Gene detail

Detailed information of ENSLDHP00000049055.1 in Eunicella cavolini

Genomic Location: chr9:5860549...5886758
NR annotation: CAB3982629.1, brefeldin A-inhibited guanine nucleotide-exchange 1 isoform X1 [Paramuricea clavata]
Species Eunicella cavolini · all data for this species · gene families

Gene Structure

More details in JBrowse

Sequence

CDS

ENSLDHT00000053881

ATGTACAAAACCACAAAGACAAAAAATGTATTCCTTTCGCGAGCTTTGGAGAAAATCCTTCATgacaaagaaacaaagaaatcaCATCATTCACAGTTGAAGAAAGCTTGCGAAACTGCTTTAGGTAatggtaaatatatattattaatgaaGGACAGTTCTTCAGCAACGCTACCTCCACCCCCTGGTCAACAAACGTTTATCACAGCAGATCAATATTTCTTGCCATTTGAACTGGCTTGTCAGTCCAAGTGTACAAGAATTGTTGTTACTGCCCTTGACTGTATACAGAAACTGATTGCATATGGTCATATAGTTGGTGACACACCTGATTCAATTGAACCTGAGAAGCGTTTGATAGATAGGATAATTGATACAATATGTGGTTGCTTTACTGGCATTCATACTGATGAAGGTGTTCAGCTTCAAATTATTAAGGCACTGCTTACTGCAGTCACATCAAGTACATGTGAAGTTCATGAGGGAACACTACTTCAAGCTGTTCGTACAGTGTATAATATATACCTCGCCAGTAGAAATCTCATCAATCAAACTACAGCCAAGGCAACTCTCACACAGATGATCAGTTTGGTCTTTCAAAGAATGGAAAGCCAAGCAGTGGCTGCTGCAAAACTCCAAGAGGAATTAGCTGCAGAAATGAAAAGTCTTGAAAGTGAGGGGAAAGAAGAGCCATCACAAGATGGGTCTGAAGAAAAACATGATGAAAGTTTGAAGAATGAAGCAGAACATGTAAAAGAAGATCAAACTTTGCCCAATGGTGAGGTAGTTCAAGATGAAGATGAAGGTGTTGATTTAAGAGGAGATGTAGAAAATGAAGAAACTAAGCATGAAACAGACACAGCCAATTCAAACAACTTACAACCAGATACTCTTCAAGCAGAACAACACGAGACTCGAGATGATACAACAAAAGACTCTACTATTTCAGAGCATGATCAAAGCGGCAAGACAGCGGACTGTGATTCATCTGACATTGCAAACGAAACAAGTTCTGGTGTTAATGAAGATGCAACTGATTCGGCTGGCTCAAATGATACTCCATCAACACAACAGAATGAAGAAACCTCTGAGGATATAAGTGAAATctctgaaaatataaaagaatCCTCTGAAAATAAAGACGAAAGTTCTGAAAACATACCAATTAATAAAACTGAAAATAATTCATCTGATAGTCAAAGTGAACCGAAGCCAGACAATCAGATATCTGAAAATAACCAAAACGTGAATAACAAAGAACCTGTAGAAATACCACCGATTCAAATTCCTGACGACCGGCAAACCAAGGCGGATGTAACCATACCAGACGATATTTCAGAAACGCATGAAGAAGGCTTAGATACAGCGAGAAGTTCGGTCTCTGAAGCTCATTCTGATATGCCCAGTGAGGGAACCGGCGAGGGAAAACCACAGCAGAGATTTTCTCATATCACTCAAAAAGATGCTTTCTTAGTATTCCGTTCATTGTGTAAACTATCTATGAAGCCGTTGGCTGACGGACCTCTGGATCCCAAGTCTCACGAACTAAGATCAAAAGTCTTGTCTTTGGAACTGTTGTTAGCTTGTCTTCAAAGTGCTGGCCCAGTGTTCCGTACTCACCCCATGTTTATCAACGCTATTAAACAGTATTTGTGCGTGGCGTTGTCGAAGAATGGAGTCTCTTCTGTTCCAGCTGTGTTTGAACTTTCTTTGGCAATCTTCTTGACTTTACTGTCATACTTTAAAACTCATCTTAAAATGCAAATTGAGGTTTTCTTTAAAGATATATTTCTTAATATCTTGGAGACCTCGACCAGTTCTTTTCAGCACAAATGGATGGTAATGCAGACGTTAACAAGGATTTGTTCAGACGCACAGACTGTTGTTGACATTTATCTGAACTACGATTGCGAGCTGGCTTtatcaaatatttttgaaaGACTGATCAACGATCTCTCTAAAGTAGCGCAAGGACGTCAAGCAATTGAACTCGGTGCCACACCAGTCCAAGAACGAAGCATTCGAATTAAAGGTCTTGAATGTTTGGTCTCAATCTTAAAGTGTATGGTTGAATGGAGTCGTGATCTTTACTTTAGACCTGATTCACAAGTCGATGATAATTTAGACTTCGAGGATGGTACACCTACCATGCCACGCAAAGGAAGTACCATTGACGAGGAAGGTGGTGAAGGTGGAGATGGTGACTTACAGTCCATAAAAGCAGGGGGAAGTCAAAACTCGCTCAACAATGGCCAGCCTCTTGATAACGCTGAACAATTTGAGAGTTTGAAACAGAAGAAAGAAAAGACACTGAAAGGCATACAACTATTCAATAAAAGTCCTCCCAAGGGTTTAAAATTTCTTCAAGCTGAAGGTCTGTTGGGAGATTCAGTGATTGAAGTCGCACAGTTTTTACACACGGATGATAAATTGGATAAGACAATGATTGGAGAGCTGCTCGGTGATCCTGGCCAATACGAACGTGAAGTGATGTACGCATACATAGATCAACTTGATTTCTCTGGAATAAATCTTGTGCAAGCTTTACGTCAGTTTCTACACAACTTTCGCTTGCCTGGTGAAGCGCAAAAGATTGACAGGTTGATGGAAAAGTTTGCAAGTAGATTTTGCGAGACGAATCCAAATGACGATGTATTTGCGAGTGCTGATGCTGCCTACGTGTTGGCGTATTCTATTATCATGTTGACAACTGATTTGCACAGCTCTCAGGTCAAACGTAAGATCACGAAAGAGCAATATATTCAAATGAATCGCGGGATTAATGATAATAAAGACTTACCACCCCAATATCTAGAAGCAATTTATGATGATATAGCACAGAATGAAATTAAAATGAAACATACACCTAAAATCAACAGCAGATATGATGCCACGTACTTACAAAGCGAAAAACATCGTCGTATGTTATACTCTATGGAAATGGAACACATGGCGGAGAATGCTAAAACACAAATGGAAGATGTCAGTCACATTCAAACAGACTTTGTTACCGCTACACAAATTGGTCACGTGAAAACCATGTTTAAGGTTGCTTGGAGCCCATTTCTAGCTGCATTTAGTGTAAATCTTCAGGATAACGACGATCCGTCCGTAGCATCTTTGTGTCTGGATGGCATTCGCTGTGCAATCAGAATATCGTGTATTTTTAGTATGCCTTTGGAAAGAGATGCATTCGTGCAAGCTTTGTCAAGATTCACACTCCTCTCTGCCACCAGTGGAACGCATATTCACGAAATGAAAAACAAGAATATTGAGACGATAAAGACATTAATTACCATCGCGCAAACGGATGGTAATTATGTCGGAAAATCTTGGTTAGAGATTTTGAAATGTATTTCTCATCTGGAACTTGCTCAGTTGATCGGTACTGGAGTGAAAACGCGATATCTTCATACGGGAGCCAGCGGTATTACTAATTCTGGTACAGCCCCTACAGCCAGCCACCATAGGACAGCCCATGACGTCACCGCAGGTAGGTTGACGGGAAAAGACTCTAAGAGAATGGCAAGTGTTCAAGAAGCAATTGGAGAAACAGCAACGCAGAGTGTCGTTGTGGCTGTTGACAGAGTTTTCACTGGCTCAGTAAAACTAGATGGGGATGCTATAGtcgACTTCGTTGAAGCATTACGACAGGTTTCGGAAGTTGAACTTTCGAACGCGACTATGATCCGAATGTTCAGTCTCCAGAAAATCGTGGAGATTGCGTATTATAATATGGGTCGTATCAGATTGCAATGGTCGAGGATATGGGCTGTGTTAGGTGATCATTTTAATAAGTGTGGATGTAATCCCAATGAAGAAGTGGCTTTCTTTTGTGTTGATTCTCTGCGACAGTTATCTATGAAATTCTTAGAAAAAGGAGAGTTACCAAACTTCCGCTTTCAGAAAGACTTTCTCAGACCTTTTGAATACATCATGAACAAAAATCGCTCAGCGACAATACGTGACATGGTCGTTCGCTGTGTGGCACAGATGGTTCACTCTCAAGCTGTGAATATCAAGTCTGGTTGGAAAAATGTCTTTTCTGTTTTTCATTTGGCTGCATCGGATCATGACGAAGGAATTGTTGAATTGGCGTTCCAAACTACAGCGACGATTTTTGAGAAGTACTTTTCTGCGACCATCGACTCGTTCCAAGATGCAGTGAAATGTCTTTCAGAGTTCGCGTGTAATGCTAGTTTCCCTGACACGAGTATGGAAGCAATTCGTCTCATCCGAAATTGTGCCAAGTTTGTCTTTGAAAACCCCTTGATGTTTAAAGATCACGGTGTTGAGGATGCTGGTATTTCAGAGCAAGATCGTATTTGGGTAAAAGGATGGTTTCCAGTTCTGTTTGAATTATCGTGTATTATCAATCGATGTAAGCTGGATGTCAGGACCAGAGGTTTGACGGTGATGTTTGAAATAATGAAGACTTATGGCAATACGTTTCTTCAACATTGGTGGCGTGATGTCTTTAAAGTCGTCTTTCGAATATTTGACAACATGAAACTTCCTGATAGACAGATTGATTGGCAAGAGAAATCAGAGTGGATGACAACAACATGCAACCATGCTCTGTACGCTATTATTGATGTATTTACTCAGTATTTTGATATCTTGGCTGAAATTCTCTTGGATGATATGTACAGCCACCTTGAATGGTGTGTCAAACAAGATAACGAGCAGCTCGCGAGGTCTGGAACAAACTGTTTAGAAAATCTTGTGGTTTCCAATGGCAACAAGTTTTCAGAAGAGGTCTGGGAACAAACATGTCAGTGTGTCAAGACAATATTTGAGTCAACCGTACCTTATCGATTGTTAACGTGGAAACCCGTTAACCTTCAAGTATTGAATCTTCCTACTCCTGAATCTACCCCGGTTCCTTCTCCTATTAAGAAAATGCCTTCAGTTGACATGGAAGATGACATAGTACCAAAATACCCTGAAGATGAGGATGAATTTGATGGCGTATTGGAATCAACAGATGGAGTCGCTGAAGAAGAAGTGAGTTTGAATGAAGCTGTTGAAGAAACAAGTGAACAAGACAGTATTAGTTTACACAGTACACCAAGTTTACGTTTTGAACCTGTGGAGGACAAACCAATAATTCAAACGGAAAGAATGCTCTTCAATTCTCTGATCATAAAATGTGTAGTTCAGTTGGAACTTATTCAAATGATAGATAATGTCGTCTTCTATCCAAGTACAAGTAGGCGTGAGGACGAAGACAATATGGCGGAAATACGGGGTACAGCTGGACCTCGACGTGTTAATAAGCAAGGGCATGATGGAATGTTTCCACTTCTTAGCTCCAAACAGCTTTTCTTATTTTGTGAAGTTTTGGAAGAATCACATAAATTTGCTAAAAGTTTTAATTGTGATAATGACGTACGGACGGCCTTGTGGAAAGCTGGTTTCAAAGGTCAGTCGAAGCCCAACTTACTAAAACAGGAGACATCAAGTCTTGCTTGCTTGTTAAGAATTCTCTTCAGAATGTATGATGATGAAACCAGGAGAGATTCATGGCAGGATGTTGAGCAAAGAATGCTAAGAATATGCAGTGAAGCCTTACAGCACTTCAATCAATTACAATCATCAAGTCATAGAGATGCCTGGACGACATTGTTTGTTCTCATTTTTACCAGACTACTTCGTCTTGAAGATTCTAGGTTTAAAATTCACATTTCATCATGCTACCCACGCCTGTGTGAGATGGTCGTGTTGGATGGTACACTTGAACTCAAACTAATGTTACGCAAAGTTCTGCTGAGAACAGCAACTACATTTGGAATCATCAGCTCACAGAGTTAG

Protein

UniProt (Swiss-Prot top hit)

UniProt accession	Description
O46382	Brefeldin A-inhibited guanine nucleotide-exchange protein 1 OS=Bos taurus OX=9913 GN=ARFGEF1 PE=1 SV=1
Q9Y6D6	Brefeldin A-inhibited guanine nucleotide-exchange protein 1 OS=Homo sapiens OX=9606 GN=ARFGEF1 PE=1 SV=2
G3X9K3	Brefeldin A-inhibited guanine nucleotide-exchange protein 1 OS=Mus musculus OX=10090 GN=Arfgef1 PE=1 SV=1

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0002734 (this species only) · gene tree & orthology

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF16213 all species →	DCB	Mon2/Sec7/BIG1-like, dimerisation and cyclophilin-binding domain	Domain	Interproscan
PF12783 all species →	Sec7-like_HUS	Mon2/Sec7/BIG1-like, HUS domain	Domain	Interproscan
PF20252 all species →	BIG2_C	BIG2 C-terminal domain	Domain	Interproscan
PF01369 all species →	Sec7	Sec7 domain	Domain	Interproscan
PF09324 all species →	Sec7-like_HDS	Mon2/Sec7/BIG1-like, HDS	Domain	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR032629 all species →	Domain	Mon2/Sec7/BIG1-like, dimerisation and cyclophilin-binding domain	Interproscan
IPR000904 all species →	Domain	Sec7 domain	Interproscan
IPR016024 all species →	Homologous_superfamily	Armadillo-type fold	Interproscan
IPR023394 all species →	Homologous_superfamily	Sec7, C-terminal domain superfamily	Interproscan
IPR032691 all species →	Domain	Mon2/Sec7/BIG1-like, HUS domain	Interproscan
IPR046455 all species →	Domain	Sec7/BIG1-like, C-terminal domain	Interproscan
IPR035999 all species →	Homologous_superfamily	Sec7 domain superfamily	Interproscan
IPR015403 all species →	Domain	Mon2/Sec7/BIG1-like, HDS	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR10663 all species →	GUANYL-NUCLEOTIDE EXCHANGE FACTOR	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0005085 all species →	Molecular Function	guanyl-nucleotide exchange factor activity	Interproscan
GO:0032012 all species →	Biological Process	regulation of ARF protein signal transduction	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

KO	Enzyme	Enzyme ID	Pathway	Map ID	Source
K18442	ARFGEF, BIG; brefeldin A-inhibited guanine nucleotide-exchange protein	-	Membrane trafficking	ko04131	deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Co-expression network

Genes whose expression across the transcriptome samples of Eunicella cavolini tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

No co-expression network has been built for this species, so this gene has no partners to show. Networks are available for the species listed on the Network Analysis page.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Eunicella cavolini, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

Analysis	What it does	Status
Primer design	Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.	template found	open →
BLAST	Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.	template found	open →
Expression heatmap	Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.	no expression matrix	–
Gene family / orthogroup	Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.		open →
Gene set analysis	Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.		open →