Gene detail

Detailed information of ENSOJPP00000013980.1 in Anthopleura xanthogrammica

Genomic Location: chr10:8158781...8166098
NR annotation: XP_031559843.1, inactive tyrosine-protein kinase transmembrane receptor ROR1-like isoform X1 [Actinia tenebrosa]
Species Anthopleura xanthogrammica · all data for this species · gene families

Gene Structure

More details in JBrowse

Sequence

CDS

ENSOJPT00000016144

AATACAACTGTAGTTTCATTCTGGTTGTATATGGATGGTTCTCCAGTTATCAGCACCAGCCTGCTTAATGAAACCACAGAAGTAGGAAAAAAGAGTGTTTTAAAATGTGTGGTAACTGGGTCACCGACACCAGACATAACGTGGTACAAGGGTAGTATTAATCTACACAACACCCAAAAAGGAAGAATTGCAATAAAAAGACTTGACTGGGGATCTCGGTTAAAGATCAAAACTTTACGAGTATCAGATACTGGCAGATACTTTTgtcaagcaaaaaataaagctGGGGTTGCTGTAAGCAATACTGCACACATTGTTGTCAGAGaTGGCAGTTGTTTTAATGGCTCTGGAGAAAATTATAGAGGCAGTATAAACATAACAGCGAATGGTTATACTTGTCAACAATGGAATACCACTTCCACCTACCCAGAGTTACAAGGTGGTCATAATTTCTGTCGGAATCCTGGAGGGCAGAAGAAAGGTCCTTGGTGTTTTACCACAGATCCTAACAAGAGATATGATTACTGCGGCATTGCACAATGTGAAGAAACCAAATCCCAACCATCGACTACAGCAGCCACTACTGAAAAACATGTTGGCCATGCAGAATTCACCTATCCAGCCCCCACTGCACACCCAGGATACTGTGTTCGCTACACAGGAAGCAAATGCTCTTCCTACATCAACCGTCGAAAGACCGTGTACATAAAAGCTGTCAACCAGCAAAGCTCCATAGAAAAGAAACTAGAAATTGCACTAAATgcgatatcatcatcaaagaAACTAAGCGACAGGTGCAAGCCATATGTACTGCCTCTTCTGTGCCATTACTTGTTCCCCTATTGTGATGATGTAGCCACAGAACCCAAACCAAGACCAATATGTTATGAAGAATGCGACTTGTTAAGGAAAGACATCTGTCGAGATGAGTATATAGTCGCCAAGAGAGAGTCTTTGGAACACGTTTTATTCCCTGATTGTTCTTTGTTGCCGATGAAGGAAagcaaagaaggaaagaacTGTATTCCACTGAGGTTGCCGTTTACTAGAGGAGTCAGGTTTAGGGAAAAGAAAGGCGATCGTTGCTTTAACGGCACAGGTGAACATTACCAAGGCAACGTCAGTGTGACCGAGAAGGGATACTCGTGTCAGCGTTGGAACTCCACTGAACCGCACTACCACTTAATGTCGCCTGCTGTGCATCATGAGCTGCGTGGTGGTCATAACTTCTGTCGGAATCCTGGAGGAAAGAAGGATCGACCTTGGTGCTTCACCACCGATCCTAAGAAGAGATACGACTACTGTGCTATTGCGCGCTGCGAAGAAGACCCGCCCACGATCCATGTGGTCAGCATCTTGTACACAGTAATCCCATGTCTTATCATCGCTATTGTGTTTTCGTCTGTGGTCATCTTCATCTGTTGGAGGTGTCACAAACAAATCATTTACAATGCCAATCAAACGGCCACGCCCCTTATGCCCGTCACTGTCAAGACGGTTTCCAAGatgcaagaaatgaaagaatctCTCCATCTTTTAAAAGAACTTGGAGAAGGAGAGTTTGGAAAGATATATCACGGAGAAATCTCCACACGGCAAGACAATAAAATGGTCGTCACTCAGGTCCTCATTTCGGGGCTGAGAAAATCACACGACCAAACTCAAAGACAAGAGTTCCTCgatgaaaaagaaacttgGCTTAAATTCGCGCACCCGAATGTCCTGCCTATTCTGAGTATTCTCGACCAGGGGCACCCGGCTTATGTACTCTACGAGTATCTAGAATGCGGCACACTTCATGAGTACTTGATCCGACACGCACCCATCGATGATGCGCTCGAAGACAGTGAAGATTCGGCAACTCTTTGGTGCTACGACTTATTATCGATTGCGTACCAGATCGCGGCGGGCATGAATTATCTATCTGATATTGATTATGTTCACGGAGATCTAGCTACGAGAAACTGTATGATAGGGTCGAGATTTGAAGTGAAGATAACCGATCTGGCTGCAACGCGATCGGGGTATGCGCATGACTATTATCGATTACCCAACAGGCGTCCGCTACCCGTACGTTGGATGGCTCCCGAGAGCATCATTAGCTATAGATTCACTACAGAATCAGATATATGGTCCTTTGGGGTGGTTCTGTGGGAGCTCTTTTCGTACGGTGCTCAGCCATACTATGGTTTATCGAACGAGGACGTCATGCATCGGTTCAGAGAGTTCGTACTCTTGCCGTGCCCGTTAGACTGTCCGGCCAGCGTGTATTCCCTAATGAACGACTGCTGGAATATTCTTCCTCCAAGCAGACCGAGGTTCAGCTCGATCTACAAGATTTTATGCGCTTTAAGATGCGAAAGTACTTTTCCAGCGTTGCCAACGTGA

Transcript

ENSOJPT00000016144

Protein

UniProt (Swiss-Prot top hit)

UniProt accession	Description
Q01973	Inactive tyrosine-protein kinase transmembrane receptor ROR1 OS=Homo sapiens OX=9606 GN=ROR1 PE=1 SV=2
Q9Z139	Inactive tyrosine-protein kinase transmembrane receptor ROR1 OS=Mus musculus OX=10090 GN=Ror1 PE=2 SV=2
Q01974	Tyrosine-protein kinase transmembrane receptor ROR2 OS=Homo sapiens OX=9606 GN=ROR2 PE=1 SV=2

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0001762 (this species only) · gene tree & orthology

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF07679 all species →	I-set	Immunoglobulin I-set domain	Domain	Interproscan
PF01392 all species →	Fz	Fz domain	Domain	Interproscan
PF07714 all species →	PK_Tyr_Ser-Thr	Protein tyrosine and serine/threonine kinase	Domain	Interproscan
PF00051 all species →	Kringle	Kringle domain	Domain	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR036179 all species →	Homologous_superfamily	Immunoglobulin-like domain superfamily	Interproscan
IPR041775 all species →	Domain	Ror-like, cysteine-rich domain	Interproscan
IPR007110 all species →	Domain	Immunoglobulin-like domain	Interproscan
IPR013806 all species →	Homologous_superfamily	Kringle-like fold	Interproscan
IPR013098 all species →	Domain	Immunoglobulin I-set	Interproscan
IPR020067 all species →	Domain	Frizzled domain	Interproscan
IPR008266 all species →	Active_site	Tyrosine-protein kinase, active site	Interproscan
IPR000001 all species →	Domain	Kringle	Interproscan
IPR038178 all species →	Homologous_superfamily	Kringle superfamily	Interproscan
IPR018056 all species →	Conserved_site	Kringle, conserved site	Interproscan
IPR001245 all species →	Domain	Serine-threonine/tyrosine-protein kinase, catalytic domain	Interproscan
IPR036790 all species →	Homologous_superfamily	Frizzled cysteine-rich domain superfamily	Interproscan
IPR003598 all species →	Domain	Immunoglobulin subtype 2	Interproscan
IPR050122 all species →	Family	Receptor Tyrosine Kinase	Interproscan
IPR013783 all species →	Homologous_superfamily	Immunoglobulin-like fold	Interproscan
IPR011009 all species →	Homologous_superfamily	Protein kinase-like domain superfamily	Interproscan
IPR003599 all species →	Domain	Immunoglobulin subtype	Interproscan
IPR000719 all species →	Domain	Protein kinase domain	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR24416 all species →	TYROSINE-PROTEIN KINASE RECEPTOR	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0005515 all species →	Molecular Function	protein binding	Interproscan
GO:0004672 all species →	Molecular Function	protein kinase activity	Interproscan
GO:0006468 all species →	Biological Process	protein phosphorylation	Interproscan
GO:0004714 all species →	Molecular Function	transmembrane receptor protein tyrosine kinase activity	Interproscan
GO:0005887 all species →	Cellular Component	plasma membrane	Interproscan
GO:0007169 all species →	Biological Process	cell surface receptor protein tyrosine kinase signaling pathway	Interproscan
GO:0007275 all species →	Biological Process	multicellular organism development	Interproscan
GO:0010976 all species →	Biological Process	positive regulation of neuron projection development	Interproscan
GO:0014068 all species →	Biological Process	obsolete positive regulation of phosphatidylinositol 3-kinase signaling	Interproscan
GO:0017147 all species →	Molecular Function	Wnt-protein binding	Interproscan
GO:0033674 all species →	Biological Process	positive regulation of kinase activity	Interproscan
GO:0043235 all species →	Cellular Component	receptor complex	Interproscan
GO:0005524 all species →	Molecular Function	ATP binding	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

No KEGG orthology assignment for ENSOJPP00000013980.1.

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Co-expression network

Genes whose expression across the transcriptome samples of Anthopleura xanthogrammica tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

No co-expression network has been built for this species, so this gene has no partners to show. Networks are available for the species listed on the Network Analysis page.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Anthopleura xanthogrammica, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

Analysis	What it does	Status
Primer design	Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.	template found	open →
BLAST	Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.	template found	open →
Expression heatmap	Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.	no expression matrix	–
Gene family / orthogroup	Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.		open →
Gene set analysis	Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.		open →