Genomic Location: chr6:10223660...10264777
NR annotation: XP_031573677.1, E3 ubiquitin-protein ligase HUWE1-like isoform X1 [Actinia tenebrosa]
Species Anthopleura xanthogrammica · all data for this species · gene families
| CDS |
| ENSOJPT00000021268 |
| Transcript |
| ENSOJPT00000021268 |
| Protein |
| ENSOJPP00000018352.1 |
| UniProt accession | Description |
|---|---|
| Q7Z6Z7 | E3 ubiquitin-protein ligase HUWE1 OS=Homo sapiens OX=9606 GN=HUWE1 PE=1 SV=3 |
| Q7TMY8 | E3 ubiquitin-protein ligase HUWE1 OS=Mus musculus OX=10090 GN=Huwe1 PE=1 SV=5 |
| P51593 | E3 ubiquitin-protein ligase HUWE1 OS=Rattus norvegicus OX=10116 GN=Huwe1 PE=1 SV=3 |
| Family type | Membership / link |
|---|---|
| Orthogroup (gene family) | OG0002395 (this species only) · gene tree & orthology |
| Ubiquitin family | E3|E3 activity|HECT · all ubiquitin genes in this species |
| Ubiquitin family | UBD|Alpha-Helix|UBA · all ubiquitin genes in this species |
| Ubiquitin family | UBD|Alpha-Helix|UBM · all ubiquitin genes in this species |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF06012 all species → | DUF908 | Domain of Unknown Function (DUF908) | Family | Interproscan |
| PF14377 all species → | UBM | Ubiquitin binding region | Motif | Interproscan |
| PF02825 all species → | WWE | WWE domain | Family | Interproscan |
| PF00627 all species → | UBA | UBA/TS-N domain | Domain | Interproscan |
| PF06025 all species → | DUF913 | Domain of Unknown Function (DUF913) | Family | Interproscan |
| PF00632 all species → | HECT | HECT-domain (ubiquitin-transferase) | Domain | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR035983 all species → | Homologous_superfamily | HECT, E3 ligase catalytic domain | Interproscan |
| IPR010309 all species → | Domain | E3 ubiquitin ligase, domain of unknown function DUF908 | Interproscan |
| IPR025527 all species → | Conserved_site | HUWE1/REV1, ubiquitin-binding motif | Interproscan |
| IPR004170 all species → | Domain | WWE domain | Interproscan |
| IPR015940 all species → | Domain | Ubiquitin-associated domain | Interproscan |
| IPR037197 all species → | Homologous_superfamily | WWE domain superfamily | Interproscan |
| IPR050409 all species → | Family | E3 ubiquitin-protein ligase | Interproscan |
| IPR016024 all species → | Homologous_superfamily | Armadillo-type fold | Interproscan |
| IPR010314 all species → | Domain | E3 ubiquitin ligase, domain of unknown function DUF913 | Interproscan |
| IPR009060 all species → | Homologous_superfamily | UBA-like superfamily | Interproscan |
| IPR000569 all species → | Domain | HECT domain | Interproscan |
| IPR018123 all species → | Domain | WWE domain, subgroup | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR11254 all species → | HECT DOMAIN UBIQUITIN-PROTEIN LIGASE | Interproscan |
| GO term | Category | Description | Source |
|---|---|---|---|
| GO:0004842 all species → | Molecular Function | ubiquitin-protein transferase activity | Interproscan |
| GO:0000139 all species → | Cellular Component | Golgi membrane | Interproscan |
| GO:0000209 all species → | Biological Process | protein polyubiquitination | Interproscan |
| GO:0005634 all species → | Cellular Component | nucleus | Interproscan |
| GO:0005737 all species → | Cellular Component | cytoplasm | Interproscan |
| GO:0007030 all species → | Biological Process | Golgi organization | Interproscan |
| GO:0016567 all species → | Biological Process | protein ubiquitination | Interproscan |
| GO:0061025 all species → | Biological Process | membrane fusion | Interproscan |
| GO:0061630 all species → | Molecular Function | ubiquitin protein ligase activity | Interproscan |
| GO:0005515 all species → | Molecular Function | protein binding | Interproscan |
| GO:0008270 all species → | Molecular Function | zinc ion binding | Interproscan |
| KO | Enzyme | Enzyme ID | Pathway | Map ID | Source |
|---|---|---|---|---|---|
| K10592 | HUWE1, MULE, ARF-BP1, TOM1; E3 ubiquitin-protein ligase HUWE1 | EC:2.3.2.26 | Ubiquitin system | ko04121 | deepkoala |
Genes whose expression across the transcriptome samples of Anthopleura xanthogrammica tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.
No co-expression network has been built for this species, so this gene has no partners to show. Networks are available for the species listed on the Network Analysis page.
Whether this gene can be visualised in the single-cell atlases of Anthopleura xanthogrammica, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.
No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.
Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.
No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.
Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.
| Analysis | What it does | Status | |
|---|---|---|---|
| Primer design | Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed. | template found | open → |
| BLAST | Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start. | template found | open → |
| Expression heatmap | Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it. | no expression matrix | – |
| Gene family / orthogroup | Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue. | open → | |
| Gene set analysis | Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it. | open → |