Detailed information of ENSOJPP00000018352.1 in Anthopleura xanthogrammica

Genomic Location: chr6:10223660...10264777
NR annotation: XP_031573677.1, E3 ubiquitin-protein ligase HUWE1-like isoform X1 [Actinia tenebrosa]
Species Anthopleura xanthogrammica · all data for this species · gene families


 Gene Structure
More details in JBrowse  Sequence
CDS
Transcript
Protein
 UniProt (Swiss-Prot top hit)
UniProt accessionDescription
Q7Z6Z7E3 ubiquitin-protein ligase HUWE1 OS=Homo sapiens OX=9606 GN=HUWE1 PE=1 SV=3
Q7TMY8E3 ubiquitin-protein ligase HUWE1 OS=Mus musculus OX=10090 GN=Huwe1 PE=1 SV=5
P51593E3 ubiquitin-protein ligase HUWE1 OS=Rattus norvegicus OX=10116 GN=Huwe1 PE=1 SV=3
 Gene family
Family typeMembership / link
Orthogroup (gene family)OG0002395 (this species only) · gene tree & orthology
Ubiquitin familyE3|E3 activity|HECT · all ubiquitin genes in this species
Ubiquitin familyUBD|Alpha-Helix|UBA · all ubiquitin genes in this species
Ubiquitin familyUBD|Alpha-Helix|UBM · all ubiquitin genes in this species

 Pfam domain
Pfam accessionPfam nameDescriptionTypeSource
PF06012
all species →
DUF908Domain of Unknown Function (DUF908)FamilyInterproscan
PF14377
all species →
UBMUbiquitin binding regionMotifInterproscan
PF02825
all species →
WWEWWE domainFamilyInterproscan
PF00627
all species →
UBAUBA/TS-N domainDomainInterproscan
PF06025
all species →
DUF913Domain of Unknown Function (DUF913)FamilyInterproscan
PF00632
all species →
HECTHECT-domain (ubiquitin-transferase)DomainInterproscan

 InterPro
InterPro termTypeDescriptionSource
IPR035983
all species →
Homologous_superfamilyHECT, E3 ligase catalytic domainInterproscan
IPR010309
all species →
DomainE3 ubiquitin ligase, domain of unknown function DUF908Interproscan
IPR025527
all species →
Conserved_siteHUWE1/REV1, ubiquitin-binding motifInterproscan
IPR004170
all species →
DomainWWE domainInterproscan
IPR015940
all species →
DomainUbiquitin-associated domainInterproscan
IPR037197
all species →
Homologous_superfamilyWWE domain superfamilyInterproscan
IPR050409
all species →
FamilyE3 ubiquitin-protein ligaseInterproscan
IPR016024
all species →
Homologous_superfamilyArmadillo-type foldInterproscan
IPR010314
all species →
DomainE3 ubiquitin ligase, domain of unknown function DUF913Interproscan
IPR009060
all species →
Homologous_superfamilyUBA-like superfamilyInterproscan
IPR000569
all species →
DomainHECT domainInterproscan
IPR018123
all species →
DomainWWE domain, subgroupInterproscan

 PANTHER
PANTHER termDescriptionSource
PTHR11254
all species →
HECT DOMAIN UBIQUITIN-PROTEIN LIGASEInterproscan

 Gene Ontology
GO termCategoryDescriptionSource
GO:0004842
all species →
Molecular Functionubiquitin-protein transferase activityInterproscan
GO:0000139
all species →
Cellular ComponentGolgi membraneInterproscan
GO:0000209
all species →
Biological Processprotein polyubiquitinationInterproscan
GO:0005634
all species →
Cellular ComponentnucleusInterproscan
GO:0005737
all species →
Cellular ComponentcytoplasmInterproscan
GO:0007030
all species →
Biological ProcessGolgi organizationInterproscan
GO:0016567
all species →
Biological Processprotein ubiquitinationInterproscan
GO:0061025
all species →
Biological Processmembrane fusionInterproscan
GO:0061630
all species →
Molecular Functionubiquitin protein ligase activityInterproscan
GO:0005515
all species →
Molecular Functionprotein bindingInterproscan
GO:0008270
all species →
Molecular Functionzinc ion bindingInterproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.
 KEGG pathway
KOEnzymeEnzyme IDPathwayMap IDSource
K10592HUWE1, MULE, ARF-BP1, TOM1; E3 ubiquitin-protein ligase HUWE1EC:2.3.2.26
Ubiquitin systemko04121deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Co-expression network

Genes whose expression across the transcriptome samples of Anthopleura xanthogrammica tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

No co-expression network has been built for this species, so this gene has no partners to show. Networks are available for the species listed on the Network Analysis page.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Anthopleura xanthogrammica, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

AnalysisWhat it doesStatus
Primer designDesign PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.template foundopen →
BLASTSearch this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.template foundopen →
Expression heatmapDraw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.no expression matrix
Gene family / orthogroupLook this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.open →
Gene set analysisStart a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.open →
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