Genomic Location: chr17:440885...443251
NR annotation: CAB4004026.1, hydroxymethylglutaryl- lyase, mitochondrial [Paramuricea clavata]
Species Eunicella cavolini · all data for this species · gene families
| CDS |
| ENSLDHT00000019745 |
| Protein |
| ENSLDHP00000018058.1 |
| UniProt accession | Description |
|---|---|
| A8WG57 | 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic OS=Danio rerio OX=7955 GN=hmgcll1 PE=2 SV=1 |
| Q29448 | Hydroxymethylglutaryl-CoA lyase, mitochondrial OS=Bos taurus OX=9913 GN=HMGCL PE=2 SV=2 |
| Q8TB92 | 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic OS=Homo sapiens OX=9606 GN=HMGCLL1 PE=1 SV=3 |
| Family type | Membership / link |
|---|---|
| Orthogroup (gene family) | OG0003375 (this species only) · gene tree & orthology |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF00682 all species → | HMGL-like | HMGL-like | Domain | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR013785 all species → | Homologous_superfamily | Aldolase-type TIM barrel | Interproscan |
| IPR000891 all species → | Domain | Pyruvate carboxyltransferase | Interproscan |
| IPR043594 all species → | Family | HMG-CoA lyase | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR42738 all species → | HYDROXYMETHYLGLUTARYL-COA LYASE | Interproscan |
| GO term | Category | Description | Source |
|---|---|---|---|
| GO:0003824 all species → | Molecular Function | catalytic activity | Interproscan |
| GO:0004419 all species → | Molecular Function | hydroxymethylglutaryl-CoA lyase activity | Interproscan |
| GO:0006552 all species → | Biological Process | L-leucine catabolic process | Interproscan |
| GO:0016833 all species → | Molecular Function | oxo-acid-lyase activity | Interproscan |
| GO:0046951 all species → | Biological Process | ketone body biosynthetic process | Interproscan |
| KO | Enzyme | Enzyme ID | Pathway | Map ID | Source |
|---|---|---|---|---|---|
| K01640 | HMGCL, hmgL; hydroxymethylglutaryl-CoA lyase | EC:4.1.3.4 | Peroxisome | ko04146 | deepkoala |
Genes whose expression across the transcriptome samples of Eunicella cavolini tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.
No co-expression network has been built for this species, so this gene has no partners to show. Networks are available for the species listed on the Network Analysis page.
Whether this gene can be visualised in the single-cell atlases of Eunicella cavolini, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.
No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.
Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.
No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.
Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.
| Analysis | What it does | Status | |
|---|---|---|---|
| Primer design | Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed. | template found | open → |
| BLAST | Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start. | template found | open → |
| Expression heatmap | Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it. | no expression matrix | – |
| Gene family / orthogroup | Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue. | open → | |
| Gene set analysis | Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it. | open → |
