Genomic Location: chr4:16263475...16269234
NR annotation: XP_020900056.1, derlin-1 [Exaiptasia diaphana]
Species Diadumene lineata · all data for this species · gene families
| CDS |
| ENSDLIT00000024993 |
| Transcript |
| ENSDLIT00000024993 |
| Protein |
| ENSDLIP00000022621.1 |
| UniProt accession | Description |
|---|---|
| Q9BUN8 | Derlin-1 OS=Homo sapiens OX=9606 GN=DERL1 PE=1 SV=1 |
| Q5R9W3 | Derlin-1 OS=Pongo abelii OX=9601 GN=DERL1 PE=2 SV=1 |
| Q71SS4 | Derlin-1 OS=Bos taurus OX=9913 GN=DERL1 PE=2 SV=1 |
| Family type | Membership / link |
|---|---|
| Orthogroup (gene family) | OG0008125 (this species only) · gene tree & orthology |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF04511 all species → | DER1 | Der1-like family | Family | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR007599 all species → | Family | Derlin | Interproscan |
| IPR035952 all species → | Homologous_superfamily | Rhomboid-like superfamily | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR11009 all species → | DER1-LIKE PROTEIN, DERLIN | Interproscan |
| GO term | Category | Description | Source |
|---|---|---|---|
| GO:0000839 all species → | Cellular Component | Hrd1p ubiquitin ligase ERAD-L complex | Interproscan |
| GO:0030176 all species → | Cellular Component | obsolete integral component of endoplasmic reticulum membrane | Interproscan |
| GO:0030433 all species → | Biological Process | obsolete ubiquitin-dependent ERAD pathway | Interproscan |
| GO:0030968 all species → | Biological Process | endoplasmic reticulum unfolded protein response | Interproscan |
| GO:0051787 all species → | Molecular Function | misfolded protein binding | Interproscan |
| GO:1990381 all species → | Molecular Function | ubiquitin-specific protease binding | Interproscan |
| KO | Enzyme | Enzyme ID | Pathway | Map ID | Source |
|---|---|---|---|---|---|
| K11519 | DERL1; Derlin-1 | - | Pathways of neurodegeneration - multiple diseases | ko05022 | deepkoala |
Genes whose expression across the transcriptome samples of Diadumene lineata tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.
No co-expression network has been built for this species, so this gene has no partners to show. Networks are available for the species listed on the Network Analysis page.
Whether this gene can be visualised in the single-cell atlases of Diadumene lineata, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.
No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.
Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.
No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.
Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.
| Analysis | What it does | Status | |
|---|---|---|---|
| Primer design | Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed. | template found | open → |
| BLAST | Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start. | template found | open → |
| Expression heatmap | Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it. | no expression matrix | – |
| Gene family / orthogroup | Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue. | open → | |
| Gene set analysis | Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it. | open → |
