Genomic Location: chr4:42821682...42884864
NR annotation: XP_028405742.1, E3 ubiquitin-protein ligase HERC2-like [Dendronephthya gigantea]
Species Eunicella cavolini · all data for this species · gene families
| CDS |
| ENSLDHT00000038018 |
| Protein |
| ENSLDHP00000035029.1 |
| UniProt accession | Description |
|---|---|
| O95714 | E3 ubiquitin-protein ligase HERC2 OS=Homo sapiens OX=9606 GN=HERC2 PE=1 SV=2 |
| Q4U2R1 | E3 ubiquitin-protein ligase HERC2 OS=Mus musculus OX=10090 GN=Herc2 PE=1 SV=3 |
| Q9VR91 | Probable E3 ubiquitin-protein ligase HERC2 OS=Drosophila melanogaster OX=7227 GN=HERC2 PE=1 SV=3 |
| Family type | Membership / link |
|---|---|
| Orthogroup (gene family) | OG0002592 (this species only) · gene tree & orthology |
| Ubiquitin family | E3|E3 activity|HECT · all ubiquitin genes in this species |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF00632 all species → | HECT | HECT-domain (ubiquitin-transferase) | Domain | Interproscan |
| PF00173 all species → | Cyt-b5 | Cytochrome b5-like Heme/Steroid binding domain | Domain | Interproscan |
| PF11515 all species → | Cul7 | Mouse development and cellular proliferation protein Cullin-7 | Family | Interproscan |
| PF00569 all species → | ZZ | Zinc finger, ZZ type | Domain | Interproscan |
| PF00415 all species → | RCC1 | Regulator of chromosome condensation (RCC1) repeat | Repeat | Interproscan |
| PF06701 all species → | MIB_HERC2 | Mib_herc2 | Domain | Interproscan |
| PF03256 all species → | ANAPC10 | Anaphase-promoting complex, subunit 10 (APC10) | Family | Interproscan |
| PF18346 all species → | SH3_15 | Mind bomb SH3 repeat domain | Domain | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR000408 all species → | Repeat | Regulator of chromosome condensation, RCC1 | Interproscan |
| IPR037252 all species → | Homologous_superfamily | Mib/herc2 domain superfamily | Interproscan |
| IPR043145 all species → | Homologous_superfamily | Zinc finger, ZZ-type superfamily | Interproscan |
| IPR000569 all species → | Domain | HECT domain | Interproscan |
| IPR036400 all species → | Homologous_superfamily | Cytochrome b5-like heme/steroid binding domain superfamily | Interproscan |
| IPR004939 all species → | Domain | APC10/DOC domain | Interproscan |
| IPR000433 all species → | Domain | Zinc finger, ZZ-type | Interproscan |
| IPR001199 all species → | Domain | Cytochrome b5-like heme/steroid binding domain | Interproscan |
| IPR021097 all species → | Domain | CPH domain | Interproscan |
| IPR009091 all species → | Homologous_superfamily | Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II | Interproscan |
| IPR010606 all species → | Domain | Mib-herc2 | Interproscan |
| IPR035983 all species → | Homologous_superfamily | HECT, E3 ligase catalytic domain | Interproscan |
| IPR008979 all species → | Homologous_superfamily | Galactose-binding-like domain superfamily | Interproscan |
| IPR040847 all species → | Domain | Mind bomb, SH3 repeat domain | Interproscan |
| IPR051210 all species → | Family | Ubiquitin ligases and GEF domain-containing protein | Interproscan |
| IPR014722 all species → | Homologous_superfamily | Large ribosomal subunit protein uL2, domain 2 | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR22870 all species → | REGULATOR OF CHROMOSOME CONDENSATION | Interproscan |
| GO term | Category | Description | Source |
|---|---|---|---|
| GO:0004842 all species → | Molecular Function | ubiquitin-protein transferase activity | Interproscan |
| GO:0046872 all species → | Molecular Function | metal ion binding | Interproscan |
| GO:0008270 all species → | Molecular Function | zinc ion binding | Interproscan |
| GO:0016567 all species → | Biological Process | protein ubiquitination | Interproscan |
| KO | Enzyme | Enzyme ID | Pathway | Map ID | Source |
|---|---|---|---|---|---|
| K10595 | HERC2; E3 ubiquitin-protein ligase HERC2 | EC:2.3.2.26 | DNA repair and recombination proteins | ko03400 | deepkoala |
Genes whose expression across the transcriptome samples of Eunicella cavolini tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.
No co-expression network has been built for this species, so this gene has no partners to show. Networks are available for the species listed on the Network Analysis page.
Whether this gene can be visualised in the single-cell atlases of Eunicella cavolini, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.
No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.
Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.
No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.
Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.
| Analysis | What it does | Status | |
|---|---|---|---|
| Primer design | Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed. | template found | open → |
| BLAST | Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start. | template found | open → |
| Expression heatmap | Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it. | no expression matrix | – |
| Gene family / orthogroup | Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue. | open → | |
| Gene set analysis | Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it. | open → |