Gene detail

Detailed information of ENSOJPP00000022612.1 in Anthopleura xanthogrammica

Genomic Location: chr12:1411448...1441878
NR annotation: XP_031561537.1, ras GTPase-activating-like protein IQGAP1 isoform X3 [Actinia tenebrosa]
Species Anthopleura xanthogrammica · all data for this species · gene families

Gene Structure

More details in JBrowse

Sequence

CDS

ENSOJPT00000026132

ATGgagaataaaatagataagGAGGATGGACGGTGGGATCAAAACAGTGGAAGTTATGAAAGTGCAGGAGAAAGCGGACTCGAGAGAGCTTCAGGAACAGAGATGGATGAACAGAGAAAACAGAACCTGGCTTATCAATATTTGTGTCATCTAGAAGAAGCCAAAGTGTGGATGGAAGCTTGTCTTAAAGAAGACCTTCCTGAAACTACAGAACTTGAAGAAAGCATGAGAAATGGTGTTCACCTCGCGAAAGTCGGCAACTTCTTTGCTCCAAAAATTGTACCTCATCGTAGAATCTTCGACAAAGAGCTGAAACATTTTCTTTCCAAGGGGCTCCATTTTCGCCACACCGAcaatatcaattatttctttaaagcGTTAGAGGATGTTGGGCTTCCAAAGgtttttttcccagagACAACAGACATTTATGACAAAAAGAATATGCCAAAACTTATTTACTGCATTCATGCCTTGAGtttgttcCTCTTCAAGCTTGGTTTGGCTCCACAAATCcaagatttgtatggaaaagcTGAGTTCACAGaggAGCAGATTAGTGCTATGCGTAAAGAGCTTGAGAAATATGGTCTACAGCTGCCGGCATTCAGTAAAATAGGAGGAATCCTTGAAAGTGAGcTGCCAGTTGATGAGGCTGCATTGCATGCTGCTGTGATAGCTATCAATGAAGCTATTGATCACCAAGATGCCGCAGGTACCATGGAAGCCATGAAAAACCCCAATGCACATCTCGTAGACCTTGATTCCGAGAACACTGAGGCATATCAGAACCTGCTGTATGAAGCTAAAAATACCAAAGCCAAGCAGGCCCTTGCCAAGTCACCAGGAAGTGATAAAGAGGAAGATATCTATGACAAGTATCTGACTCAAGCAGAAATACAAGGAAATATCAATCAAGTGAATGAAACGATCAGGAAGAGGAAGGCTGAACAAGCTTTGAAGAAATCCGTCAACAATATTAACAACTTACTGGATGGTGAAGACCTTGAAGCATTGATAGCAGCTTTGTCAGACAAAGCTGCAGGATTAAAGAATGTTGACGGCCAAAATGGGCCGTGGTACCTAATGATGTTGAGGGAGAAGAGACAAGTAAAACAGGAGACCACTGGAGACCCAAATGCGCAGCTGACACAGAGTGAGATACAAGATGTTATCAATGGAGCTAATGAAGCTGGAGAAACACACCGCCAAATGCAAGTTACCGTATCTGCCATTAACAAGAGCCTTGATGGAGAAAATGCTGAAgaaactcacatgttgatacaAAAGCAAGAAGCTATGCTACCTAAAGTATTGGACAGAAGTGCATATCTCTACCATACTGAGCTAAAGAAGGCAAAGAACCAGAAACAAGCTGATCTGGAGCATATTGAATTAGAAGAGAAGGTCAAGGTTCTGACAGCTGCTGCAGCCATCAATGCAGCCATTGACAAGCAAAACCCAGATGAactgatgaaaaccatggagAGCCCTAATTCAGAGTTGTCATCAGTAGATGAGTCACTGGGTGGAAGTTACTTGGATCATTTTCAGTCGGTCAAACATGAAAAAGCACAGGACTGTGGAATCGGAAAGGATGACCTGACCCCATTCGAGCTGCAAATTTGCGTGGATTACGTCAACTCTGTCGTACAAGAGGAACATGATCTGATCGCCGCGTTATCGGTAATTAATGTGAACATCGATAAAGGAGACGCAGACGAAACCACACGATCTTTACAAGTGGATGCTGCTAAGCTGTCAGGAGTGGACGCTGCTAATGCAGAGCTGTACCAAGATGTACTGTTTGCCAGTAAAAGATCCAAAGCACAGAAAACCAATGACAGATCCGCAGAGCTTTGGCATGATGAGATCCAACCATGTATCGACCACTCTAACAAACATGCCGATGACACCAATCAGCTAGCGCAGGGACTAGTAGCTATTAACCAGATTATTGACCGTGGTGATGCTCAATCCTTTGGTAATGCCCTGAGTGACCCTGCTGTTGGAATACGAGGTGTCACACAAGAATGTACAGAGAAATATTTACAGGCGCTGAAGGAAGCTaaacagaagaagaaagagaatgGAGGAACATCGCCGTGGTTAGAGCAGAAAACCAGTTATGGTCATGTCTACTACTATAACAACGAGACAGGAGAGACAAGCTGGACGAAACCTGCTGACTTTAAGGACAATTCTTCACTTCTCTCAAAAGAGGATATTCAGAGCGTGGTATCGCGTGAGACAGGAGAACATGACCGTATGGTATACCTTACCTCAAACGAACCAACCATCATCAAACTACAGTCTCACTTTAAGGGCTACTTGGCGCGCAAGTCATATAAGAATAGAATGACCTTCATCAAAGAACAACTACCAGCTATCATAAAGATACAGTCAAATGTCAGAGGATTCCTACAGCGAATCAGGTATCGTAGAAGATTAAAAGAACTTAAATCATCAGAACAAGATGTCATCAAGatccAGTCGCATGTCAGAATGTTTCTTGCAAGAAAGCAATAcagaggaaggaagaaatacTTCGATGAGCACCAAAATGCCATCATCAAGATCCAGGCCTGGGTGAGAGCAAATGTGATTACCGGTAATATTGcgcacaatgttgcaccgtgtgtccataAATTACAAAAACTTCGCGCACAAGTTGTGACGGACATCAGATCAAACCAACAATTGGAGAACGATCTGAACCTAATGGATATCAAGATAGGATTATTAGTAAAGAACAGGATTACGCTACAGgATGTGGTTCATCACGGAAAGAAGCTCAAGAGAGAAAAACAAGACATGATGTCAGCAGTACAGAGAACTAAAGGAATCAAGTCTCTGAGTAAGGAAAGCAGAGAGAAACTAGAAGCATATCAGAATCTTTTCTACTTACTACAGACAAATCCTACATACCTAGCCAAGCTGATCTTTGAAATGCCCCAGAGTAAAACCACCAAATTCATGGAGTCTGTGGTCCTCACCTTGTATAACTACGCGTCAAACACCAGAGAAGAATATCTGTTACTTAAGCTATTCGAGACTTTATTTTCCCGATATTCTAAAATAGATCAACCGGTTGAGATCatcacaggaaacccaacggTTATCAGGATGGTAGTTCATTTTAACAGAGGTCAAAGGGGTCAGAGCTCACTAAGAGATCTACTGGAGCCATTGGTAAATGACATCCTGAAAgacaaaaatatcaacatcaaTACCAATCCACTGGATGTTTATAAAGCATGGGTCAATCAAATGGAGTCTGTGACTGGAGAAACCAGtAAATTACCATACGATGTGGACCCAGAACAAGCCTTGAAGCACCCCGAAGTGGTAGAAAGAATCGACGCCTCCGTAAAGTCACTTATCGCAGCCACAGACAAGTTCCTTAACTCCATTATTCAATCAGTGGATAAAATACCTTATGGGTTACGGTACGTAGCAATGACGCTACGAATATCATTAACAGAAAAGTTCCCCAACGTACCAGAAGAGGAGATCTTCAAGGTTGTCGGTAATCTCATTTACTATCGTTACATGAACCCTGCAATTGTCGCACCAGATGCCTTTGATATTGTGAACCTAAGTGTCGAGAAAGGCCTTTTATCAGAACAGagacGTAATCTTGGTATTATCGCAAAGCTTCTTCAGTTTGCTGCTTCCAACAAACTCTATGATGGAGCGAATTCTCATCTCGGTGAACTGAACAAGTACATCAAAGAAGCTAATCAAAAGTTTAAAAAATACTTCCTTGAAGTATCAACGGTGGAAGAGCCTGAATCGCGCTTCAACATCGATGAATACACAGACGTGGTCATGTTAACCAAACCGGTCATCTACATCTCTGTACAAGAAATCTGTGACACACATATACTTCTTCTGGAACATCAAGAGCAGATAGCACTAGATGTTAACGACCCTTTACATGAACTGTTAGATGACTTGGGTGACGCCCCTAATGTAAaggatctgattgGAGGTAACCCCGAAGACGTAGACCACGACCAGGAAGTAGCCAATGTGGCCAAAACAGAGATCTCCCTCATGTTGACCAATAAATTCGAGGtccctgatgatgatgattctgaTATGAGGGCTCTCTTTGTCAGaaCAAAACGTTTGATAGTCGATTTGCTGATGGTACAACAAGGAGAAAACCTGACGGAAATACTAGAAACAACGGCTACAGAAGAACAGGAAGCCGCACACACGAATCTTAtgaaggaaagagaaaagaacgaagaaagaaaacgaaaaaatactCAAGTCAGGCGATCTGCTTCCATATATGGAGATAACAAACTTCCATTAGAAGGTCTTAAACGAAAGATTATACGAAACTTACGAATGCTTGAAAGCCAGGGACTTGTGACGATCAAGAATGACTACCAGGATATCGTGAATGCCATCGCCAAGgATATTAGAAATCAAAGAAGATACAGACAAAGAAGACgacaagaaagaagaaagctaAAACAAACCCTCGACAGTCTGCAGACAAAAACCCACTTCTACGAGGAACAAATCGATTATTACAACCAGTATATCCGCGTGTGTCTTGATAACCTCTCCAAGAAGGGCAAGAAACCATCCCGAAGCATCAAACAAGGCAAGAAGGCTAAAGAAGAAGTCTACAAGGGAGAACTGAAGTACAGTGCCCAAAGATTGTACGAGAAAGGCGTGATTCTGGAAATCGAGGGGCTACCACCCGCGCAGTTTAAGAATGTCATGTTCGAAATCAAGTCAGGAGATGATGTGGGTTCATTTGCGGTGTCAGCCAAATTCATGGGCGTTGCCATGGAAAAAGTCGAACTGGTTTTCCAGGATCTTCTTCAGCTCCAATACGAGGGTGTGGCCGTCATGAAGATGTTCGGAAGAGCGAAAATCAATGTGAATCTTCTTATTTTCCTCTTGAACAAGAAGTTCTACGGCAAATAA

Transcript

ENSOJPT00000026132

Protein

UniProt (Swiss-Prot top hit)

UniProt accession	Description
P46940	Ras GTPase-activating-like protein IQGAP1 OS=Homo sapiens OX=9606 GN=IQGAP1 PE=1 SV=1
Q9JKF1	Ras GTPase-activating-like protein IQGAP1 OS=Mus musculus OX=10090 GN=Iqgap1 PE=1 SV=2
Q86VI3	Ras GTPase-activating-like protein IQGAP3 OS=Homo sapiens OX=9606 GN=IQGAP3 PE=1 SV=2

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0002232 (this species only) · gene tree & orthology

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF00612 all species →	IQ	IQ calmodulin-binding motif	Motif	Interproscan
PF00616 all species →	RasGAP	GTPase-activator protein for Ras-like GTPase	Family	Interproscan
PF00307 all species →	CH	Calponin homology (CH) domain	Domain	Interproscan
PF03836 all species →	RasGAP_C	RasGAP C-terminus	Family	Interproscan
PF00397 all species →	WW	WW domain	Domain	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR001202 all species →	Domain	WW domain	Interproscan
IPR000048 all species →	Binding_site	IQ motif, EF-hand binding site	Interproscan
IPR036872 all species →	Homologous_superfamily	CH domain superfamily	Interproscan
IPR008936 all species →	Homologous_superfamily	Rho GTPase activation protein	Interproscan
IPR001936 all species →	Domain	Ras GTPase-activating domain	Interproscan
IPR001715 all species →	Domain	Calponin homology domain	Interproscan
IPR036020 all species →	Homologous_superfamily	WW domain superfamily	Interproscan
IPR000593 all species →	Domain	RasGAP protein, C-terminal	Interproscan
IPR023152 all species →	Conserved_site	Ras GTPase-activating protein, conserved site	Interproscan
IPR027417 all species →	Homologous_superfamily	P-loop containing nucleoside triphosphate hydrolase	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR14149 all species →	RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0005515 all species →	Molecular Function	protein binding	Interproscan
GO:0043087 all species →	Biological Process	regulation of GTPase activity	Interproscan
GO:0005096 all species →	Molecular Function	GTPase activator activity	Interproscan
GO:0005516 all species →	Molecular Function	calmodulin binding	Interproscan
GO:0005938 all species →	Cellular Component	cell cortex	Interproscan
GO:0051015 all species →	Molecular Function	actin filament binding	Interproscan
GO:1903479 all species →	Biological Process	mitotic actomyosin contractile ring assembly actin filament organization	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

KO	Enzyme	Enzyme ID	Pathway	Map ID	Source
K16848	IQGAP1; Ras GTPase-activating-like protein IQGAP1	-	Exosome	ko04147	deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Co-expression network

Genes whose expression across the transcriptome samples of Anthopleura xanthogrammica tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

No co-expression network has been built for this species, so this gene has no partners to show. Networks are available for the species listed on the Network Analysis page.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Anthopleura xanthogrammica, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

Analysis	What it does	Status
Primer design	Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.	template found	open →
BLAST	Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.	template found	open →
Expression heatmap	Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.	no expression matrix	–
Gene family / orthogroup	Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.		open →
Gene set analysis	Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.		open →