Gene detail

Detailed information of ENSLDHP00000048317.1 in Eunicella cavolini

Genomic Location: chr9:17591380...17600843
NR annotation: XP_028409178.1, dual oxidase 2-like [Dendronephthya gigantea]
Species Eunicella cavolini · all data for this species · gene families

Gene Structure

More details in JBrowse

Sequence

CDS

ENSLDHT00000053010

ATGACGACAGATATTGACCCAGATGACATTCAAGAAGATCCTTTCTTCACGAACGGCGCTAAGTGTCAATTAGGGAGACTTAAAAAGGACCAGGTTGCAGATTGCACAGAACCTAAGACATTTGATTACTTTGATGGCAGTGAAGTGTCTTATGCTTTGACTTGGCTATTCGCTGGATTGTTCTGTGTTGGTGTGGTATTAGTGATGTTATTCCTGGCTAAACGTCGCCAGAAAATGTTGGCTGAGAAACGAAAAAGTAATCGCCGAAAAACTCAACGAAATAGCAAACCTGTAGACAACGAATTTATCGCCGCTGAATGGAGACGTAATCTTCCGGACAGAACAGTGAAAGTGAAGCTAGGTCAAGGAAAGATAGTACGAGTGTCTTCAGAGCGAGGCCAACTACTCAGGACGATCGACCTCAGAGGGATGGAGTGGATTATCGTCTTCTTACAGAGTGACAAAGAACAAACATTGCTATCTGTTAGAATGGACAGAGAATATGATATGATTTTGAAGTTTGATTCGGAAGTACAAAGAGGACAGTTCGTGCAAAGTTTTGAGGGATTCTTGAACAATCACGACATCAAATGCACCAGAAATGAAATGAAGACACAAATGTTGATGTCCTCAGCGCATACTAAAGAAGATCGACAAAAAAGACTGGAAAAATTCTTCCGAGTTGCTTTTGCTCATGCTTTTGACATTGAGTATCAAGATCAAGATTTCAACGAGAGGATGGGCGAGGCAAAGGAAGTGCTCTCATGTGAACTTTCAAGAACTGAATTCGCCGAAGCACTTTCTCTGAAACCCAAATCGCTTTTCGTGGAACAGATGTTCGATCTGGTTGATAAAGATCGTAATGGATATCTGTCATTCCGAGAATTCCTTGACGTCATTGTTATTTTTGCTAAAGGTACCCCAGATGAGAAACTGCGATTGTTCTTCGATATGTATGATATTTCTGGTGACCAAAAACTGGGTCGAGACGAATTTAAACAAATGATCAAGTCGTTTATGGAGCTGGTGAATGCTGATGTTGAAGCAGACCAGCTGGACACTCTTACTGACTCGATGTTCTCACAAGCTGGCTTTACGAACAAGGATGAACTGACATTTGATGACTTCAGAGCTGTCATGGCTGAATATAAGGAACATTTGGAAGATGCCGAACTTAATTTGTCAGGAACGGGTGTTGATGTACCTGGCAAGTCGCCTGCCAAGTCAGGAACGGGCGGTAAAGACAAAAAGAGGGAAAATGCTCCGACTCGTGCCAGAAAAACTGTGATCAAACATTTGAACACCACTCCTGATCGCGCTCCAAAACGGAGTTCAACCAAAGTTAGAGTCGCTACAAAGAGGACCAAGGACTACGATAATGTGATTGTGAAGAACTGGACAATCTTCGCGAGATATGTGTCTAATCATATCTCGGATATCTTCATTGCTGTATTGTATACTCTGGTACTCATTGCTATCTTTGCCGAGAGAGCTTACTATTACTCCGTAGAACGTGAACATGGAGGATTACGTCGTATCGCAGGTTATGGTGTGACCGTGACGAGAGGTGCTGCAAGTGCCATGATGTTCACCTTCTCTTCTCTCCTCGTCACTATGTGTCGAAATCTCATCACATTCCTCAGGGAGACTTTTGTTGGACATTATGTACCCTTTGATTCAAATGTTTTGTTCCATAAATATATCGCATTCTTGGCTTTATTCTTTACTGtGATGCACTGCATTGGCCATTCAATCAACTTCTACCACGTCGCCACCCAACCACCAAATGATTTGACATGTCTGTTCAGAAACTATTTCCACAGATCTCATGAACTGCCAAAGTTTCATTACTGGTGCTGGGAGACAATCACAGGTCTCACTGGAGTATTCCTGCTGCTCGTAATTGTCATCATGTACGTATTCGCGACGCAGTACTCAAGACGTCATGTCTTCACATCATTCTGGCTTACTCATCAACTCTACATCGTTCTATATCTTCTCATGGTTTTACACGGCAGCGGTAACCTTGTACAGCGGCCATTCTTCCACTATTTCTTCTTGGGTCCAGGGATTTTGTTCGCACTCGATAAGTTGGTGAGCATGTCTCGTAAGAAAGCCAACATTGCTGTTATGAAAGCAGAATTATTGCCGTCAGATATCATTCATTTGGAGTTTAAACGTCCACCTAGCTTTGAATACAAGGCAGGTCAATGGTGCCGTATTGCCTGCCACAGTCTTGGAGGGGGAGAGTATCATCCATTCACCCTGACTTCTGCTCCTCATGAAGATAACCTGAGTCTGCATATCAGGTCTGTAGGACCTTGGACCATCAACTTACGACAGACATATGATCCTGCCAATCTTCAGTCGAAAGCTTACCCTCAGTTATATTTAGATGGACCATTTGGTGAAGGCCACCAAGATTGGTATCGTTTTGAAGTATCAGTGTTGGTGGGAGGAGGGATTGGAGTCACACCTTTTGCTTCAATATTGAAAGATATTGCTCATAAAGGATCAATCAAGTCCACATTCACCTGCAAGAAGGTTTATTTCATCTGGGTGACTCGAACACAGAAACATTTTGAATGGTTGACTGATATTATCCGTGAAGTTGAGGAGAAAGATCAGAATGATCTCGTCAGTGTTCATATCTTTGTCACTCAGTTCTATCACAAGTTTGATCTGAGAACTACAATGTTGTACATCTGTGAACGTCATTTCCAGAAGATCTCAGGAAAGTCTCTATTTACTGGACTGCGATCTATCACTCATTTCGGACGACCTGACTTCCTGTCTTTCCTGGAATCTCTTTCTACTACCATCCACCCAGAGGCGTCTAAGATAGGTGTGTTTAGCTGTGGACCCCCCGCAATGACAAGAGGTGTGGAAAGCGCATGTGCAGAACTGAACAAGACCGAGGGAGCGGCATTCATTCATCATTTCGAGAATTTCTAA

Protein

UniProt (Swiss-Prot top hit)

UniProt accession	Description
Q9ES45	Dual oxidase 2 OS=Rattus norvegicus OX=10116 GN=Duox2 PE=2 SV=1
Q9MZF4	Dual oxidase 1 OS=Canis lupus familiaris OX=9615 GN=DUOX1 PE=1 SV=1
Q9NRD8	Dual oxidase 2 OS=Homo sapiens OX=9606 GN=DUOX2 PE=1 SV=2

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0011265 (this species only) · gene tree & orthology

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF08030 all species →	NAD_binding_6	Ferric reductase NAD binding domain	Domain	Interproscan
PF08022 all species →	FAD_binding_8	FAD-binding domain	Domain	Interproscan
PF01794 all species →	Ferric_reduct	Ferric reductase like transmembrane component	Family	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR039261 all species →	Homologous_superfamily	Ferredoxin-NADP reductase (FNR), nucleotide-binding domain	Interproscan
IPR050369 all species →	Family	Respiratory burst oxidase/Ferric reductase	Interproscan
IPR013121 all species →	Domain	Ferric reductase, NAD binding domain	Interproscan
IPR002048 all species →	Domain	EF-hand domain	Interproscan
IPR018247 all species →	Binding_site	EF-Hand 1, calcium-binding site	Interproscan
IPR017927 all species →	Domain	FAD-binding domain, ferredoxin reductase-type	Interproscan
IPR017938 all species →	Homologous_superfamily	Riboflavin synthase-like beta-barrel	Interproscan
IPR011992 all species →	Homologous_superfamily	EF-hand domain pair	Interproscan
IPR013112 all species →	Domain	FAD-binding 8	Interproscan
IPR013130 all species →	Domain	Ferric reductase transmembrane component-like domain	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR11972 all species →	NADPH OXIDASE	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0005886 all species →	Cellular Component	plasma membrane	Interproscan
GO:0006952 all species →	Biological Process	defense response	Interproscan
GO:0016175 all species →	Molecular Function	superoxide-generating NAD(P)H oxidase activity	Interproscan
GO:0042554 all species →	Biological Process	superoxide anion generation	Interproscan
GO:0043020 all species →	Cellular Component	NADPH oxidase complex	Interproscan
GO:0016491 all species →	Molecular Function	oxidoreductase activity	Interproscan
GO:0005509 all species →	Molecular Function	calcium ion binding	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

KO	Enzyme	Enzyme ID	Pathway	Map ID	Source
K13411	DUOX, THOX; dual oxidase	EC:1.6.3.1 EC:1.11.1.-	Membrane trafficking	ko04131	deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Co-expression network

Genes whose expression across the transcriptome samples of Eunicella cavolini tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

No co-expression network has been built for this species, so this gene has no partners to show. Networks are available for the species listed on the Network Analysis page.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Eunicella cavolini, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

Analysis	What it does	Status
Primer design	Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.	template found	open →
BLAST	Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.	template found	open →
Expression heatmap	Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.	no expression matrix	–
Gene family / orthogroup	Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.		open →
Gene set analysis	Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.		open →