Genomic Location: chr4:40436121...40437998
NR annotation: CAB3986986.1, endonuclease III 1 [Paramuricea clavata]
Species Eunicella cavolini · all data for this species · gene families
| CDS |
| ENSLDHT00000037812 |
| Protein |
| ENSLDHP00000034854.1 |
| UniProt accession | Description |
|---|---|
| A7M7B9 | Endonuclease III-like protein 1 OS=Gallus gallus OX=9031 GN=NTHL1 PE=2 SV=1 |
| O35980 | Endonuclease III-like protein 1 OS=Mus musculus OX=10090 GN=Nthl1 PE=2 SV=2 |
| P78549 | Endonuclease III-like protein 1 OS=Homo sapiens OX=9606 GN=NTHL1 PE=1 SV=3 |
| Family type | Membership / link |
|---|---|
| Orthogroup (gene family) | OG0007221 (this species only) · gene tree & orthology |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF00730 all species → | HhH-GPD | HhH-GPD superfamily base excision DNA repair protein | Domain | Interproscan |
| PF00633 all species → | HHH | Helix-hairpin-helix motif | Motif | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR004035 all species → | Binding_site | Endonuclease III, iron-sulphur binding site | Interproscan |
| IPR023170 all species → | Homologous_superfamily | Helix-hairpin-helix, base-excision DNA repair, C-terminal | Interproscan |
| IPR011257 all species → | Homologous_superfamily | DNA glycosylase | Interproscan |
| IPR003651 all species → | Conserved_site | Endonuclease III-like, iron-sulphur cluster loop motif | Interproscan |
| IPR003265 all species → | Domain | HhH-GPD domain | Interproscan |
| IPR030841 all species → | Family | Endonuclease III-like protein 1 | Interproscan |
| IPR000445 all species → | Conserved_site | Helix-hairpin-helix motif | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR43286 all species → | ENDONUCLEASE III-LIKE PROTEIN 1 | Interproscan |
| GO term | Category | Description | Source |
|---|---|---|---|
| GO:0003824 all species → | Molecular Function | catalytic activity | Interproscan |
| GO:0006281 all species → | Biological Process | DNA repair | Interproscan |
| GO:0000703 all species → | Molecular Function | oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity | Interproscan |
| GO:0003906 all species → | Molecular Function | DNA-(apurinic or apyrimidinic site) endonuclease activity | Interproscan |
| GO:0005634 all species → | Cellular Component | nucleus | Interproscan |
| GO:0006285 all species → | Biological Process | base-excision repair, AP site formation | Interproscan |
| GO:0006296 all species → | Biological Process | obsolete nucleotide-excision repair, DNA incision, 5'-to lesion | Interproscan |
| GO:0051539 all species → | Molecular Function | 4 iron, 4 sulfur cluster binding | Interproscan |
| GO:0006284 all species → | Biological Process | base-excision repair | Interproscan |
| GO:0019104 all species → | Molecular Function | DNA N-glycosylase activity | Interproscan |
| GO:0003677 all species → | Molecular Function | DNA binding | Interproscan |
| KO | Enzyme | Enzyme ID | Pathway | Map ID | Source |
|---|---|---|---|---|---|
| K10773 | NTHL1, nth; endonuclease III | EC:3.2.2.- EC:4.2.99.18 | DNA repair and recombination proteins | ko03400 | deepkoala |
Genes whose expression across the transcriptome samples of Eunicella cavolini tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.
No co-expression network has been built for this species, so this gene has no partners to show. Networks are available for the species listed on the Network Analysis page.
Whether this gene can be visualised in the single-cell atlases of Eunicella cavolini, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.
No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.
Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.
No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.
Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.
| Analysis | What it does | Status | |
|---|---|---|---|
| Primer design | Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed. | template found | open → |
| BLAST | Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start. | template found | open → |
| Expression heatmap | Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it. | no expression matrix | – |
| Gene family / orthogroup | Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue. | open → | |
| Gene set analysis | Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it. | open → |
