Gene detail

Detailed information of ENSOFVP00000023070.1 in Cyphastrea salae

Genomic Location: chr4:32845262...32860257
NR annotation: XP_022785612.1, methylmalonyl-CoA mutase, mitochondrial-like [Stylophora pistillata]
Species Cyphastrea salae · all data for this species · gene families

Gene Structure

More details in JBrowse

Sequence

CDS

Transcript

ENSOFVT00000024878

GGTATCGACATCAAGCCTGCATACACCAAAACTGATACTCAACATACTGAAGAGGAGATTCCAGGAAAGTTTCCATTTACTAGGGGACCCTACCCCACTATGTACACAAATCGACCTTGGACCATCCGTCAGTATGCAGGTTTCAGTACTGTTGAGGAGAGCAACAAGTTTTATCGTGACAACATCAAGGCTGGCCAGCAGGGACTCAGTGTCGCATTTGATCTGGCCACTCATCGAGGGTATGACTCAGACAACCCAAGAGTTCATGGTGATGTTGGAATGGCTGGTGTTGCTGTTGATTCAGTGGAGGACATGAAGATGTTGTTTGATGGCATCCCTCTGGATAAGATGTCAGTTTCCATGACAATGAATGGTGCTGTTTTACCAGTGTTAGCAATGTATATTGTGGCAGCAGAAGAACAGGGAGTAAAACAAGAACAGCTATCAGGGACCATTCAGAATGACATCCTGAAGGAGTTCATGGTGCGCAACACCTACATCTTCCCACCTGAGCCATCCATGAAGATCATTGGCGATATCTTCTCCTACACTTCACAGAATATGCCAAAGTACAACAGCATCTCAATCTCTGGTTACCACATGCAAGAAGCAGGAGCAGACGCCGTACTGGAGATGGCTTTCACTTTAGCTGATGGTCTAGAATACTGCAGAACAGGTCTTAAAGCTGGACTCAATATCGACAGCTTTGCACCTCGCCTGTCGTTCTTCTGGGGAATTGGAATGAATTTCTACATGGAGATAGCAAAGATGAGAGCTGCGCGTAGACTGTGGGCCAATCAGATTGAAGAGAACTTCAAGCCAAAAAACATGAAGTCGTGTATGTTGAGGACACATTCGCAGACTTCCGGTTGGTCTCTCACTGAACAGGATCCATACAACAATATTGTCCGTACGACAATCGAAGCCATGGCAGCGGTGTTTGGTGGAACCCAGTCCTTGCACACCAACTCGTTCGACGAGGCCCTGGCACTACCGACTCCTTTTAGCGCAAGGATTGCTCGTAACACGCAGATCATACTGCAAGAGGAGTCTGGCATTCCTAATGTTGCAGACCCGTGGGGTGGTTCATACATGATGGAATGTCTCACAGACGAGATATACGAAAAGGGTTTGAGTGTTATCAAAGAGGTGGAAGAGTTGGGAGGCATGGCCAAAGCAGTCGCCGCAGGAATGCCAAAACTGAGGATCGAGGAATGTGCAGCCAGACGACAGGCCAGGATCGACTCAGGGTCAGAAACAATCGTTGGCGTTAACAAGTATCGGTTGGCCAAAGAAGAAGCCATTGAtgtactcgttgtcgataaCACCAGAGTGCGAGAACAACAGTTGGAGAAAATAAAGCGAATTAGAGAGACCCGAAACCAGGATGAGGTGAATTTGGCGATGGATGCCATCTCTGAGTGCTGCAAAACAGGACAAGGGAATCTTCTAGACCTTGCTATTAAGGCTTCCAGGGTACGTTGCACAGTTGGGGAGATAACCGAAGCAATGGAAAGGgtgGTTGGAAGACATGTCGCCAGTGATCGCATGGTCAGCGGTGCCTATAAGACAGAATTTGGCGATTCGGACGAGATAAGCCAGTGCATGAGGAAAGTGAATGCTTTTGTGGAACAGGAAGGCCGTCGACCTAGGATCCTGGTGGCGAAAATGGGCCAGGATGGACACGATAGAGGTGCTAAGGTGATCGCTACAGGATTCGCTGATCTTGGGTTTGATGTCGACATTGGACCACTTTTCCAGACTCCCATGGAAGTTGCGCAGCAGGCGGTGGACGCGGATGTACACGTAGTGGGAATTAGTTCCCAGGCTGCAGGACACAAAACTCTCCTTCCCGAGTTGATAGCACAGATGAAGTCAATGGGAAGAGGTGATATCGTCGTCGTGTGTGGTGGTGTTATTCCTCCTCAAGACTATCAGTTCCTTTATGACTCCGGAGTCAACTGTATCTTCGGCCCAGGAACACGCATTCCGGCGGCAGCTATGGATGTCTTGGATGCTGTAATGAACGGTAACGCTGGACAAAAGACCACCGCTTAGACTACTGGACCTACAACAGCTAGCGTAATTCTAAAACTCTTTTCTAGCGGCCCTGTTTAGAAACAGTCAAGAAAATCATTACTGTAGTGAGCCTGCGATTTTCTACAGCGGTGTTGCCAAGTAACCATGACATCCGACTCTTAATAGCAGCTTCACGCAATCACTTTGCATGAACTGCATATTAAACGTATTGTTTTAGTAATTTTCATGAAAGTAAATTTTTTCTTGAATTTGAGCCAGACCAAGTTATGCATTTAGCCCTGGTAGTTTAAATGTGAACTGTGCGTGTGCTGTTCGTGTGGTCGCTGTATGGCTGGCAGTAATTTCGGATCACTCGCGATATTTTCGAAATCGATAATCTTTTGGGAATTTTGTTGTTATGCTTGCGCGAGGTTTACTCAAATGACAACGGGCTTACGGTaaaaatcaagagaaaatgaggggacagagaAGGAAGCTCCCTGTCCATCCCTGGGGATATGTCATGTCcacgaaagttatttttagaagaGTGGAAGTCTTTTTTTTAGCGGAAGTCTGTCTTCTGAGACGTCCGCATGCATGCCAACTTCGGTTTGATGTACGTGCGCCGCcattttctcttttcactaagAACCTGAGAGCGAGGCAAAACTGCAAGTGGACGTCTCGGAAGACAGTCTTCCGCTAAAACAAAGACTTCCgctcgtctaaaaataactttcgtgGATATGACATATCCCAACGCCCTGAGCCTCCCTCTCTGTCcgctcattttctcttgattctTACCATGAGCCCGTTGTCATTTGATGATGCGGTCGACAATTGAAGGTTGTGAGCTCATGTTTGACGTCTAAACTGTAAATAAGAACGTCTTAGAAACAAATTAAGGTATAATTATTCCTAGTCTGGTTTTAGAAACCTGTTAACAGGGATAGAGAGATTACCTGACGATAAAAATAACTTGCTGAAAAAGTGGCTGAATGGATGAAattcatgtaaaaaaaaagcagaGCC

Protein

UniProt (Swiss-Prot top hit)

UniProt accession	Description
P16332	Methylmalonyl-CoA mutase, mitochondrial OS=Mus musculus OX=10090 GN=Mmut PE=1 SV=2
P22033	Methylmalonyl-CoA mutase, mitochondrial OS=Homo sapiens OX=9606 GN=MMUT PE=1 SV=4
Q5RFN2	Methylmalonyl-CoA mutase, mitochondrial OS=Pongo abelii OX=9601 GN=MMUT PE=2 SV=1

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0003934 (this species only) · gene tree & orthology

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF02310 all species →	B12-binding	B12 binding domain	Domain	Interproscan
PF01642 all species →	MM_CoA_mutase	Methylmalonyl-CoA mutase	Family	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR006158 all species →	Domain	Cobalamin (vitamin B12)-binding domain	Interproscan
IPR036724 all species →	Homologous_superfamily	Cobalamin-binding domain superfamily	Interproscan
IPR016176 all species →	Homologous_superfamily	Cobalamin (vitamin B12)-dependent enzyme, catalytic	Interproscan
IPR006099 all species →	Domain	Methylmalonyl-CoA mutase, alpha/beta chain, catalytic	Interproscan
IPR006159 all species →	Domain	Methylmalonyl-CoA mutase, C-terminal	Interproscan
IPR006098 all species →	Domain	Methylmalonyl-CoA mutase, alpha chain, catalytic	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR48101 all species →	METHYLMALONYL-COA MUTASE, MITOCHONDRIAL-RELATED	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0031419 all species →	Molecular Function	cobalamin binding	Interproscan
GO:0046872 all species →	Molecular Function	metal ion binding	Interproscan
GO:0004494 all species →	Molecular Function	methylmalonyl-CoA mutase activity	Interproscan
GO:0005737 all species →	Cellular Component	cytoplasm	Interproscan
GO:0005739 all species →	Cellular Component	mitochondrion	Interproscan
GO:0019678 all species →	Biological Process	propionate metabolic process, methylmalonyl pathway	Interproscan
GO:0003824 all species →	Molecular Function	catalytic activity	Interproscan
GO:0016866 all species →	Molecular Function	intramolecular transferase activity	Interproscan
GO:0016853 all species →	Molecular Function	isomerase activity	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

KO	Enzyme	Enzyme ID	Pathway	Map ID	Source
K01847	MUT; methylmalonyl-CoA mutase	EC:5.4.99.2	Cobalamin transport and metabolism	ko04980	deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Co-expression network

Genes whose expression across the transcriptome samples of Cyphastrea salae tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

No co-expression network has been built for this species, so this gene has no partners to show. Networks are available for the species listed on the Network Analysis page.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Cyphastrea salae, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

Analysis	What it does	Status
Primer design	Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.	template found	open →
BLAST	Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.	template found	open →
Expression heatmap	Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.	no expression matrix	–
Gene family / orthogroup	Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.		open →
Gene set analysis	Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.		open →