Genomic Location: chr2:20013696...20026796
NR annotation: XP_020893591.1, DNA replication ATP-dependent helicase/nuclease DNA2-like [Exaiptasia diaphana]
Species Diadumene lineata · all data for this species · gene families
| CDS |
| ENSDLIT00000016670 |
| Transcript |
| ENSDLIT00000016670 |
| Protein |
| ENSDLIP00000015203.1 |
| UniProt accession | Description |
|---|---|
| Q8QHA5 | DNA replication ATP-dependent helicase/nuclease DNA2 OS=Xenopus laevis OX=8355 GN=dna2 PE=1 SV=1 |
| D3ZG52 | DNA replication ATP-dependent helicase/nuclease DNA2 OS=Rattus norvegicus OX=10116 GN=Dna2 PE=3 SV=1 |
| Q6ZQJ5 | DNA replication ATP-dependent helicase/nuclease DNA2 OS=Mus musculus OX=10090 GN=Dna2 PE=1 SV=2 |
| Family type | Membership / link |
|---|---|
| Orthogroup (gene family) | OG0003039 (this species only) · gene tree & orthology |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF13087 all species → | AAA_12 | AAA domain | Domain | Interproscan |
| PF13086 all species → | AAA_11 | AAA domain | Domain | Interproscan |
| PF08696 all species → | Dna2 | DNA replication factor Dna2 | Family | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR027417 all species → | Homologous_superfamily | P-loop containing nucleoside triphosphate hydrolase | Interproscan |
| IPR026851 all species → | Domain | DNA replication ATP-dependent helicase/nuclease Dna2/JHS1, DEXXQ-box helicase domain | Interproscan |
| IPR041679 all species → | Domain | DNA2/NAM7 helicase-like, C-terminal | Interproscan |
| IPR047187 all species → | Domain | Upf1-like, C-terminal helicase domain | Interproscan |
| IPR041677 all species → | Domain | DNA2/NAM7 helicase, helicase domain | Interproscan |
| IPR014808 all species → | Domain | DNA replication factor Dna2, N-terminal | Interproscan |
| IPR011604 all species → | Homologous_superfamily | PD-(D/E)XK endonuclease-like domain superfamily | Interproscan |
| IPR045055 all species → | Family | DNA2/NAM7-like helicase | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR10887 all species → | DNA2/NAM7 HELICASE FAMILY | Interproscan |
| GO term | Category | Description | Source |
|---|---|---|---|
| GO:0017116 all species → | Molecular Function | single-stranded DNA helicase activity | Interproscan |
| GO:0004386 all species → | Molecular Function | helicase activity | Interproscan |
| GO:0005737 all species → | Cellular Component | cytoplasm | Interproscan |
| GO:0017108 all species → | Molecular Function | 5'-flap endonuclease activity | Interproscan |
| GO:0071932 all species → | Biological Process | replication fork reversal | Interproscan |
| KO | Enzyme | Enzyme ID | Pathway | Map ID | Source |
|---|---|---|---|---|---|
| K10742 | DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 | EC:5.6.2.3 EC:3.1.-.- | DNA replication proteins | ko03032 | deepkoala |
Genes whose expression across the transcriptome samples of Diadumene lineata tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.
No co-expression network has been built for this species, so this gene has no partners to show. Networks are available for the species listed on the Network Analysis page.
Whether this gene can be visualised in the single-cell atlases of Diadumene lineata, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.
No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.
Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.
No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.
Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.
| Analysis | What it does | Status | |
|---|---|---|---|
| Primer design | Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed. | template found | open → |
| BLAST | Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start. | template found | open → |
| Expression heatmap | Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it. | no expression matrix | – |
| Gene family / orthogroup | Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue. | open → | |
| Gene set analysis | Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it. | open → |