Gene detail

Detailed information of ENSDLIP00000013908.1 in Diadumene lineata

Genomic Location: chr15:1799335...1805863
NR annotation: XP_020892524.1, NADP-dependent malic enzyme [Exaiptasia diaphana]
Species Diadumene lineata · all data for this species · gene families

Gene Structure

More details in JBrowse

Sequence

CDS

Transcript

ENSDLIT00000015308

CTTCCTCCAGGTAAAATCATGTGCAAAAACATGCTTTTGTAATTTAAGAAGCTCAAAGTTTTGTTAAAGATTAACTTTTGTTTGCACTGACTAAGAGCATAGTTACTCCTATAACAATTAAACCATGATTTAATTCTTTGTCAGCGTGACTGCAGTCAACCGTTTGCAAGTACACCCGAGAACAATCGTTCCAGTAGCTTTATTCAGCATGTCAGAGCCGAAAAGAGTGAATAAAATCCCTACAATTCGAGGGGCTGATATTATGCGAGATGCAAGCCTGAATAAGGTATATTCAACTCATGGCATTATTGGAGAGGAATCAAGCCCTGTTCTTCAGAGTACTGTTTGATCACACACAAGAAATTATGCCAATAGTTTACACTCCAACAGTTGGCCTTGCTTGTCAGAAATATGGCATGATATTCAGAGGTTCACGAGGGCTCTTCATCTCTATTAACGACCTGGGGCATGTTGATGAAATTGTCTCAAACTGGCCTGTCCAAAATGTCAAGGCAATAGTGATGACAGATGGTGAGCGTATTCTTGGTCTGGGAGATCTTGGTTGCTGTGGTATGGGGATTCCTGTTGGTAAACTGTGTTTGTATACCGTATGTGGTGGTATTGATCCTAACGTCTGTCTACCAGTCATGATTGATGTGGGCACCAATAATCAGAAACTTCTTGATGACCCGTTCTACATTGGAGTTCGCCAGAAGAGAGACAACAGTGAAAGATATGATCAGCTTATTGATGAATTCATCAAAGCTGCTTTGCAGAGATTTGGGCCAACTACTCTTATCCAGTTTGAAGACTTTGGTAACCACAATGCCTTCAGGTTCTTGGAGAAATATCGTAATAAGATATGTACATTTAATGATGACATTCAAGGTACTGCTGCAGTAGCTGTTGCTGGAATCCTGGCTTCTCTGAAAATCACACATACAAAACTGGCAGACCAAAAGATACTCTTCCAGGGAGCTGGAGAGGCTGCAATCGGTATTGCCAACCTATTGGTTCTTGCAATGAAGAAAGAGGGTCTATCAGAAGAGGAAGCTAAGAGTAAAATATGGCTGGTGGATTCTAAAGGTCTTATTGTCAAGAATCGTTCTGTTGGAGGTTTGAATGACCAGAAACTGATTTATGCAAAGGAAGCCGAATACATTGATAATTTAACTGATGTTGTTAAAACGATCAAACCAACTGCAATTGTAGgGGTTGCTGCTGTCCCTGGTGCTTTTACAGAAGAGATCTGCAAGGAGATGGCGTCTTTCAATAAAAGACCTATTATCTTTGCATTGAGTAATCCTACATCCCAAGCAGAATGTAAAGCTGAAGAGGCCTACACATGGACAGACGGTAAAGCGATATTTGCAAGTGGAAGTCCATTTGACCCAGTCACCCTCCCAGATGGTCGTCACTTTGTACCTGGCCAGGGTAACAATTCTTATATATTTCCTGGTCTAGCTCTTGGGGTGATAGCATGCGAGGCTTGTCATGTTACTGATGGTATGTTCTTGAAAGCTGCAGAGTCTCTTGCTGACCAAGTCCATCAGTCACAGCTAGATAGTGGTTGCCTTTATCCTCCTCTTGGTGAAATAAGAGATGTGTCCTTCAAGATCGCTATTGATGTGGTAGAGACTGCTTATGCTGAGCGTGTTGCAACTGAACTACCAGAACCAGAAGACAAAGAGGAACTTGTGAGAAATCATCTTTACGAACCCAGCTATATGTCATATATTCCCAAGACATATCCTTGGCCAGAACagaaatgaattgatttaacacgaatgaatgaataaatagaggAGCGAACTTTTGACGCAAGTTGACTTATTTGTGGTTGCTAGGTTAATCattataaatcaataaaaaaatcaatttttttgcagttttctAAGTTTCACTAAgtatatatatgagtcgtgaaaacttaaattgggtctagctggcgaagacccctttgatgcacatctttttcgtttttcacttttctttctttcgaagttgatgtttctcagttcagaaacccttagaccctatttaagtaGTCAcaactcatatatatatatatatatatatatatatatatatatatgtgtatatatatcaTAAATGAATTCAATTTTCGATAATACTTATATCTATCTTGATTGTGATTTAGTGTAAATCTACACTAAATAGAGGCGTGTGATTCCTCAagagaaataaatcaaatgaaaaa

Protein

UniProt (Swiss-Prot top hit)

UniProt accession	Description
P13697	NADP-dependent malic enzyme OS=Rattus norvegicus OX=10116 GN=Me1 PE=1 SV=2
P06801	NADP-dependent malic enzyme OS=Mus musculus OX=10090 GN=Me1 PE=1 SV=2
P48163	NADP-dependent malic enzyme OS=Homo sapiens OX=9606 GN=ME1 PE=1 SV=1

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0003926 (this species only) · gene tree & orthology

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF03949 all species →	Malic_M	Malic enzyme, NAD binding domain	Domain	Interproscan
PF00390 all species →	malic	Malic enzyme, N-terminal domain	Domain	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR001891 all species →	Family	Malic oxidoreductase	Interproscan
IPR012302 all species →	Domain	Malic enzyme, NAD-binding	Interproscan
IPR036291 all species →	Homologous_superfamily	NAD(P)-binding domain superfamily	Interproscan
IPR012301 all species →	Domain	Malic enzyme, N-terminal domain	Interproscan
IPR015884 all species →	Conserved_site	Malic enzyme, conserved site	Interproscan
IPR037062 all species →	Homologous_superfamily	Malic enzyme, N-terminal domain superfamily	Interproscan
IPR046346 all species →	Homologous_superfamily	Aminoacid dehydrogenase-like, N-terminal domain superfamily	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR23406 all species →	MALIC ENZYME-RELATED	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0004470 all species →	Molecular Function	malic enzyme activity	Interproscan
GO:0016616 all species →	Molecular Function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Interproscan
GO:0051287 all species →	Molecular Function	NAD binding	Interproscan
GO:0004473 all species →	Molecular Function	malate dehydrogenase (decarboxylating) (NADP+) activity	Interproscan
GO:0005739 all species →	Cellular Component	mitochondrion	Interproscan
GO:0006090 all species →	Biological Process	pyruvate metabolic process	Interproscan
GO:0006108 all species →	Biological Process	malate metabolic process	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

KO	Enzyme	Enzyme ID	Pathway	Map ID	Source
K00029	maeB; malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+)	EC:1.1.1.40	PPAR signaling pathway	ko03320	deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Co-expression network

Genes whose expression across the transcriptome samples of Diadumene lineata tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

No co-expression network has been built for this species, so this gene has no partners to show. Networks are available for the species listed on the Network Analysis page.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Diadumene lineata, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

Analysis	What it does	Status
Primer design	Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.	template found	open →
BLAST	Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.	template found	open →
Expression heatmap	Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.	no expression matrix	–
Gene family / orthogroup	Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.		open →
Gene set analysis	Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.		open →