Detailed information of ENSDLIP00000015203.1 in Diadumene lineata

Genomic Location: chr2:20013696...20026796
NR annotation: XP_020893591.1, DNA replication ATP-dependent helicase/nuclease DNA2-like [Exaiptasia diaphana]
Species Diadumene lineata · all data for this species · gene families


 Gene Structure
More details in JBrowse  Sequence
CDS
Transcript
Protein
 UniProt (Swiss-Prot top hit)
UniProt accessionDescription
Q8QHA5DNA replication ATP-dependent helicase/nuclease DNA2 OS=Xenopus laevis OX=8355 GN=dna2 PE=1 SV=1
D3ZG52DNA replication ATP-dependent helicase/nuclease DNA2 OS=Rattus norvegicus OX=10116 GN=Dna2 PE=3 SV=1
Q6ZQJ5DNA replication ATP-dependent helicase/nuclease DNA2 OS=Mus musculus OX=10090 GN=Dna2 PE=1 SV=2
 Gene family
Family typeMembership / link
Orthogroup (gene family)OG0003039 (this species only) · gene tree & orthology

 Pfam domain
Pfam accessionPfam nameDescriptionTypeSource
PF13087
all species →
AAA_12AAA domainDomainInterproscan
PF13086
all species →
AAA_11AAA domainDomainInterproscan
PF08696
all species →
Dna2DNA replication factor Dna2FamilyInterproscan

 InterPro
InterPro termTypeDescriptionSource
IPR027417
all species →
Homologous_superfamilyP-loop containing nucleoside triphosphate hydrolaseInterproscan
IPR026851
all species →
DomainDNA replication ATP-dependent helicase/nuclease Dna2/JHS1, DEXXQ-box helicase domainInterproscan
IPR041679
all species →
DomainDNA2/NAM7 helicase-like, C-terminalInterproscan
IPR047187
all species →
DomainUpf1-like, C-terminal helicase domainInterproscan
IPR041677
all species →
DomainDNA2/NAM7 helicase, helicase domainInterproscan
IPR014808
all species →
DomainDNA replication factor Dna2, N-terminalInterproscan
IPR011604
all species →
Homologous_superfamilyPD-(D/E)XK endonuclease-like domain superfamilyInterproscan
IPR045055
all species →
FamilyDNA2/NAM7-like helicaseInterproscan

 PANTHER
PANTHER termDescriptionSource
PTHR10887
all species →
DNA2/NAM7 HELICASE FAMILYInterproscan

 Gene Ontology
GO termCategoryDescriptionSource
GO:0017116
all species →
Molecular Functionsingle-stranded DNA helicase activityInterproscan
GO:0004386
all species →
Molecular Functionhelicase activityInterproscan
GO:0005737
all species →
Cellular ComponentcytoplasmInterproscan
GO:0017108
all species →
Molecular Function5'-flap endonuclease activityInterproscan
GO:0071932
all species →
Biological Processreplication fork reversalInterproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.
 KEGG pathway
KOEnzymeEnzyme IDPathwayMap IDSource
K10742DNA2; DNA replication ATP-dependent helicase/nuclease Dna2EC:5.6.2.3
EC:3.1.-.-
DNA replication proteinsko03032deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Co-expression network

Genes whose expression across the transcriptome samples of Diadumene lineata tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

No co-expression network has been built for this species, so this gene has no partners to show. Networks are available for the species listed on the Network Analysis page.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Diadumene lineata, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

AnalysisWhat it doesStatus
Primer designDesign PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.template foundopen →
BLASTSearch this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.template foundopen →
Expression heatmapDraw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.no expression matrix
Gene family / orthogroupLook this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.open →
Gene set analysisStart a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.open →
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