Gene detail

Detailed information of ENSODKP00000003058.1 in Millepora complanata

Genomic Location: chr1:207998224...208022967
NR annotation: XP_047125773.1, NAD-dependent protein deacetylase sirtuin-1 isoform X1 [Hydra vulgaris]
Species Millepora complanata · all data for this species · gene families

Gene Structure

More details in JBrowse

Sequence

CDS

Transcript

ENSODKT00000003058

AGTTAAGCACTTTTAGAAAccttatatttcatattttgaatgaaacttgTACGTGTGGACATCGGAATGGCAACTGCAGGAAATACAGAAGATGAAGAACGAAATAATTTGGGCAGCATAGAAGACAAAGAGCTCAAAGAGACAAGACAGAGTTTCCGCAGAGATCCAACAATGTGGGTACATCGGCAAATAGAAAATGGGGTTGAAGCAAGGCAAGTTCTCCAACGACTAATACCAGAAGTTACAATACCAGAACAAGTGAACGAATTGTCTTTGTGGAGGCTGGTGCTTGAGATTCTATCTGAACCTGCACCCCGAGAGCAGCTAAGACACGTCAACTCGATTGAGGATGCCAAGCGATTGATCCAAGAATGTAAAAATATCGTTGTGCTCACTGGAGCGGGGGTTTCAGTATCGTGTGGAATTCCTGATTTTCGTTCGCGTGATGGTATTTATGCGAGACTGAGTAAAGATTATCCAGATCTACCAGACCCACAAGCTATGTTTGACatacattattttcatcataatcctTGGCCATTCTTTAAGTTTGCAAAGgaaatctaCCCTGGTCAATTTACACCGTCACTATGTCACAGATTTATAGCACATCTGGACAAGCAAGGCAAATTGTTGCGTAATTACACGCAAAATATTGATACTCTTGAACAAGTGGCTGggataaaaaatattgtgcaaTGTCATGGTTCTTTTGCCACAGCTAGTTGCTTGAATTGCAAGGCAAAAGTTACTGCAGATGCTGTCAAAGAAGACATTTTTCAACAGAAAATCCCGTATTGCAGAGAGTGTACTGTAGAGGAGAATTCTGGCAGGACAAACATTTTAAAGCCAgATATTGttttctttggtgaaagtttGCCCGATCATTTTCACAAGCAAATCGAACTTGATAAAGACAAGGCTGATCTTCTGATAGTCATTGGATCTTCTCTTAAAGTGCGACCAGTTTCACTGCTTCCCAatttagtaAACCCCAATATACCTCAAATTTTAATCAATCGCGAACCACTGCATCATCATAAATTTGACATCGAATTCTTTGGAAATTGTGATGACGTTATATCTGAATTGTGTAATCAGTTAGGTGGGGAGTGGACTAATGTAACTCAATCATTTAAGCAGTCGCCAATAGAAAAGCATATTATACAGAAAATGTTCGCTGATGCCAAGGCCATGTTCGAATCGGGGGAAGATTCTTCAAATGATTCAAATGATATACCAGAAAATTTGCAGGTATTGCCAAATAAAGTGAATGGTTTACCCAATGGATTCTCAAACAATGAACCACCAAACAGTCTTGCAGGAAACAATCCAGATGATAACATCCAAGATGATCTAAAAGATACCAGCAATAGAGCCATTTCTAGTGATCTGGAAAATGTCAACTCGGGAAGTGACGAAGGGCGAGTTAGTTCTCCCTCgtctgataaatctttaaaaagacgTAAAGAAACTTTAGAAGAAAGGGAATTAACGAAAAGAATAAGGAATCAGTCTatcagtgaaaaagaagaaagtaaagAGTCAATTTTTTATCTTCCGATACCTCCAAATCGCTACATTTTCCACGGAGCAGAACTTGAATACTTCGACAGTGACACAGACAGTGATGATGAGCAAGgagattttgaactttttaatgaagttgaaaCCTCACCAGaacataaaaatattgttaataatacaAATCATCAAATTGTGCAAAGTTCAAGTAACTCTTCTGCTCGTGTTCATcaagatgaaaaaattagaaatattgtttCATTGCAAACAAATGACAGAGAAGCTCATAATATAACTCCAACAATTAAAGAGAGCTATGGACAACATGAAAATCTTGACAGTGTTGATACAAAGCAAACTGAACCAATAGGTACTATCGAGCAAATTGATCCCTTAGGAAAGCCATAATATCCCAAACGGTTATAGCCGACTAATTGCGAGGGATGCCCTAACGAAAGAGTAAACGAGAAAAGCAGAAACATTAAAGATAAGTTGACGATTCAAAACCTGTGACTTAAACGAATGAGTAGCAGATtaggataaataaaaaaagttgggATACCAATATATTAATTAGAATATATAGGACGAAAGCAGCAATAGGACTTTGCATATAGTCTTTTGcgataaatacttttttataatatagctttaataaaatttttcttctaacaTTGAGCGAAttttttaagcgaattaattaacttttattcccccctgaaatcattaaaaaacctatggctttctgacgatttcagagataatagaaaatgaattaattcgcttgaattttCTTGaatgttagaagtgaaatttagagCTAGTCCCTAATCAAACTCGGAAAAACCAAAGCGCATTTGATGCAGTGGACATTGAAAAAGATTCATACACTTAGACATGTAAATTTAGACAGATTCAACTGTTTTAGGAAACCCAAGTAATCTAACCTTCAAGAAACTTTCATCAAGAGTTCGTGCAGATTACTtagtttttcattgaaaaaatagatggatacTATA

Protein

UniProt (Swiss-Prot top hit)

UniProt accession	Description
A0A0G2JZ79	NAD-dependent protein deacetylase sirtuin-1 OS=Rattus norvegicus OX=10116 GN=Sirt1 PE=3 SV=2
Q923E4	NAD-dependent protein deacetylase sirtuin-1 OS=Mus musculus OX=10090 GN=Sirt1 PE=1 SV=2
Q96EB6	NAD-dependent protein deacetylase sirtuin-1 OS=Homo sapiens OX=9606 GN=SIRT1 PE=1 SV=2

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0005974 (this species only) · gene tree & orthology

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF02146 all species →	SIR2	Sir2 family	Family	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR026591 all species →	Homologous_superfamily	Sirtuin, catalytic core small domain superfamily	Interproscan
IPR026590 all species →	Domain	Sirtuin family, catalytic core domain	Interproscan
IPR003000 all species →	Family	Sirtuin family	Interproscan
IPR029035 all species →	Homologous_superfamily	DHS-like NAD/FAD-binding domain superfamily	Interproscan
IPR050134 all species →	Family	NAD-dependent sirtuin protein deacylases	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR11085 all species →	NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0070403 all species →	Molecular Function	NAD+ binding	Interproscan
GO:0002039 all species →	Molecular Function	p53 binding	Interproscan
GO:0003714 all species →	Molecular Function	transcription corepressor activity	Interproscan
GO:0005634 all species →	Cellular Component	nucleus	Interproscan
GO:0005637 all species →	Cellular Component	nuclear inner membrane	Interproscan
GO:0005654 all species →	Cellular Component	nucleoplasm	Interproscan
GO:0017136 all species →	Molecular Function	histone deacetylase activity, NAD-dependent	Interproscan
GO:0033553 all species →	Cellular Component	rDNA heterochromatin	Interproscan
GO:0045892 all species →	Biological Process	negative regulation of DNA-templated transcription	Interproscan
GO:0070932 all species →	Biological Process	obsolete histone H3 deacetylation	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

KO	Enzyme	Enzyme ID	Pathway	Map ID	Source
K11411	SIRT1, SIR2L1; NAD-dependent protein deacetylase sirtuin 1	EC:2.3.1.286	Mitochondrial biogenesis	ko03029	deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Co-expression network

Genes whose expression across the transcriptome samples of Millepora complanata tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

No co-expression network has been built for this species, so this gene has no partners to show. Networks are available for the species listed on the Network Analysis page.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Millepora complanata, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

Analysis	What it does	Status
Primer design	Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.	template found	open →
BLAST	Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.	template found	open →
Expression heatmap	Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.	no expression matrix	–
Gene family / orthogroup	Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.		open →
Gene set analysis	Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.		open →