Gene detail

Detailed information of ENSLDHP00000049186.1 in Eunicella cavolini

Genomic Location: chr9:5155267...5199163
NR annotation: XP_028407284.1, regulator of telomere elongation helicase 1-like [Dendronephthya gigantea]
Species Eunicella cavolini · all data for this species · gene families

Gene Structure

More details in JBrowse

Sequence

CDS

ENSLDHT00000054026

atgcacatagGCCCAGAACTCATAATTCAGTGTATACTAGAAGTGTTATCTGGCCACCATCCTGTAACTGGCCAGGAAACAATAAAACCATCCAATTTATTGCAGGGTAAAAATGGGATTCTTGAATCACCCACTGGAACTGGAAAGACGTTATGTTTACTTTGTGCAACGCTGGCCTGGCGTGAGACGTATATCGCCCACTTGCAGCTGAGCGTGAAAGTTCAGGAGAATAAAGCAAGTGGTCAGTATTGTGATATCTTGCAAGAAAACCTTGGACAAGCAGCTGTTGGGTGGACCTCAGACGAAGATAATGCTCCTGAATACGATGTTCCCAAAATCATCTACACATCAAGAACACATTCTCAACTTACACAGGCAGTTAATGAACTCAAGAATACAATATACAAACCCAAAGTATGCGTGTTAGCATCACGTGAACAATTATGTATTCATCCTCAGGTTCTTGAACAAGAAACGAACACAGCCAAGatgcaCATGTGTCGTACAAAAGTAGAAACGaaaaaatgtcatttttatAATAACTTGGAACAAGTAATCAATATGTTTATTACTATTTTTAGTCGTTGCCCTTATTACATGTCTCGAAATCAAAAGAAAGTTGCAGATATTGTGTTTATGCCTTATAATTATTTAATTGATGCTAAGTCAAGAAGTGCAAACGGTATTGACATCTCCAAAAGTATAATTCTGTTTGATGAAGCGCACAATATAGAACGTATTTGTGAAGAAGCAATGTCGTTTGATCTTACTTCGTTTGATATCGCAAGTTGTATCGAAGATCTTGATAAATGTTTGGATACTTTATCTAACATGGAGGAAGATGGGACATTGTCATTGTTGATCTCATTATTttttattgacatattttatAGTTATGTATTTGAATTGCTGACGAAAGTCAAAATCACACATGAAACCCAAAAACAGGTCCTTGATCTGATTGAAAAAATCTGTACATTTTTGGTCGCAAGTAAGTTCTGTTTTTACACACAGTTGCACAAAGCATACGTGGCTACATGCGTCCATATTCAACAGCGAGTAGATGATAGCTCAAAGAAGAAACAACTTGACGTATGGTCAACTAGCAAAGCTACAAGTAGCAAGCAAGGTTATTCTCTGGGCTACTGGTGTTTCTCTCCTGGGGAGACAATGAAAGATTTAATGAAAAATAATGTTAGATCGATGATCTTAACCAGTGGAACACTGTCCCCAATACAATCTTTTAAAGCTGAACTACAAATTGACATACCGGTAGAGCTTCAAAATCCGCATGTGATCAAGAAACATCAGATGTTTGTTGGAGTTTTAAAAGCAGGGCCTGATGCGGTTGTCCTCAATTCCTCATTCAAAAACAGGAACAGTGAAAAGTACCTGACCAGCCTTGGAAATGCAATAGTAAATTTTGCCCAGATTGTTCCTGACGGGATGTTGGTATTTTTTTCATCGTATGGAACTCTGGATACATCTTTGAAACATTGGcagGCCACTGGTCTATGGAACAGACTTGAGAGCCGCAAAGCAATCTTTGTTGAACCGAGAAGAAAGGTCGAATTCACAGAGGCAATGGAAGGATTTTATGAGAAAATAAAAAACCCAGATAATAAGGGAGCTGTGTTCCTTGCCGTATGCAGAGGAAAGGTGAGCGAAGGTGTTGATTTTAGTGATATCAATGGTCGTGCAGTCATCATTACTGGATTACCTTATCCTCCGGCTTTTGACGCAAGGGTGAAATTGAAACAACAGTTTTTAGATGAAGTGAAAAACAAAAGGGCGTTTAAGGGTTTAACTGGTAAGGAGTGGTATAAACAACAAGCATCACGAGCCGTCAATCAAGCAGTTGGTCGCGTTTTACGTCATAAAGAAGATTTTGGCGCCATTCTTTTTTGTGATGAAAGGTTTACGTTCACGTCAAACACAGCAGAACTGCCGAAATGGATGAAACcgtatataaatatttattcaaattttggCGAACTTCAAAAGCAATTACGACAGTTTTTTAGGCGGGCTACTGAATTGGTAAGtcctaaaataaaatattattgcgATAACTTTCTAAATGGTGGACAATACCAGTATAAATTAATGCATACTTTTATACGATTCCTGTGTCCAAGGGACATTGTGCGAAATATACTATAtagaattttaaaaatgtgcTGGTTCGCATGTGTGTTTGTGTTTATAATATTTCTAAGCATTCGCTTTCAGTGTGATTCAAGATGTATGAAAGTCAAGAAGCTGACTAAAGAAGAAGAAATTATTGCCACTACTGACGATGCGAaatgtgaaaatgaaaatcaCTGGCTACCTGAAACTGCTATTTCAGAGTCCAAGAACAGTAGCAAACCTAAATTTTCTAAAGAAGAGATTGCTAAGAAGCGAATTGATAGACGTAAGTTTGAGGTTTCTTTAACTTTAGTGTCCTTATTTCGCATGGTTGGGTCAGGGTTATTTACCTATCAACGTTTAAATTATATAGTCACTTTTCAGCATGAATAA

Protein

UniProt (Swiss-Prot top hit)

UniProt accession	Description
Q9NZ71	Regulator of telomere elongation helicase 1 OS=Homo sapiens OX=9606 GN=RTEL1 PE=1 SV=2
Q0VGM9	Regulator of telomere elongation helicase 1 OS=Mus musculus OX=10090 GN=Rtel1 PE=1 SV=2
A4K436	Regulator of telomere elongation helicase 1 OS=Bos taurus OX=9913 GN=RTEL1 PE=2 SV=1

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0001291 (this species only) · gene tree & orthology

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF13307 all species →	Helicase_C_2	Helicase C-terminal domain	Domain	Interproscan
PF06733 all species →	DEAD_2	DEAD_2	Family	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR045028 all species →	Family	Helicase superfamily 1/2, DinG/Rad3-like	Interproscan
IPR027417 all species →	Homologous_superfamily	P-loop containing nucleoside triphosphate hydrolase	Interproscan
IPR006555 all species →	Domain	ATP-dependent helicase, C-terminal	Interproscan
IPR013020 all species →	Family	ATP-dependent helicase Rad3/Chl1-like	Interproscan
IPR010614 all species →	Domain	RAD3-like helicase, DEAD	Interproscan
IPR006554 all species →	Domain	Helicase-like, DEXD box c2 type	Interproscan
IPR014013 all species →	Domain	Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR11472 all species →	DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0003678 all species →	Molecular Function	DNA helicase activity	Interproscan
GO:0005524 all species →	Molecular Function	ATP binding	Interproscan
GO:0005634 all species →	Cellular Component	nucleus	Interproscan
GO:0010569 all species →	Biological Process	regulation of double-strand break repair via homologous recombination	Interproscan
GO:0032508 all species →	Biological Process	DNA duplex unwinding	Interproscan
GO:0045910 all species →	Biological Process	negative regulation of DNA recombination	Interproscan
GO:0070182 all species →	Molecular Function	DNA polymerase binding	Interproscan
GO:0090657 all species →	Biological Process	telomeric loop disassembly	Interproscan
GO:1904430 all species →	Biological Process	negative regulation of t-circle formation	Interproscan
GO:0003676 all species →	Molecular Function	nucleic acid binding	Interproscan
GO:0004386 all species →	Molecular Function	helicase activity	Interproscan
GO:0006139 all species →	Biological Process	nucleobase-containing compound metabolic process	Interproscan
GO:0016818 all species →	Molecular Function	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	Interproscan
GO:0003677 all species →	Molecular Function	DNA binding	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

KO	Enzyme	Enzyme ID	Pathway	Map ID	Source
K11136	RTEL1; regulator of telomere elongation helicase 1	EC:5.6.2.3	DNA replication proteins	ko03032	deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Co-expression network

Genes whose expression across the transcriptome samples of Eunicella cavolini tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

No co-expression network has been built for this species, so this gene has no partners to show. Networks are available for the species listed on the Network Analysis page.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Eunicella cavolini, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

Analysis	What it does	Status
Primer design	Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.	template found	open →
BLAST	Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.	template found	open →
Expression heatmap	Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.	no expression matrix	–
Gene family / orthogroup	Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.		open →
Gene set analysis	Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.		open →