Genomic Location: :...
NR annotation: PFX16383.1, E3 ubiquitin-protein ligase HUWE1 [Stylophora pistillata]
| CDS | ||||
| ENSPTBT00000014566 | ||||
| Transcript |
| ENSPTBT00000014566 |
| Protein |
| ENSPTBP00000013854.1 |
| Uniprot term | Description | |||
|---|---|---|---|---|
| Q7Z6Z7 | E3 ubiquitin-protein ligase HUWE1 OS=Homo sapiens OX=9606 GN=HUWE1 PE=1 SV=3 | |||
| Q7TMY8 | E3 ubiquitin-protein ligase HUWE1 OS=Mus musculus OX=10090 GN=Huwe1 PE=1 SV=5 | |||
| P51593 | E3 ubiquitin-protein ligase HUWE1 OS=Rattus norvegicus OX=10116 GN=Huwe1 PE=1 SV=3 |
| Gene family | Subfamily |
|---|---|
| Ubiquitin Family | E3|E3 activity|HECT |
| Ubiquitin Family | UBD|Alpha-Helix|UBM |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF00627 | UBA | UBA/TS-N domain | Domain | Interproscan |
| PF17855 | MCM_lid | MCM AAA-lid domain | Domain | Interproscan |
| PF06025 | DUF913 | Domain of Unknown Function (DUF913) | Family | Interproscan |
| PF06012 | DUF908 | Domain of Unknown Function (DUF908) | Family | Interproscan |
| PF00632 | HECT | HECT-domain (ubiquitin-transferase) | Domain | Interproscan |
| PF02825 | WWE | WWE domain | Family | Interproscan |
| PF00493 | MCM | MCM P-loop domain | Domain | Interproscan |
| PF17207 | MCM_OB | MCM OB domain | Domain | Interproscan |
| PF14377 | UBM | Ubiquitin binding region | Motif | Interproscan |
| PF12619 | MCM2_N | Mini-chromosome maintenance protein 2 | Family | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR000569 | Domain | HECT domain | Interproscan |
| IPR031327 | Family | Mini-chromosome maintenance protein | Interproscan |
| IPR001208 | Domain | MCM domain | Interproscan |
| IPR015940 | Domain | Ubiquitin-associated domain | Interproscan |
| IPR037197 | Homologous_superfamily | WWE domain superfamily | Interproscan |
| IPR027417 | Homologous_superfamily | P-loop containing nucleoside triphosphate hydrolase | Interproscan |
| IPR018525 | Conserved_site | Mini-chromosome maintenance, conserved site | Interproscan |
| IPR041562 | Domain | MCM, AAA-lid domain | Interproscan |
| IPR008045 | Family | DNA replication licensing factor Mcm2 | Interproscan |
| IPR010314 | Domain | E3 ubiquitin ligase, domain of unknown function DUF913 | Interproscan |
| IPR010309 | Domain | E3 ubiquitin ligase, domain of unknown function DUF908 | Interproscan |
| IPR041918 | Domain | HUWE1, UBA domain | Interproscan |
| IPR016024 | Homologous_superfamily | Armadillo-type fold | Interproscan |
| IPR009060 | Homologous_superfamily | UBA-like superfamily | Interproscan |
| IPR012340 | Homologous_superfamily | Nucleic acid-binding, OB-fold | Interproscan |
| IPR004170 | Domain | WWE domain | Interproscan |
| IPR035983 | Homologous_superfamily | HECT, E3 ligase catalytic domain | Interproscan |
| IPR033762 | Domain | MCM OB domain | Interproscan |
| IPR025527 | Conserved_site | HUWE1/REV1, ubiquitin-binding motif | Interproscan |
| IPR050409 | Family | E3 ubiquitin-protein ligase | Interproscan |
| IPR018123 | Domain | WWE domain, subgroup | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR11254 | HECT DOMAIN UBIQUITIN-PROTEIN LIGASE | Interproscan |
| GO terms | Category | Description | Source |
|---|---|---|---|
| GO:0004842 | Molecular Function | ubiquitin-protein transferase activity | Interproscan |
| GO:0003677 | Molecular Function | DNA binding | Interproscan |
| GO:0005524 | Molecular Function | ATP binding | Interproscan |
| GO:0032508 | Biological Process | DNA duplex unwinding | Interproscan |
| GO:0006260 | Biological Process | DNA replication | Interproscan |
| GO:0005634 | Cellular Component | nucleus | Interproscan |
| GO:0006270 | Biological Process | DNA replication initiation | Interproscan |
| GO:0042555 | Cellular Component | MCM complex | Interproscan |
| GO:1905775 | Biological Process | obsolete negative regulation of DNA helicase activity | Interproscan |
| GO:0005515 | Molecular Function | protein binding | Interproscan |
| GO:0000209 | Biological Process | protein polyubiquitination | Interproscan |
| GO:0005737 | Cellular Component | cytoplasm | Interproscan |
| GO:0016567 | Biological Process | protein ubiquitination | Interproscan |
| GO:0061630 | Molecular Function | ubiquitin protein ligase activity | Interproscan |
| GO:0008270 | Molecular Function | zinc ion binding | Interproscan |