Gene detail

Detailed information of ENSDLIP00000005378.1 in Diadumene lineata

Genomic Location: chr1:11831927...11845470
NR annotation: XP_020902563.1, regulator of G-protein signaling 7 isoform X1 [Exaiptasia diaphana]
Species Diadumene lineata · all data for this species · gene families

Gene Structure

More details in JBrowse

Sequence

CDS

Transcript

ENSDLIT00000005825

TTTACACCCAGCTAGTTTTATCAGTCAGCTGTATTCGATACTTTGATTTATCCTGTGAAAGGCTGATTATTTGGTTTGGTTTATCAACGAATGGGTTGTGTCTCAATCCGAGTTCAAGTCAAACTATTTACCATTTGCCTGTTTTGACATGATTAcaagtattttgtatttactttTTTGCCGACGCTCCTAGAGAACAGCATTGTGAAATCTTTTAGACGCCATGGCTCATTCACTAAGGAATTCTATGAACATAAAATAAGTTAGAAGGAAGTGAACGAAAATTTGCGATTGTGAAGATGAAGAACGAGGAAGGTGATCACGAAGAACCACCACATTCGCTGGTTTGCAGCAAGaTGGAGAAAATCATTCAAATGATGCAAGATGAAAAGAATGGTGTTGCAATTAGAACAGTTAAAAGCTTTATGTCAAAGATACCAAGTGTATTAACAGGATCAGAGCTTATTGACTGGATGGTAGAAAACCTTGGAATCGAAGACAGAGGGGAGGGTGTTCATCTAGCATCTCTTCTAGCTGCCTATGGATATGTGTTCTCAATAACTGACCATCACCTAATGGTTAAAGATGATGGTTCATATTACAGATTCCAGACACCCTACTTTTGGTTGTCAAATAACTGGGAACCAGAAAATATCGACTATGctGTTTATCTATGCAAAAGGACAATGCAAAATAAATCAAGACTGGAATTAGATGATTATGAAGCTGAAAATTTAGCCAAGTTGCAAAGAACGCTATCAAGAAAGTGGGAGTTTATATTCATGCAAGCCGAGGCACAAGCTAAAGTTGACAAGAAACGAGATAAAATGGAAAGACAAATCCTTGATAGCCAAGAAAGAGCATTTTGGAATGTCCATAGACCTCCACCTGGTTGTGTATCAGTCACTGAAGTGGACATCAAGAAAGCATGCAAAACGGATGTTTCTCCAAACACCAGAAGAAAAGCCAAGCTGTTTCACACTGGGATGTCACCATTAGAAAACTCTTCtccttcatcatcatttactGCTCTTGATGAAATGAGATGTGAGgTTCAAGAACTTAAAGAATTACTTCATAGAAGAAGAATGAAAACATCACAGGCTTCAGAGAATTTAATTCATAGATATGAACAATATGCAGAATATGATTCATTCATATCCTGTCCCGAGCCATCTAATCCATGGATAACAGATGATATTACGCTATGGGAGCAGGACAAATCATTtttttactttttaaggCAATATGTACCTCCAAAGAGAGTCAAGAGATGGGGATTCTCATTGTCTGAACTGCTACAGGACCCACTAGGACGAAGACACTTCACACGATTTCTTGAAAAGGAATTTAGTGCTGAGAATTTAGGGTTCTGGTTAGCTTGTGAACAGCTCAAAGCTACACCTGCCAAACATGTACCTGAAaaagcatatgatattttcaaTGAATACTTATCAAAAGAAGCCACATCACCAATTAATGTGGATTGTAAGACACACGAAGAGGTAGAGCTCAATCTCAAGAAACCAGGTCGATATATGTTTGATGCTGCTCAAGATCATATATTCCAGCTGATGAAATCAGACAGCTATAGTCGATTTTTACGCAGTGAACAATATAAAGAACTTTTAAAGGCTCCTGCCTTCAAACAAAGAAGCCCTCTTCCGACTCGACCACTGCAGAATCTAGCTCGTATAGCAGGCTCTAGAACTTGAAGATTGTAGAGAATGTGAAtaatttctgaaaaaaatgattttttaattattatttttgattatttaataattgatcAAACTAATATTACCACCAAGATAATaggtattttttaattttgtttgttgtcttCAAAAAGTGAAAGGCAAGATTTGACCcactttttattaaaaaaaaattggtgatcttgaagaaaataattcctagcaaccaatcaaaatgctAGAGTAATATTAGTcaatgcaatatttattacaattattgaaTTAGAGATTGGAATAAGATTTCTTATTTAGCAAGAGAATACTATGTATTCTCcatttattatcatcaacatgtATCCAGAAAGGGTGAGGCAAGATTGGaagttttgtttcaaaacatttttgtgaaGATTCACCCTTCTGGCTGTGGCACATGGTGAGCAAATTGTAATTTTGTGCACTTTGTCTCATTGCAAAGGCAAAGAATTCAATATATGCTTATAAAACTCATTAGTAATTCATAaggcaaaaataatgaaaatcacgacccatgaaggcatctgtaaatcagATACAGTTTTGCCCTGATTTGCACAAAGTTGAACCTTTATTTTCTCATAATCAAATGGAGATATTTTCACTTGTACTATATTGGGAGTCTCATAAATTTTGTCGTTCTTCAGGTCTTGTGAGGTAGTGCCACAGTTTTATATCCCATTTTTGCCTTTCTGAGACTtgacaaatgacaaaatttaTCCGCACACACTGAATATTTTGCCTTACGAGGCAGAGGCATAATGCACCTATGACAATTTGCTCAGTGTGCGTTTAAcacatattttatttgatttctatACTCAGTCAATGTCAAACTCTTTTTGTCTTATAGTGCTTCTCAGACTTTACTTTCCCTAAATTGACACTTTTATGGGTCTTTATAATACCTTTGGTACAATGCTGATTTCTGATTTTGATAGGGAGAGAAACGGGGTACTTCCTTTCACCTCTGAAATCATG

Protein

UniProt (Swiss-Prot top hit)

UniProt accession	Description
O46470	Regulator of G-protein signaling 7 OS=Bos taurus OX=9913 GN=RGS7 PE=1 SV=1
P49803	Regulator of G-protein signaling 7 OS=Rattus norvegicus OX=10116 GN=Rgs7 PE=1 SV=2
P49802	Regulator of G-protein signaling 7 OS=Homo sapiens OX=9606 GN=RGS7 PE=1 SV=3

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0004228 (this species only) · gene tree & orthology

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF00615 all species →	RGS	Regulator of G protein signaling domain	Domain	Interproscan
PF18148 all species →	RGS_DHEX	Regulator of G-protein signalling DHEX domain	Domain	Interproscan
PF00610 all species →	DEP	Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)	Domain	Interproscan
PF00631 all species →	G-gamma	GGL domain	Domain	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR036284 all species →	Homologous_superfamily	G-protein gamma-like domain superfamily	Interproscan
IPR016137 all species →	Domain	RGS domain	Interproscan
IPR047016 all species →	Family	Regulator of G protein signaling 6/7/9/11	Interproscan
IPR040759 all species →	Domain	Regulator of G-protein signalling, DHEX domain	Interproscan
IPR015898 all species →	Domain	G-protein gamma-like domain	Interproscan
IPR000591 all species →	Domain	DEP domain	Interproscan
IPR034483 all species →	Domain	Regulator of G-protein signalling Egl-10, RGS domain	Interproscan
IPR044926 all species →	Homologous_superfamily	RGS, subdomain 2	Interproscan
IPR036388 all species →	Homologous_superfamily	Winged helix-like DNA-binding domain superfamily	Interproscan
IPR036390 all species →	Homologous_superfamily	Winged helix DNA-binding domain superfamily	Interproscan
IPR047017 all species →	Homologous_superfamily	Regulator of G-protein signalling 6/7/9/11, DHEX domain superfamily	Interproscan
IPR036305 all species →	Homologous_superfamily	RGS domain superfamily	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR45746 all species →	LP21163P	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0007186 all species →	Biological Process	G protein-coupled receptor signaling pathway	Interproscan
GO:0005096 all species →	Molecular Function	GTPase activator activity	Interproscan
GO:0005737 all species →	Cellular Component	cytoplasm	Interproscan
GO:0008277 all species →	Biological Process	regulation of G protein-coupled receptor signaling pathway	Interproscan
GO:0043547 all species →	Biological Process	positive regulation of GTPase activity	Interproscan
GO:0035556 all species →	Biological Process	intracellular signal transduction	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

KO	Enzyme	Enzyme ID	Pathway	Map ID	Source
K16449	RGS; regulator of G-protein signaling	-	Signaling proteins	-	deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Co-expression network

Genes whose expression across the transcriptome samples of Diadumene lineata tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

No co-expression network has been built for this species, so this gene has no partners to show. Networks are available for the species listed on the Network Analysis page.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Diadumene lineata, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

Analysis	What it does	Status
Primer design	Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.	template found	open →
BLAST	Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.	template found	open →
Expression heatmap	Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.	no expression matrix	–
Gene family / orthogroup	Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.		open →
Gene set analysis	Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.		open →