO:0042148 all species →	Biological Process	DNA strand invasion	Interproscan
GO:0070192 all species →	Biological Process	chromosome organization involved in meiotic cell cycle	Interproscan
GO:0000166 all species →	Molecular Function	nucleotide binding	Interproscan
GO:0003677 all species →	Molecular Function	DNA binding	Interproscan
GO:0005524 all species →	Molecular Function	ATP binding	Interproscan
GO:0006281 all species →	Biological Process	DNA repair	Interproscan
GO:0140664 all species →	Molecular Function	ATP-dependent DNA damage sensor activity	Interproscan
GO:0006259 all species →	Biological Process	DNA metabolic process	Interproscan
GO:0005634 all species →	Cellular Component	nucleus	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

KO	Enzyme	Enzyme ID	Pathway	Map ID	Source
K04482	RAD51; DNA repair protein RAD51	-	DNA repair and recombination proteins	ko03400	deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Expression pattern (RNA-seq)

Transcript abundance of ENSBQFP00000035763.1 across 37 RNA-seq samples of Heliopora coerulea. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.

37Samples

30TPM > 0

6Conditions

61.6Max TPM

15.0Mean TPM

By condition

Condition	Samples	TPM > 0	Mean TPM	Max TPM
Whole coral	17	15	18.19	61.58
polyp and skeleton · 31C, 3week	6	6	17.13	34.62
polyp and skeleton · 28C, 3week	6	4	9.48	17.81
polyp and skeleton · 26C, 3week	4	2	12.02	30.48
polyp and skeleton · 28C, 24hr	2	2	10.31	11.04
polyp and skeleton · 31C, 24hr	2	1	7.86	15.72

Per sample · hover a bar for the full sample record

Show the sample table (37 samples)

SRA run	Condition	Tissue	Developmental stage	Treatment	Study	TPM
ERR6178777	Whole coral	Whole coral	not recorded	not recorded	ERP120267	61.58
ERR6178388	Whole coral	Whole coral	not recorded	not recorded	ERP120267	27.07
ERR6178387	Whole coral	Whole coral	not recorded	not recorded	ERP120267	25.77
ERR6178783	Whole coral	Whole coral	not recorded	not recorded	ERP120267	23.55
ERR6178782	Whole coral	Whole coral	not recorded	not recorded	ERP120267	21.31
ERR6178781	Whole coral	Whole coral	not recorded	not recorded	ERP120267	21.05
ERR6178389	Whole coral	Whole coral	not recorded	not recorded	ERP120267	18.68
ERR6178776	Whole coral	Whole coral	not recorded	not recorded	ERP120267	18.65
ERR6178780	Whole coral	Whole coral	not recorded	not recorded	ERP120267	17.74
ERR6178770	Whole coral	Whole coral	not recorded	not recorded	ERP120267	15.58
ERR6178779	Whole coral	Whole coral	not recorded	not recorded	ERP120267	15.43
ERR6178772	Whole coral	Whole coral	not recorded	not recorded	ERP120267	14.50
ERR6178778	Whole coral	Whole coral	not recorded	not recorded	ERP120267	11.31
ERR6178773	Whole coral	Whole coral	not recorded	not recorded	ERP120267	9.63
ERR6178774	Whole coral	Whole coral	not recorded	not recorded	ERP120267	7.31
ERR6178771	Whole coral	Whole coral	not recorded	not recorded	ERP120267	0.00
ERR6178775	Whole coral	Whole coral	not recorded	not recorded	ERP120267	0.00
SRR12578066	polyp and skeleton · 31C, 3week	polyp and skeleton	not recorded	31C, 3week	SRP115860	34.62
SRR12587800	polyp and skeleton · 31C, 3week	polyp and skeleton	not recorded	31C, 3week	SRP115860	18.91
SRR12587804	polyp and skeleton · 31C, 3week	polyp and skeleton	not recorded	31C, 3week	SRP115860	16.36
SRR12578068	polyp and skeleton · 31C, 3week	polyp and skeleton	not recorded	31C, 3week	SRP115860	12.83
SRR12578065	polyp and skeleton · 31C, 3week	polyp and skeleton	not recorded	31C, 3week	SRP115860	12.79
SRR12587799	polyp and skeleton · 31C, 3week	polyp and skeleton	not recorded	31C, 3week	SRP115860	7.24
SRR12587808	polyp and skeleton · 28C, 3week	polyp and skeleton	not recorded	28C, 3week	SRP115860	17.81
SRR12587807	polyp and skeleton · 28C, 3week	polyp and skeleton	not recorded	28C, 3week	SRP115860	15.92
SRR12587802	polyp and skeleton · 28C, 3week	polyp and skeleton	not recorded	28C, 3week	SRP115860	14.94
SRR12587803	polyp and skeleton · 28C, 3week	polyp and skeleton	not recorded	28C, 3week	SRP115860	8.24
SRR12578067	polyp and skeleton · 28C, 3week	polyp and skeleton	not recorded	28C, 3week	SRP115860	0.00
SRR5949849	polyp and skeleton · 28C, 3week	polyp and skeleton	not recorded	28C, 3week	SRP115860	0.00
SRR12587805	polyp and skeleton · 26C, 3week	polyp and skeleton	not recorded	26C, 3week	SRP115860	30.48
SRR12587798	polyp and skeleton · 26C, 3week	polyp and skeleton	not recorded	26C, 3week	SRP115860	17.61
SRR12587801	polyp and skeleton · 26C, 3week	polyp and skeleton	not recorded	26C, 3week	SRP115860	0.00
SRR12587806	polyp and skeleton · 26C, 3week	polyp and skeleton	not recorded	26C, 3week	SRP115860	0.00
SRR12578063	polyp and skeleton · 28C, 24hr	polyp and skeleton	not recorded	28C, 24hr	SRP115860	11.04
SRR5949850	polyp and skeleton · 28C, 24hr	polyp and skeleton	not recorded	28C, 24hr	SRP115860	9.58
SRR12578064	polyp and skeleton · 31C, 24hr	polyp and skeleton	not recorded	31C, 24hr	SRP115860	15.72
SRR5949848	polyp and skeleton · 31C, 24hr	polyp and skeleton	not recorded	31C, 24hr	SRP115860	0.00

Source: CnidoSite RNA-seq expression matrices (HCOER_TPM, StringTie quantification over 37 runs), joined to SRA sample metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped by the descriptor carried in the expression matrix itself.

Co-expression network

Genes whose expression across the transcriptome samples of Heliopora coerulea tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

Direction	Partners	Most correlated partner	PCC
Positively correlated	24	ENSBQFP00000043407	0.851676630047079
Negatively correlated	3	ENSBQFP00000020519	-0.593195230578871

Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list. Partner counts were matched on ENSBQFP00000035763, the spelling this network uses.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Heliopora coerulea, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

Analysis	What it does	Status
Primer design	Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.	template found	open →
BLAST	Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.	template found	open →
Expression heatmap	Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.	ready	open →
Gene family / orthogroup	Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.		open →
Gene set analysis	Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.		open →