Gene detail

Detailed information of ENSLDHP00000043475.1 in Eunicella cavolini

Genomic Location: chr7:2135512...2144930
NR annotation: CAB4003215.1, ephrin type-A receptor 5 isoform X2, partial [Paramuricea clavata]
Species Eunicella cavolini · all data for this species · gene families

Gene Structure

More details in JBrowse

Sequence

CDS

ENSLDHT00000047639

ATGAATTTTATATGGGAAATGTCATTCATTTTTTCACTCTATATAATATTAAGCGCTTTTCATATACGTCATTTAGCTGGTAAAAAAGCGATTATAAAGACAAACACATGTTCAGAATATTTTGAACGTAGTATAGAAGATCCTAACAACAAAACTACTTCGTGGATACCCAATAAAGAATCTGCAAGGCTCGATTGCTCCATTTGCAATGCACAAGACACAACAAACTCTTGGTTGGTCACAAATCCTATAAAGCTAGCTAAAGAACTCAAGTCAATACATGTAAATGTCAAAATGTTCAGATCAGAATGTGATGGGTGCCGAAATCAGGATATAAGAGTTTATGTTTTACACAAAACCTTGCCACGTCAGAACACCAAAATACAACAAGCTGTCGACATTTTAAAGAATTTGAAGTTGGTAGCAACTTTTAGAAATGAAAAGGACCTAACAGAGCAAAATCATCATTTTCACTTTGAACCCAAAGGAATGGAATTCTCCATGGTGTTTCTCTCTGCTGGAAGCTGTACCGTGATAAAACAGATCACTGTATCTTATTTCTTTTGTGGCAAAAACACTAGCAGTGGGGTTAATCTCCCCAGAACAGATGCTCCAGCTAATGGATCTCAAAGGGTGAATGTAAGTTGTCCTAAGAACACATTAAATCCAGGAAATGATGAAGCATATGGACTGTGTTCAAGTGAAGGAAAATGGGATATTATATCACCATGCATGTGTAAAAAAGGATACACCTTAAATACTATTGAAGAAGGCTGCATGGaatGTCCAGAAAACAGTTATAAAGATGCAGTTGGGAATGAAAAATGCACTGACTGTCCAAGTAATTCCAAAGCTAATCCCAGCGGTCAAGTTCAGTGTTCCTGTCAAGATGGTTTCTATCGCTTTCAAGGGGAAAATCATACACATTCATGTTACGGAGTTCCTTCGCCTGTCACAGACATTAAGTTTATTGACAGAACTGAAACCTCGATTACGTTGCTATGGCAAGTGCCAGAACCGCCTGACCAGGATGTGCTGTATGACATAAAATGCAATAAGTGTACGTCAGGTAGTAATAGTGGGTTGTGCGAAGAGTCGTGTGGAAGCTCAGTGACGTTTAAACCATCCCAAAATAATCTTACGCATACAAATGTAACCATACGAGGTCTCAAAGGAGATACGGAATACGAATTCGTGATTTATTCCAAAAATAGCAACAGTCTGCGCATCAATATGACCAACTGGTCTTCGCAAAGGAAAAAAATTAAGACTGAAGGAACATCCAAACAGGATGGTCTTTCTAAACTGGTTGTAATTGCTGTTCCAGTGCTTGTTGTTGTCCTGATGgtgattattattattcttgGCGTTTGTTTGTTTAAACGTATAGTCTGTCAACATCAGATGAATATTACAATGCTGGTATATTATGATTTAGATTTCCCTCTAATGCCCGGTGAGAAAAACTATATTGATCCAACGACATACGACAATCCCGAAAGAGCGGTGTCCGAGTTTACAAAAGAACTGGACAGAGATGTGATTAAATTTGAATCCCTTATTGGTGGAGGGGAGTTTGGTGATGTTTACAAAGGCGAAATTAAGCTTCCTGGGCAACCAGCAACAAAGGTGGCAATTAAAACACTAAAGGCGGGAGCATCGTACAAAAACCGAACAGACTTTCTCATTGAAGCGTCTGTGATGGGGCAGTTTAAGAACTTGAACGTGATCACTTTGGAAGGTGTTGTGACTCGAAGCACACCGTTACTCATTGTGATAGAATTTATGGAGAATGGATCTTTagataaatatttgaagGAAAATGATGGGTTGTTAAAACCATTACAACTGTTAGGAATGGCTCGGGGAGTTGCCAGTGGCATGGAATATTTGGCCGGGATGCATTTTGTTCATAGGGATTTGGCTGCCAGAAATGTTTTAGTTAACGCCAATCTTGCTTGTAAAGTTGCTGACTTTGGCCTATCCAGGGATCTTGGCAATACTCAAGACTCCGAGTATGAAACGCAGGGAGGCAAGATTCCTGTGCGATGGACAGCTCCCGAAGCCATTACCTATCGTAAATTTTCAACAGGCAGTGATATCTGGAGTTTTGGTATTCTACTTTGGGAAATAATGTCCTTTGCTGAAAGACCTTATTGGAATTGGGGCAACGACGAAGTTATGACAAGGGTCGATCAAGGATACAGGCTGCCTCCACCAATGAATTGTCCTAAAACAGTACATCAGTTAATGAAAGAATGCTGGTTGACAGACAGAACGAAACGACCACCATTTAAAGAAATTGTGAGAATCATTGATGAATGGATTAAATATCCCGAAAAACTTAATGAAGACTATATCAAAGTGAGAAGGACTGAGCCATTGGACTACTCAACATTCACTTCAGTAAAGGATTGGTTAGAGGCCATAAAGATGGGAATGTATGCCAGTAATTTTTCCAAGGCGGGCTACGAAGAATTGACTGAAGTCGCTCAACTCACTGAAGATGAACTCTTAAAGAAAGTCGGAGTTAGGCTGGTTGGACATCGGCATAAAATTTATCAGAGGATCAAAGAAATGAGCGAGGACATGAGGTTGAAGCGTGAGCAATCGGTGAGAATTTGA

Protein

UniProt (Swiss-Prot top hit)

UniProt accession	Description
Q91735	Ephrin type-B receptor 3 OS=Xenopus laevis OX=8355 GN=ephb3 PE=2 SV=1
Q60629	Ephrin type-A receptor 5 OS=Mus musculus OX=10090 GN=Epha5 PE=1 SV=2
Q07494	Ephrin type-B receptor 1 (Fragment) OS=Gallus gallus OX=9031 GN=EPHB1 PE=2 SV=2

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0000240 (this species only) · gene tree & orthology

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF07714 all species →	PK_Tyr_Ser-Thr	Protein tyrosine and serine/threonine kinase	Domain	Interproscan
PF00041 all species →	fn3	Fibronectin type III domain	Domain	Interproscan
PF14575 all species →	EphA2_TM	Ephrin type-A receptor 2 transmembrane domain	Domain	Interproscan
PF00536 all species →	SAM_1	SAM domain (Sterile alpha motif)	Domain	Interproscan
PF07699 all species →	Ephrin_rec_like	Tyrosine-protein kinase ephrin type A/B receptor-like	Domain	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR036116 all species →	Homologous_superfamily	Fibronectin type III superfamily	Interproscan
IPR001660 all species →	Domain	Sterile alpha motif domain	Interproscan
IPR011009 all species →	Homologous_superfamily	Protein kinase-like domain superfamily	Interproscan
IPR003961 all species →	Domain	Fibronectin type III	Interproscan
IPR050449 all species →	Family	Ephrin receptor tyrosine kinases	Interproscan
IPR020635 all species →	Domain	Tyrosine-protein kinase, catalytic domain	Interproscan
IPR001090 all species →	Domain	Ephrin receptor ligand binding domain	Interproscan
IPR001245 all species →	Domain	Serine-threonine/tyrosine-protein kinase, catalytic domain	Interproscan
IPR013761 all species →	Homologous_superfamily	Sterile alpha motif/pointed domain superfamily	Interproscan
IPR013783 all species →	Homologous_superfamily	Immunoglobulin-like fold	Interproscan
IPR017441 all species →	Binding_site	Protein kinase, ATP binding site	Interproscan
IPR027936 all species →	Domain	Ephrin receptor, transmembrane domain	Interproscan
IPR000719 all species →	Domain	Protein kinase domain	Interproscan
IPR008266 all species →	Active_site	Tyrosine-protein kinase, active site	Interproscan
IPR011641 all species →	Domain	Tyrosine-protein kinase ephrin type A/B receptor-like	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR46877 all species →	EPH RECEPTOR A5	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0005515 all species →	Molecular Function	protein binding	Interproscan
GO:0005005 all species →	Molecular Function	transmembrane-ephrin receptor activity	Interproscan
GO:0005887 all species →	Cellular Component	plasma membrane	Interproscan
GO:0006468 all species →	Biological Process	protein phosphorylation	Interproscan
GO:0007411 all species →	Biological Process	axon guidance	Interproscan
GO:0030425 all species →	Cellular Component	dendrite	Interproscan
GO:0048013 all species →	Biological Process	ephrin receptor signaling pathway	Interproscan
GO:0004713 all species →	Molecular Function	protein tyrosine kinase activity	Interproscan
GO:0004672 all species →	Molecular Function	protein kinase activity	Interproscan
GO:0005524 all species →	Molecular Function	ATP binding	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

KO	Enzyme	Enzyme ID	Pathway	Map ID	Source
K05108	EPHA7, EHK3, HEK11; EphA7	EC:2.7.10.1	Protein kinases	ko01001	deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Co-expression network

Genes whose expression across the transcriptome samples of Eunicella cavolini tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

No co-expression network has been built for this species, so this gene has no partners to show. Networks are available for the species listed on the Network Analysis page.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Eunicella cavolini, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

Analysis	What it does	Status
Primer design	Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.	template found	open →
BLAST	Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.	template found	open →
Expression heatmap	Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.	no expression matrix	–
Gene family / orthogroup	Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.		open →
Gene set analysis	Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.		open →