Genomic Location: JASJOG010000208.1:479720...489970
NR annotation: CAB4026147.1, guanylate cyclase soluble subunit beta-1 isoform X1, partial [Paramuricea clavata]
Species Heliopora coerulea · all data for this species · gene families
| CDS |
| ENSBQFT00000047962 |
| Protein |
| ENSBQFP00000042626.1 |
| UniProt accession | Description |
|---|---|
| P16068 | Guanylate cyclase soluble subunit beta-1 OS=Bos taurus OX=9913 GN=GUCY1B1 PE=1 SV=1 |
| O54865 | Guanylate cyclase soluble subunit beta-1 OS=Mus musculus OX=10090 GN=Gucy1b1 PE=1 SV=1 |
| Q02153 | Guanylate cyclase soluble subunit beta-1 OS=Homo sapiens OX=9606 GN=GUCY1B1 PE=1 SV=1 |
| Family type | Membership / link |
|---|---|
| Orthogroup (gene family) | OG0001299 (this species only) · gene tree & orthology |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF00211 all species → | Guanylate_cyc | Adenylate and Guanylate cyclase catalytic domain | Domain | Interproscan |
| PF07701 all species → | HNOBA | Heme NO binding associated | Domain | Interproscan |
| PF07700 all species → | HNOB | Haem-NO-binding | Domain | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR001054 all species → | Domain | Adenylyl cyclase class-3/4/guanylyl cyclase | Interproscan |
| IPR011645 all species → | Domain | Haem NO binding associated | Interproscan |
| IPR011644 all species → | Domain | Heme NO-binding | Interproscan |
| IPR024096 all species → | Homologous_superfamily | NO signalling/Golgi transport ligand-binding domain superfamily | Interproscan |
| IPR029787 all species → | Homologous_superfamily | Nucleotide cyclase | Interproscan |
| IPR042463 all species → | Homologous_superfamily | Haem NO binding associated domain superfamily | Interproscan |
| IPR038158 all species → | Homologous_superfamily | H-NOX domain superfamily | Interproscan |
| IPR018297 all species → | Conserved_site | Adenylyl cyclase class-4/guanylyl cyclase, conserved site | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR45655 all species → | GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2 | Interproscan |
| GO term | Category | Description | Source |
|---|---|---|---|
| GO:0009190 all species → | Biological Process | cyclic nucleotide biosynthetic process | Interproscan |
| GO:0035556 all species → | Biological Process | intracellular signal transduction | Interproscan |
| GO:0004383 all species → | Molecular Function | guanylate cyclase activity | Interproscan |
| GO:0006182 all species → | Biological Process | cGMP biosynthetic process | Interproscan |
| GO:0008074 all species → | Cellular Component | guanylate cyclase complex, soluble | Interproscan |
| GO:0019934 all species → | Biological Process | cGMP-mediated signaling | Interproscan |
| GO:0070482 all species → | Biological Process | response to oxygen levels | Interproscan |
| GO:0020037 all species → | Molecular Function | heme binding | Interproscan |
| GO:0016849 all species → | Molecular Function | phosphorus-oxygen lyase activity | Interproscan |
| KO | Enzyme | Enzyme ID | Pathway | Map ID | Source |
|---|---|---|---|---|---|
| K12319 | GUCY1B; guanylate cyclase soluble subunit beta | EC:4.6.1.2 | Circadian entrainment | ko04713 | deepkoala |
Transcript abundance of ENSBQFP00000042626.1 across 37 RNA-seq samples of Heliopora coerulea. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.
| Condition | Samples | TPM > 0 | Mean TPM | Max TPM | Mean, relative to max |
|---|---|---|---|---|---|
| Whole coral | 17 | 10 | 0.87 | 4.31 | |
| polyp and skeleton · 31C, 3week | 6 | 6 | 10.37 | 16.00 | |
| polyp and skeleton · 28C, 3week | 6 | 4 | 8.54 | 19.13 | |
| polyp and skeleton · 26C, 3week | 4 | 3 | 7.29 | 16.58 | |
| polyp and skeleton · 28C, 24hr | 2 | 2 | 15.93 | 16.63 | |
| polyp and skeleton · 31C, 24hr | 2 | 1 | 2.12 | 4.24 |
| SRA run | Condition | Tissue | Developmental stage | Treatment | Study | TPM |
|---|---|---|---|---|---|---|
| ERR6178773 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 4.31 |
| ERR6178780 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 2.42 |
| ERR6178389 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 2.04 |
| ERR6178778 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 1.51 |
| ERR6178774 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 1.13 |
| ERR6178781 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 0.86 |
| ERR6178779 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 0.80 |
| ERR6178770 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 0.80 |
| ERR6178776 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 0.68 |
| ERR6178783 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 0.27 |
| ERR6178387 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 0.00 |
| ERR6178388 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 0.00 |
| ERR6178771 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 0.00 |
| ERR6178772 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 0.00 |
| ERR6178775 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 0.00 |
| ERR6178777 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 0.00 |
| ERR6178782 | Whole coral | Whole coral | not recorded | not recorded | ERP120267 | 0.00 |
| SRR12578068 | polyp and skeleton · 31C, 3week | polyp and skeleton | not recorded | 31C, 3week | SRP115860 | 16.00 |
| SRR12587800 | polyp and skeleton · 31C, 3week | polyp and skeleton | not recorded | 31C, 3week | SRP115860 | 15.32 |
| SRR12587804 | polyp and skeleton · 31C, 3week | polyp and skeleton | not recorded | 31C, 3week | SRP115860 | 11.07 |
| SRR12578065 | polyp and skeleton · 31C, 3week | polyp and skeleton | not recorded | 31C, 3week | SRP115860 | 7.74 |
| SRR12578066 | polyp and skeleton · 31C, 3week | polyp and skeleton | not recorded | 31C, 3week | SRP115860 | 7.37 |
| SRR12587799 | polyp and skeleton · 31C, 3week | polyp and skeleton | not recorded | 31C, 3week | SRP115860 | 4.74 |
| SRR12587802 | polyp and skeleton · 28C, 3week | polyp and skeleton | not recorded | 28C, 3week | SRP115860 | 19.13 |
| SRR12587807 | polyp and skeleton · 28C, 3week | polyp and skeleton | not recorded | 28C, 3week | SRP115860 | 14.19 |
| SRR12587803 | polyp and skeleton · 28C, 3week | polyp and skeleton | not recorded | 28C, 3week | SRP115860 | 10.60 |
| SRR12587808 | polyp and skeleton · 28C, 3week | polyp and skeleton | not recorded | 28C, 3week | SRP115860 | 7.33 |
| SRR12578067 | polyp and skeleton · 28C, 3week | polyp and skeleton | not recorded | 28C, 3week | SRP115860 | 0.00 |
| SRR5949849 | polyp and skeleton · 28C, 3week | polyp and skeleton | not recorded | 28C, 3week | SRP115860 | 0.00 |
| SRR12587806 | polyp and skeleton · 26C, 3week | polyp and skeleton | not recorded | 26C, 3week | SRP115860 | 16.58 |
| SRR12587798 | polyp and skeleton · 26C, 3week | polyp and skeleton | not recorded | 26C, 3week | SRP115860 | 6.57 |
| SRR12587805 | polyp and skeleton · 26C, 3week | polyp and skeleton | not recorded | 26C, 3week | SRP115860 | 5.99 |
| SRR12587801 | polyp and skeleton · 26C, 3week | polyp and skeleton | not recorded | 26C, 3week | SRP115860 | 0.00 |
| SRR12578063 | polyp and skeleton · 28C, 24hr | polyp and skeleton | not recorded | 28C, 24hr | SRP115860 | 16.63 |
| SRR5949850 | polyp and skeleton · 28C, 24hr | polyp and skeleton | not recorded | 28C, 24hr | SRP115860 | 15.23 |
| SRR12578064 | polyp and skeleton · 31C, 24hr | polyp and skeleton | not recorded | 31C, 24hr | SRP115860 | 4.24 |
| SRR5949848 | polyp and skeleton · 31C, 24hr | polyp and skeleton | not recorded | 31C, 24hr | SRP115860 | 0.00 |
Source: CnidoSite RNA-seq expression matrices (HCOER_TPM,
StringTie quantification over 37 runs), joined to SRA sample
metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped
by the descriptor carried in the expression matrix itself.
Genes whose expression across the transcriptome samples of Heliopora coerulea tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.
| Direction | Partners | Most correlated partner | PCC |
|---|---|---|---|
| Positively correlated | 17 | ENSBQFP00000044194 | 0.868560752082332 |
| Negatively correlated | 9 | ENSBQFP00000038192 | -0.743873531835539 |
Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list. Partner counts were matched on ENSBQFP00000042626, the spelling this network uses.
Whether this gene can be visualised in the single-cell atlases of Heliopora coerulea, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.
No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.
Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.
No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.
Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.
| Analysis | What it does | Status | |
|---|---|---|---|
| Primer design | Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed. | template found | open → |
| BLAST | Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start. | template found | open → |
| Expression heatmap | Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it. | ready | open → |
| Gene family / orthogroup | Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue. | open → | |
| Gene set analysis | Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it. | open → |
