Genomic Location: chr12:3800682...3802972
NR annotation: XP_031554633.1, methyl-CpG-binding domain protein 2-like [Actinia tenebrosa]
Species Anthopleura xanthogrammica · all data for this species · gene families
| CDS |
| ENSOJPT00000025741 |
| Transcript |
| ENSOJPT00000025741 |
| Protein |
| ENSOJPP00000022251.1 |
| UniProt accession | Description |
|---|---|
| Q9Z2E1 | Methyl-CpG-binding domain protein 2 OS=Mus musculus OX=10090 GN=Mbd2 PE=1 SV=2 |
| Q9UBB5 | Methyl-CpG-binding domain protein 2 OS=Homo sapiens OX=9606 GN=MBD2 PE=1 SV=1 |
| O95983 | Methyl-CpG-binding domain protein 3 OS=Homo sapiens OX=9606 GN=MBD3 PE=1 SV=1 |
| Family type | Membership / link |
|---|---|
| Orthogroup (gene family) | OG0007280 (this species only) · gene tree & orthology |
| Transcription factor family | MBD · all TF in this species |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF16564 all species → | MBDa | p55-binding region of Methyl-CpG-binding domain proteins MBD | Domain | Interproscan |
| PF14048 all species → | MBD_C | C-terminal domain of methyl-CpG binding protein 2 and 3 | Family | Interproscan |
| PF01429 all species → | MBD | Methyl-CpG binding domain | Domain | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR032343 all species → | Domain | Methyl-CpG-binding domain protein 2/3, p55-binding region | Interproscan |
| IPR025884 all species → | Domain | Methyl-CpG binding protein 2/3, C-terminal domain | Interproscan |
| IPR016177 all species → | Homologous_superfamily | DNA-binding domain superfamily | Interproscan |
| IPR001739 all species → | Domain | Methyl-CpG DNA binding | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR12396 all species → | METHYL-CPG BINDING PROTEIN, MBD | Interproscan |
| GO term | Category | Description | Source |
|---|---|---|---|
| GO:0003677 all species → | Molecular Function | DNA binding | Interproscan |
| GO:0000122 all species → | Biological Process | negative regulation of transcription by RNA polymerase II | Interproscan |
| GO:0005634 all species → | Cellular Component | nucleus | Interproscan |
| GO:0006346 all species → | Biological Process | DNA methylation-dependent constitutive heterochromatin formation | Interproscan |
| GO:0008327 all species → | Molecular Function | methyl-CpG binding | Interproscan |
| KO | Enzyme | Enzyme ID | Pathway | Map ID | Source |
|---|---|---|---|---|---|
| K11590 | MBD2; methyl-CpG-binding domain protein 2 | - | Chromosome and associated proteins | ko03036 | deepkoala |
Genes whose expression across the transcriptome samples of Anthopleura xanthogrammica tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.
No co-expression network has been built for this species, so this gene has no partners to show. Networks are available for the species listed on the Network Analysis page.
Whether this gene can be visualised in the single-cell atlases of Anthopleura xanthogrammica, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.
No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.
Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.
No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.
Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.
| Analysis | What it does | Status | |
|---|---|---|---|
| Primer design | Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed. | template found | open → |
| BLAST | Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start. | template found | open → |
| Expression heatmap | Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it. | no expression matrix | – |
| Gene family / orthogroup | Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue. | open → | |
| Gene set analysis | Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it. | open → |
